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产品概述
| 名称 | AML12 (小鼠正常肝细胞) (STR鉴定正确) |
| 别称 | AML-12; AML 12; Alpha Mouse Liver 12 |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | The AML12 (alpha mouse liver 12) cell line was established from hepatocytes from a mouse (CD1 strain, line MT42) transgenic for human TGF alpha. |
| 年龄（性别） | 雄性；3月龄 |
| 组织来源 | 肝脏 |
| 细胞类型 | 自发永生化细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~37 hours |
| 致瘤性 | NO |
| 基因表达情况 | albumin; human transforming growth factor alpha (TGF alpha); mouse TGF alpha. |
| 保藏机构 | ATCC; CRL-2254 BCRC; 60326 BCRJ; 0354 |
STR鉴定
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STR位点信息
18-3 21 6-7 12 5-5 14,15 X-1 26 1-2 13 7-1 29 8-1 14,15 1-1 11 19-2 13 15-3 21.3 12-1 19 6-4 16 4-2 20.3 3-2 12 2-1 9 13-1 15.1,15.2
11-2 18,19 17-2 13,14,15 -
STR鉴定图
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参考文献
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A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy (2024-01-09)
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2024.121795
影响因子 ：11.2
引用产品： 4T1 细胞 , HL-1 细胞 , 大鼠小肠隐窝上皮细胞 , AML12 细胞 , MDA-MB-231/GFP 细胞
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Inhibition of PTPRE suppresses tumor progression and improves sorafenib response in hepatocellular carcinoma (2024-03-08)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2024.116366
影响因子 ：7.5
引用产品： THLE-3 细胞 , AML12 细胞
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Human umbilical cord-derived mesenchymal stem cells ameliorate liver fibrosis by improving mitochondrial function via Slc25a47-Sirt3 signaling pathway (2024-01-09)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2024.116133
影响因子 ：7.5
引用产品： AML12 细胞
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Dendrobium officinale regulate lipid metabolism in diabetic mouse liver via PPAR-RXR signaling pathway: Evidence from an integrated multi-omics analysis (2024-03-08)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2024.116395
影响因子 ：7.5
引用产品： AML12 细胞
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FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease (2024-01-06)
期刊：Hepatology International
DOI：10.1007/s12072-023-10621-x
影响因子 ：6.6
引用产品： AML12 细胞
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Identification of potential pathogenic hepatic super-enhancers regulatory network in high-fat diet induced hyperlipidemia (2024-01-17)
期刊：JOURNAL OF NUTRITIONAL BIOCHEMISTRY
DOI：10.1016/j.jnutbio.2024.109584
影响因子 ：5.6
引用产品： AML12 细胞 , AML-12细胞专用培养基
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Identification and validation of cuproptosis-related molecular clusters in non-alcoholic fatty liver disease (2024-01-03)
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：5.3
引用产品： AML12 细胞
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METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen–Glucose Deprivation/Reperfusion Injury (2024-01-18)
期刊：INFLAMMATION
DOI：10.1007/s10753-023-01958-4
影响因子 ：5.1
引用产品： AML12 细胞 , DMEM/F12 培养基
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Exploring the mechanism and phytochemicals in Psoraleae Fructus-induced hepatotoxicity based on RNA-seq, in vitro screening and molecular docking (2024-01-19)
期刊：Scientific Reports
DOI：10.1038/s41598-023-50454-0
影响因子 ：4.6
引用产品： AML12 细胞
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BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease (2024-01-11)
期刊：INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
DOI：10.1016/j.biocel.2024.106517
影响因子 ：4.0
引用产品： AML12 细胞
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The augment effects of magnesium hydride on the lipid lowering effect of atorvastatin: an in vivo and in vitro investigation (2024-03-28)
期刊：Medical Gas Research
DOI：10.4103/mgr.MEDGASRES-D-23-00047
影响因子 ：2.9
引用产品： AML12 细胞
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Ganoderic acid A attenuated hepatic impairment by down-regulating the intracellular JAK2-STAT3 signaling pathway in induced mushroom poisoning (2024-01-15)
期刊：American Journal of Translational Research
DOI：PMID:38322557
影响因子 ：2.2
引用产品： AML12 细胞
