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产品概述
| 名称 | SK-Hep-1 (人肝窦内皮细胞) (STR鉴定正确) |
| 别称 | SK-Hep-1; SK HEP-1; SK HEP 01; SK-Hep1; Sk-Hep1; SK Hep1; SKHEP-1; SKHEP1; SKHep1; SK_HEP1 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | SK-HEP-1细胞已被鉴定为内皮来源，最新研究表明该细胞系为肝窦内皮细胞。SK-HEP-1细胞来源于52岁男性，染色体在亚三倍体范围内。在裸鼠中，SK-HEP-1细胞能形成与肝癌相一致的大细胞癌。 |
| 年龄（性别） | 男性；52岁 |
| 组织来源 | 肝，腹水 |
| 细胞类型 | 自发永生化细胞系 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~30 hours |
| 致瘤性 | Yes, in nude mice; forms large cell carcinoma consistent with hepatoma. |
| 保藏机构 | ATCC; HTB-52 DSMZ; ACC-141 ECACC; 91091816 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 20,23 D3S1358 16 D5S818 10,13 D7S820 8,11 D8S1179 13,14 D13S317 8,12 D16S539 12 D18S51 13,15 D19S433 12,15.2 D21S11 29,31 FGA 17 PentaD 13,14 PentaE 21 TH01 7,9 TPOX 9 vWA 14,17 D6S1043 11 D12S391 18,19 D2S441 12.3,14 -
STR鉴定图
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参考文献
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Advanced Nanoencapsulation-Enabled Ultrasensitive Analysis: Unraveling Tumor Extracellular Vesicle Subpopulations for Differential Diagnosis of Hepatocellular Carcinoma via DNA Cascade Reactions (2024-04-17)
期刊：ACS Nano
影响因子 ：15.8
引用产品： Hep G2 细胞 , SK-Hep-1 细胞 , HuH-7 细胞 , HL-7702 [L-02; LO2] 细胞 , Hela 细胞 , MCF7 [MCF-7] 细胞 , A-375 细胞
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Harnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subtyping (2024-07-12)
期刊：Nature Communications
DOI：10.1038/s41467-024-50064-y
影响因子 ：14.7
引用产品： Ramos [RA 1] 细胞 , MDA-MB-231 细胞 , MCF 10A 细胞 , SK-Hep-1 细胞
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BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma (2024-02-10)
期刊：CELLULAR AND MOLECULAR LIFE SCIENCES
DOI：10.1007/s00018-024-05144-z
影响因子 ：8.0
引用产品： Hep G2 细胞 , SK-Hep-1 细胞
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Constructing a disulfidptosis-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing and weighted co-expression network analysis (2024-05-17)
期刊：APOPTOSIS
DOI：10.1007/s10495-024-01968-z
影响因子 ：7.2
引用产品： Hep G2 细胞 , HuH-7 细胞 , MHCC97-L 细胞 , HCCLM3 细胞 , SK-Hep-1 细胞
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A triggered DNA nanomachine with enzyme-free for the rapid detection of telomerase activity in a one-step method (2024-02-27)
期刊：ANALYTICA CHIMICA ACTA
影响因子 ：6.2
引用产品： Hela 细胞 , SK-Hep-1 细胞 , HuH-7 细胞
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TRIM21 is critical in regulating hepatocellular carcinoma growth and response to therapy by altering the MST1/YAP pathway (2024-03-12)
期刊：CANCER SCIENCE
影响因子 ：5.7
引用产品： HuH-7 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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Polyphyllin I exerts anti-hepatocellular carcinoma activity by targeting ZBTB16 to activate the PPARγ/RXRα signaling pathway (2024-08-24)
期刊：Chinese Medicine
DOI：10.1186/s13020-024-00984-0
影响因子 ：5.3
引用产品： SK-Hep-1 细胞 , Hep 3B2.1-7细胞专用培养基 , SK-Hep-1细胞专用培养基 , Hep 3B2.1-7 细胞
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Multimodal Theranostic Nanoparticles for Necrosis Targeting, Fluorescence/SPECT Imaging, and Radiotherapy of Residual Tumors after Hepatocellular Carcinoma Ablation (2024-03-07)
期刊：MOLECULAR PHARMACEUTICS
DOI：10.1021/acs.molpharmaceut.3c01081
影响因子 ：4.9
引用产品： SK-Hep-1 细胞
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The P53-P21-RB1 pathway promotes BRD4 degradation in liver cancer through USP1 (2024-02-01)
期刊：JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 ：4.8
引用产品： SK-Hep-1 细胞 , MEM (含NEAA) 培养基
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Unlocking the Potential of Traditional Chinese Medicine (TCM): Shipi Xiaoji Formula (SPXJF) as a Novel Ferroptosis Inducer in Hepatocellular Carcinoma (2024-12-12)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：4.8
引用产品： MEM（含NEAA） 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液（双抗），100× , SK-Hep-1 细胞
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UBA2 SUMOylates NQO1 and promotes the proliferation of hepatocellular carcinoma by modulating the MAPK pathway (2024-07-16)
期刊：CANCER SCIENCE
影响因子 ：4.5
引用产品： SNU-368 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞