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tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis (2023-04-03)
期刊：Signal Transduction and Targeted Therapy
DOI：10.1038/s41392-023-01351-5
影响因子 ：39.3
引用产品： HL-7702 [L-02; LO2] 细胞 , AML12 细胞
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m6A modification-tuned sphingolipid metabolism regulates postnatal liver development in male mice (2023-05-15)
期刊：Nature Metabolism
DOI：10.1038/s42255-023-00808-9
影响因子 ：20.8
引用产品： AML12 细胞
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Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2 (2023-08-01)
期刊：Nature Communications
DOI：10.1038/s41467-023-40327-5
影响因子 ：16.6
引用产品： AML12 细胞 , Hep G2 细胞 , AML-12细胞专用培养基
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O-GlcNAcylation of Raptor transduces glucose signals to mTORC1 (2023-08-03)
期刊：MOLECULAR CELL
DOI：10.1016/j.molcel.2023.07.011
影响因子 ：16.0
引用产品： AML-12细胞专用培养基 , AML12 细胞
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Inhibition of free heme-catalyzed Fenton-like reaction prevents non-alcoholic fatty liver disease by hepatocyte-targeted hydrogen delivery (2023-07-01)
期刊：BIOMATERIALS
DOI：10.1016/j.biomaterials.2023.122230
影响因子 ：14.0
引用产品： AML12 细胞
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DBF4 Dependent Kinase Inhibition Suppresses Hepatocellular Carcinoma Progression and Potentiates Anti-Programmed Cell Death-1 Therapy (2023-07-03)
期刊：International Journal of Biological Sciences
影响因子 ：9.2
引用产品： AML12 细胞
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Human menstrual blood-derived stem cells alleviate autoimmune hepatitis via JNK/MAPK signaling pathway in vivo and in vitro (2023-04-03)
期刊：Frontiers of Medicine
影响因子 ：8.1
引用产品： AML12 细胞
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Surface Engineering of HEK293 Cell-Derived Extracellular Vesicles for Improved Pharmacokinetic Profile and Targeted Delivery of IL-12 for the Treatment of Hepatocellular Carcinoma (2023-01-12)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
引用产品： AML12 细胞 , MRC-5 细胞 , 293T [HEK-293T] 细胞 , RAW 264.7 细胞 , Hep G2 细胞
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Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1 (2023-01-07)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-022-03862-1
影响因子 ：7.4
引用产品： AML12 细胞 , McCoy's 5A 培养基
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ETNPPL impairs autophagy through regulation of the ARG2-ROS signaling axis, contributing to palmitic acid-induced hepatic insulin resistance (2023-02-24)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2023.02.017
影响因子 ：7.4
引用产品： Hep G2 细胞 , AML12 细胞 , 293T [HEK-293T] 细胞 , 293A 细胞
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Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen-related receptor α expression in liver (2023-08-10)
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.7982
影响因子 ：7.2
引用产品： AML12 细胞
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Sappanone A Alleviates the Severity of Carbon Tetrachloride-Induced Liver Fibrosis in Mice (2023-09-04)
期刊：Antioxidants
影响因子 ：7.0
引用产品： AML12 细胞 , RAW 264.7 细胞 , LX-2 细胞
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Adipose-Derived Mesenchymal Stem Cells Inhibit JNK-Mediated Mitochondrial Retrograde Pathway to Alleviate Acetaminophen-Induced Liver Injury (2023-01-09)
期刊：Antioxidants
影响因子 ：7.0
引用产品： AML12 细胞
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Environmental toxin chlorpyrifos induces liver injury by activating P53-mediated ferroptosis via GSDMD-mtROS (2023-04-24)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.114938
影响因子 ：6.8
引用产品： AML12 细胞
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Perfluorooctane sulfonate (PFOS), a novel environmental pollutant, induces liver injury in mice by activating hepatocyte ferroptosis (2023-10-27)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115625
影响因子 ：6.8
引用产品： AML12 细胞 , AML-12细胞专用培养基
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Cannabidiol alleviates perfluorooctane sulfonate-induced macrophage extracellular trap mediate inflammation and fibrosis in mice liver (2023-08-15)
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115374
影响因子 ：6.8
引用产品： RAW 264.7 细胞 , AML12 细胞 , LX-2 细胞
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Farnesoid X receptor overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in nonalcoholic fatty liver disease (2023-10-31)
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2023.166930
影响因子 ：6.2
引用产品： AML12 细胞 , 特级胎牛血清 , 胰岛素-转铁蛋白-硒添加剂 (ITS-G)，100×
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Identification of antioxidant peptides after digestion and absorption of isinglass by serum peptidomics and cellular antioxidant activity analysis (2023-02-10)
期刊：Food & Function
影响因子 ：6.1
引用产品： AML12 细胞 , DMEM/F12 培养基
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Self-assembled FGF21 nanoparticles alleviate drug-induced acute liver injury (2023-01-10)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2022.1084799
影响因子 ：5.6
引用产品： AML12 细胞
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Trans-anethole pretreatment ameliorates hepatic ischemia–reperfusion injury via regulation of soluble epoxide hydrolase (2023-09-08)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110809
影响因子 ：5.6
引用产品： AML12 细胞 , AML-12细胞专用培养基
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Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells and promote liver fibrosis via the MAPK/STMN1 axis activation (2023-01-04)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109605
影响因子 ：5.6
引用产品： AML12 细胞 , 青霉素-链霉素溶液 (双抗)，100× , DMEM/F12 培养基 , 小鼠肝星状细胞 , 小鼠肝星状细胞完全培养基
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Use of a ferroptosis-related gene signature to construct diagnostic and prognostic models for assessing immune infiltration in metabolic dysfunction-associated fatty liver disease (2023-10-19)
期刊：Frontiers in Cell and Developmental Biology
DOI：10.3389/fcell.2023.1199846
影响因子 ：5.5
引用产品： AML12 细胞 , DMEM高糖 培养基
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Water extract of earthworms mitigates mouse liver fibrosis by potentiating hepatic LKB1/Nrf2 axis to inhibit HSC activation and hepatocyte death (2023-11-26)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
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Adelmidrol ameliorates liver ischemia-reperfusion injury through activating Nrf2 signaling pathway (2023-12-17)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.176224
影响因子 ：5.0
引用产品： AML12 细胞 , DMEM/F12 培养基
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Heme oxygenase 1 alleviates nonalcoholic steatohepatitis by suppressing hepatic ferroptosis (2023-07-08)
期刊：Lipids in Health and Disease
DOI：10.1186/s12944-023-01855-7
影响因子 ：4.5
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Suppression of SIRT1/FXR signaling pathway contributes to oleanolic acid-induced liver injury (2023-04-05)
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116509
影响因子 ：3.8
引用产品： AML12 细胞
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Low‑dose ionizing radiation attenuates high glucose‑induced hepatic apoptosis and immune factor release via modulation of a miR‑155‑SOCS1 axis (2023-07-24)
期刊：Molecular Medicine Reports
影响因子 ：3.4
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AMP-activated protein kinase-farnesoid X receptor pathway contributes to oleanolic acid-induced liver injury (2023-02-27)
期刊：JOURNAL OF APPLIED TOXICOLOGY
DOI：10.1002/jat.4456
影响因子 ：3.3
引用产品： AML12 细胞
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In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS (2023-03-13)
期刊：XENOBIOTICA
DOI：10.1080/00498254.2023.2188070
影响因子 ：1.8
引用产品： AML12 细胞
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Multicomponent microspheres with spatiotemporal drug release for post-surgical liver cancer treatment and liver regeneration (2022-12-01)
期刊：CHEMICAL ENGINEERING JOURNAL
影响因子 ：16.7
引用产品： AML12 细胞
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Dietary Lactobacillus reuteri prevent from inflammation mediated apoptosis of liver via improving intestinal microbiota and bile acid metabolism (2022-10-18)
期刊：FOOD CHEMISTRY
DOI：10.1016/j.foodchem.2022.134643
影响因子 ：9.2
引用产品： AML12 细胞
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Inhibition of HSPA8 by rifampicin contributes to ferroptosis via enhancing autophagy (2022-10-18)