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KLF7 Promotes Hepatocellular Carcinoma Progression Through Regulating SLC1A5‐Mediated Tryptophan Metabolism (2024-12-08)
期刊：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 ：4.3
引用产品： SK-Hep-1 细胞 , HuH-7 细胞
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Endoplasmic Reticulum Membrane Protein Complex Regulates Cancer Stem Cells and is Associated with Sorafenib Resistance in Hepatocellular Carcinoma (2024-08-09)
期刊：Journal of Hepatocellular Carcinoma
影响因子 ：4.2
引用产品： HuH-7 细胞 , SK-Hep-1 细胞
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miR-10b-5p promotes tumor growth by regulating cell metabolism in liver cancer via targeting SLC38A2 (2024-02-23)
期刊：CANCER BIOLOGY & THERAPY
DOI：10.1080/15384047.2024.2315651
影响因子 ：3.6
引用产品： HL-7702 [L-02; LO2] 细胞 , HuH-7 细胞 , Hep G2 细胞 , Hep 3B2.1-7 细胞 , SMMC-7721 细胞 , SK-Hep-1 细胞
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Identification of Clinical Value and Biological Effects of XIRP2 Mutation in Hepatocellular Carcinoma (2024-08-19)
期刊：Biology-Basel
影响因子 ：3.6
引用产品： SK-Hep-1 细胞 , Hep G2 细胞 , HuH-7 细胞 , HuH-1 细胞 , Hep 3B2.1-7 细胞
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LINC02987 suppression hepatocellular carcinoma progression by modulating autophagy via the miR-338-3p/ATG12 axis (2024-12-31)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2024.114398
影响因子 ：3.3
引用产品： HuH-7 细胞 , Li-7 细胞 , THLE-2 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞 , Hep G2 细胞
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ZNF131 facilitates the growth of hepatocellular carcinoma by acting as a transcriptional activator of SMC4 expression (2024-01-11)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2024.149515
影响因子 ：3.1
引用产品： HuH-7 细胞 , Li-7 细胞 , JHH-7 细胞 , SK-Hep-1 细胞
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Quercetin inhibits endothelial & hepatocellular carcinoma cell crosstalk via reducing extracellular vesicle-mediated VEGFR2 mRNA transfer (2024-08-22)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23807
影响因子 ：3.0
引用产品： HuH-7 细胞 , SK-Hep-1 细胞 , PUMC-HUVEC-T1 细胞 , PUMC-HUVEC-T1细胞专用培养基
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Circ_0084615 promotes epithelial-mesenchymal transition-mediated tumor progression in hepatocellular carcinoma (2024-06-03)
期刊：Annals of Gastroenterological Surgery
影响因子 ：2.9
引用产品： MHCC97-L 细胞 , Hep 3B2.1-7 细胞 , THLE-2 细胞 , BEL-7405 细胞 , SK-Hep-1 细胞
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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate (2023-09-19)
期刊：CELL RESEARCH
DOI：10.1038/s41422-023-00874-4
影响因子 ：44.1
引用产品： SK-Hep-1 细胞
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5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I (2023-03-28)
期刊：Frontiers of Medicine
影响因子 ：8.1
引用产品： HuH-7 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞 , Li-7 细胞
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In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma (2023-09-04)
期刊：Cell Death Discovery
DOI：10.1038/s41420-023-01630-8
影响因子 ：7.0
引用产品： Hep G2 细胞 , SK-Hep-1 细胞
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Dual role of PID1 in regulating apoptosis induced by distinct anticancer-agents through AKT/Raf-1-dependent pathway in hepatocellular carcinoma (2023-04-28)
期刊：Cell Death Discovery
DOI：10.1038/s41420-023-01405-1
影响因子 ：7.0
引用产品： Hep G2 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞
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A novel class of C14-sulfonate-tetrandrine derivatives as potential chemotherapeutic agents for hepatocellular carcinoma (2023-01-10)
期刊：Frontiers in Chemistry
DOI：10.3389/fchem.2022.1107824
影响因子 ：5.5
引用产品： Hep G2 细胞 , SMMC-7721 细胞 , SK-Hep-1 细胞 , QGY-7701 细胞
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PI3K δ inhibitor PI-3065 induces apoptosis in hepatocellular carcinoma cells by targeting survivin (2023-01-06)
期刊：CHEMICO-BIOLOGICAL INTERACTIONS
影响因子 ：5.1
引用产品： SK-Hep-1 细胞 , Hep G2 细胞
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Pan-cancer analysis of 60S Ribosomal Protein L7-Like 1 (RPL7L1) and validation in liver hepatocellular carcinoma (2023-12-01)
期刊：Translational Oncology
DOI：10.1016/j.tranon.2023.101844
影响因子 ：5.0
引用产品： SK-Hep-1 细胞 , HuH-7 细胞