期刊：LIVER INTERNATIONAL
影响因子 ：8.8
引用产品： AML12 细胞 , AML-12细胞专用培养基
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FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease (2022-11-03)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2022.10.322
影响因子 ：8.1
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Exosomes derived from human umbilical cord mesenchymal stem cells ameliorate experimental non-alcoholic steatohepatitis via Nrf2/NQO-1 pathway (2022-09-10)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2022.08.037
影响因子 ：8.1
引用产品： DMEM/F12 培养基 , Hep G2 细胞 , AML12 细胞
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ADSCs-derived exosomes ameliorate hepatic fibrosis by suppressing stellate cell activation and remodeling hepatocellular glutamine synthetase-mediated glutamine and ammonia homeostasis (2022-10-04)
期刊：Stem Cell Research & Therapy
DOI：10.1186/s13287-022-03049-x
影响因子 ：8.1
引用产品： AML12 细胞 , 小鼠肝星状细胞 , 小鼠肝星状细胞完全培养基
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A new cell-free therapeutic strategy for liver regeneration: Human placental mesenchymal stem cell-derived extracellular vesicles (2022-10-20)
期刊：Journal of Tissue Engineering
影响因子 ：7.9
引用产品： AML12 细胞 , HL-7702 [L-02; LO2] 细胞
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Targeting PARK7 Improves Acetaminophen-Induced Acute Liver Injury by Orchestrating Mitochondrial Quality Control and Metabolic Reprogramming (2022-10-28)
期刊：Antioxidants
影响因子 ：7.7
引用产品： AML12 细胞
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The Protective Effect of Sericin on AML12 Cells Exposed to Oxidative Stress Damage in a High-Glucose Environment (2004-02-20)
期刊：Antioxidants
影响因子 ：7.0
引用产品： AML12 细胞
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Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD Induced by Obesity by Regulating the KEAP1/NRF2 Pathway (2002-02-20)
期刊：Antioxidants
影响因子 ：7.0
引用产品： AML12 细胞
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Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles (2022-12-12)
期刊：Journal of Cell Communication and Signaling
DOI：10.1007/s12079-022-00716-9
影响因子 ：5.9
引用产品： AML12 细胞
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Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress (2022-10-17)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2022.109185
影响因子 ：5.7
引用产品： AML12 细胞 , DMEM/F12 培养基
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Liraglutide inhibits receptor for advanced glycation end products (RAGE)/reduced form of nicotinamide-adenine dinucleotide phosphate (NAPDH) signaling to ameliorate non-alcoholic fatty liver disease (NAFLD) in vivo and vitro (2002-02-20)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2036902
影响因子 ：4.9
引用产品： AML12 细胞
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SIRT5 alleviates hepatic ischemia and reperfusion injury by diminishing oxidative stress and inflammation via elevating SOD1 and IDH2 expression (2022-08-19)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2022.113319
影响因子 ：4.1
引用产品： AML12 细胞 , AML-12细胞专用培养基
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Octreotide ameliorates hepatic ischemia-reperfusion injury through SNHG12/TAF15-mediated Sirt1 stabilization and YAP1 transcription (2003-02-20)
期刊：Toxicology And Applied Pharmacology
DOI：10.1016/j.taap.2022.115975
影响因子 ：3.8
引用产品： AML12 细胞
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Circadian rhythm disorders elevate macrophages cytokines release and promote multiple tissues/organs dysfunction in mice (2003-02-20)
期刊：Physiol Behav
DOI：10.1016/j.physbeh.2022.113772
影响因子 ：2.9
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Basic fibroblast growth factor protects against liver ischemia-reperfusion injury via the Nrf2/Hippo signaling pathway (2022-09-08)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2022.101921
影响因子 ：2.6
引用产品： AML12 细胞
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Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast (2011-01-20)
期刊：Pharmacological Research
DOI：10.1016/j.phrs.2021.106004
影响因子 ：10.3
引用产品： AML12 细胞 , AML-12细胞专用培养基
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