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Tumor purity–associated genes influence hepatocellular carcinoma prognosis and tumor microenvironment (2023-06-26)
期刊：Frontiers in Oncology
影响因子 ：4.7
引用产品： Hep G2 细胞 , SK-Hep-1 细胞 , HuH-1 细胞 , LX-2 细胞
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System analysis based on the lysosome-related genes identifies HPS4 as a novel therapy target for liver hepatocellular carcinoma (2023-09-13)
期刊：Frontiers in Oncology
影响因子 ：4.7
引用产品： SK-Hep-1 细胞 , HuH-7 细胞
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Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC (2023-03-15)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23526
影响因子 ：4.6
引用产品： HuH-7 细胞 , Hep G2 细胞 , HCCLM3 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞 , MHCC97-L 细胞
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Humanized disulfide-stabilized diabody against fibroblast growth factor-2 inhibits PD-L1 expression and epithelial-mesenchymal transition in hepatoma cells through STAT3 (2023-07-25)
期刊：IUBMB LIFE
DOI：10.1002/iub.2766
影响因子 ：4.6
引用产品： SK-Hep-1 细胞 , Hep G2 细胞
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Identify GADD45G as a potential target of 4-methoxydalbergione in treatment of liver cancer: bioinformatics analysis and in vivo experiment (2023-10-13)
期刊：World Journal of Surgical Oncology
DOI：10.1186/s12957-023-03214-3
影响因子 ：3.2
引用产品： SK-Hep-1 细胞
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NFYAv1 is a Tumor-Promoting Transcript Associated with Poor Prognosis of Hepatocellular Carcinoma (2023-01-21)
期刊：MEDICAL SCIENCE MONITOR
影响因子 ：3.1
引用产品： SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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Immunological function and prognostic value of lymphoid-specific helicase in liver hepatocellular carcinoma (2023-07-24)
期刊：Cancer Biomarkers
影响因子 ：3.1
引用产品： SK-Hep-1 细胞 , HuH-7 细胞 , SNU-387 细胞
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Prognostic and Immune Infiltration Analysis of Transaldolase 1 (TALDO1) in Hepatocellular Carcinoma (2023-12-31)
期刊：International Journal of General Medicine
影响因子 ：2.3
引用产品： SK-Hep-1 细胞
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Nanoparticle-Stabilized Emulsion Bioink for Digital Light Processing Based 3D Bioprinting of Porous Tissue Constructs (2022-03-04)
期刊：Advanced Healthcare Materials
影响因子 ：11.1
引用产品： NIH/3T3 细胞 , C2C12 细胞 , SK-Hep-1 细胞
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ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression (2022-08-01)
期刊：International Journal of Biological Sciences
影响因子 ：10.8
引用产品： HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞 , Hep G2 细胞 , H22 细胞 , THP-1 细胞
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ncRNAs-mediated high expression of TICRR promotes tumor cell proliferation and migration and is correlated with poor prognosis and tumor immune infiltration of hepatocellular carcinoma (2022-09-19)
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2022.09.007
影响因子 ：10.2
引用产品： SK-Hep-1 细胞 , HuH-7 细胞
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S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway (2022-08-16)
期刊：Cell Reports
DOI：10.1016/j.celrep.2022.111194
影响因子 ：10.0
引用产品： SK-Hep-1 细胞 , Hep G2 细胞 , 293T [HEK-293T] 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞
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IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma (2022-12-22)
期刊：Frontiers in Immunology
影响因子 ：8.8
引用产品： MHCC97-L 细胞 , HCCLM3 细胞 , Hep G2 细胞 , SK-Hep-1 细胞 , SNU-387 细胞 , MIHA 细胞
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SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma (2022-11-15)
期刊：Biomarker Research
DOI：10.1186/s40364-022-00422-z
影响因子 ：8.6
引用产品： SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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Identification and analysis of C17orf53 as a prognostic signature for hepatocellular carcinoma (2022-11-28)
期刊：COMPUTERS IN BIOLOGY AND MEDICINE
DOI：10.1016/j.compbiomed.2022.106348
影响因子 ：6.7
引用产品： SK-Hep-1 细胞
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Transfer RNA‐derived fragment 5′tRF‐Gly promotes the development of hepatocellular carcinoma by direct targeting of carcinoembryonic antigen‐related cell adhesion molecule 1 (2022-08-16)
期刊：CANCER SCIENCE
影响因子 ：6.5
引用产品： Hep 3B2.1-7 细胞 , 293T/17 细胞 , Li-7 细胞 , HuH-7 细胞 , SK-Hep-1 细胞 , Hep G2 细胞
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VEZF1, destabilized by STUB1, affects cellular growth and metastasis of hepatocellular carcinoma by transcriptionally regulating PAQR4 (2022-10-14)
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00540-8
影响因子 ：5.9
引用产品： SK-Hep-1 细胞 , PLC/PRF/5 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞
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CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex (2022-01-27)
期刊：Cancer Gene Therapy
DOI：10.1038/s41417-021-00423-4
影响因子 ：5.9
引用产品： Li-7 细胞 , SNU-182 细胞 , SNU-387 细胞 , HuH-7 细胞 , SK-Hep-1 细胞
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Improving the antitumor efficiency against hepatocellular carcinoma by harmine-loaded liposomes with mitochondria targeting and legumain response (2022-08-01)
期刊：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI：10.1016/j.jddst.2022.103623
影响因子 ：5.1
引用产品： SK-Hep-1 细胞
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Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/β-catenin signaling pathway (2022-02-07)
期刊：Drug Development Research
影响因子 ：5.0
引用产品： HuH-7 细胞 , SK-Hep-1 细胞
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Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma (2022-01-25)
期刊：Kaohsiung Journal of Medical Sciences
影响因子 ：3.3
引用产品： HuH-7 细胞 , SK-Hep-1 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway (2021-11-27)
期刊：Cellular & Molecular Biology Letters
DOI：10.1186/s11658-021-00295-4
影响因子 ：8.3
引用产品： HCCLM3 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞
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Bufalin enhances the killing efficacy of NK cells against hepatocellular carcinoma by inhibiting MICA shedding (2021-10-19)
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2021.108195
影响因子 ：5.7
引用产品： SK-Hep-1 细胞 , Hep G2 细胞 , NK-92MI 细胞 , NK-92MI细胞专用培养基
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Celecoxib reduces hepatic vascular resistance in portal hypertension by amelioration of endothelial oxidative stress (2021-10-05)
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.3
引用产品： SK-Hep-1 细胞
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PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway (2021-10-30)
期刊：Acta Biochimica Et Biophysica Sinica
影响因子 ：3.5
引用产品： HuH-7 细胞 , SK-Hep-1 细胞 , PLC/PRF/5 细胞
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Targeting Hedgehog signalling in CD133-positive hepatocellular carcinoma: improving Lenvatinib therapeutic efficiency (2021-03-17)
期刊：MEDICAL ONCOLOGY
DOI：10.1007/s12032-021-01487-w
影响因子 ：3.4
引用产品： Hep G2 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞
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Comprehensive analysis of ubiquitin‐specific protease 1 reveals its importance in hepatocellular carcinoma (2020-09-19)
期刊：Cell Proliferation
影响因子 ：8.5
引用产品： SK-Hep-1 细胞
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LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis (2020-09-16)
期刊：Cell Cycle
DOI：10.1080/15384101.2020.1809259
影响因子 ：4.3
引用产品： HuH-6 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞 , SNU-182 细胞
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Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis (2020-03-12)
期刊：Hepatobiliary & Pancreatic Diseases International
DOI：10.1016/j.hbpd.2020.02.011
影响因子 ：3.3
引用产品： HuH-6 细胞 , HuH-7 细胞 , SK-Hep-1 细胞
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Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells (2019-05-03)
期刊：EBioMedicine
DOI：10.1016/j.ebiom.2019.04.050
影响因子 ：11.1
引用产品： SK-Hep-1 细胞
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Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer (2019-07-11)
期刊：Oncology Reports
影响因子 ：4.2
引用产品： SK-Hep-1 细胞
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Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of Υ-synuclein in hepatocellular carcinoma cells (2016-12-27)
期刊：Oncotarget
影响因子 ：0.0
引用产品： Hep G2 细胞 , SK-Hep-1 细胞
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