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产品概述
| 名称 | HCCLM3 （人高转移肝癌细胞）（STR鉴定正确） |
| 别称 | LM3; MHCC-LM3; MHCCLM3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2 |
| 推荐换液频率 | 2-3天/次 |
| 背景描述 | HCCLM3细胞是一株由人肝癌细胞株MHCC97-H接种裸鼠、进行3次肺转移筛选、取肺转移瘤建成皮下接种后高度自发性肺转移的肝癌细胞系。HCCLM3细胞被广泛用于人肝癌发病机理的基础和临床研究，也可用于抗肿瘤药物筛选。 |
| 年龄（性别） | 男性；39岁 |
| 组织来源 | 肝；肝癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肝胆癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~72 hours |
| 保藏机构 | CCTCC; GDC0289 |
STR鉴定
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STR位点信息
Amelogenin X, Y CSF1PO 11,13 D2S1338 20 D3S1358 15,16 D5S818 12,13 D7S820 10 D8S1179 12,13 D13S317 8 D16S539 12 D18S51 13,22 D19S433 13,14 D21S11 31.2 FGA 21,24 PentaD 8,9 PentaE 17 TH01 9 TPOX 8 vWA 14 D6S1043 12,20 D12S391 18 D2S441 15 -
STR鉴定图
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参考文献
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Phase separation of EEF1E1 promotes tumor stemness via PTEN/AKT-mediated DNA repair in hepatocellular carcinoma (2025-01-28)
期刊：CANCER LETTERS
DOI：10.1016/j.canlet.2025.217508
影响因子 ：9.1
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hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p (2025-01-08)
期刊：Scientific Reports
DOI：10.1038/s41598-025-85737-1
影响因子 ：3.8
引用产品： HCCLM3 细胞 , MHCC97-L 细胞 , Hep G2 细胞 , SMMC-7721 细胞 , HuH-7 细胞
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AKT activation participates in Fascin-1-induced EMT in hepatoma cells (2025-01-25)
期刊：CYTOTECHNOLOGY
DOI：10.1007/s10616-025-00707-9
影响因子 ：2.0
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Stabilization of TGF-β Receptor 1 by a Receptor-Associated Adaptor Dictates Feedback Activation of the TGF-β Signaling Pathway to Maintain Liver Cancer Stemness and Drug Resistance (2024-07-09)
期刊：Advanced Science
影响因子 ：14.3
引用产品： HCCLM3 细胞 , 293T [HEK-293T] 细胞
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Constructing a disulfidptosis-related prognostic signature of hepatocellular carcinoma based on single-cell sequencing and weighted co-expression network analysis (2024-05-17)
期刊：APOPTOSIS
DOI：10.1007/s10495-024-01968-z
影响因子 ：7.2
引用产品： Hep G2 细胞 , HuH-7 细胞 , MHCC97-L 细胞 , HCCLM3 细胞 , SK-Hep-1 细胞
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Design, Synthesis, and Antitumor Activity Evaluation of 2-Phenylthiazole-5-Carboxylic Acid Derivatives Targeting Transactivation Response RNA-Binding Protein 2 (2024-12-26)
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.4c02041
影响因子 ：6.8
引用产品： HCCLM3 细胞
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Enhanced NK cell activation via eEF2K-mediated potentiation of the cGAS–STING pathway in hepatocellular carcinoma (2024-02-05)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.111628
影响因子 ：5.6
引用产品： NK-92 细胞 , HCCLM3 细胞 , 人源NK细胞完全培养基
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USP24 promotes autophagy-dependent ferroptosis in hepatocellular carcinoma by reducing the K48-linked ubiquitination of Beclin1 (2024-10-08)
期刊：Communications Biology
DOI：10.1038/s42003-024-06999-5
影响因子 ：5.2
引用产品： Hep G2 细胞 , SMMC-7721 细胞 , HuH-7 细胞 , HCCLM3 细胞 , THLE-2 细胞
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Exosomal miR-3174 induced by hypoxia promotes angiogenesis and metastasis of hepatocellular carcinoma by inhibiting HIPK3 (2024-01-19)
期刊：iScience
DOI：10.1016/j.isci.2024.108955
影响因子 ：4.6
引用产品： Hep 3B2.1-7 细胞 , HCCLM3 细胞 , 293T [HEK-293T] 细胞
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Transcription factor E2F4 facilitates SUMOylation to promote HCC progression through interaction with LIN9 (2024-09-02)
期刊：INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子 ：4.5
引用产品： Hep G2 细胞 , HCCLM3 细胞 , HuH-7 细胞 , HuH-6 细胞 , PLC/PRF/5 细胞
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Role of autophagy-related genes in liver cancer prognosis (2024-05-03)
期刊：GENOMICS
DOI：10.1016/j.ygeno.2024.110852
影响因子 ：4.4
引用产品： MHCC97-L 细胞 , HuH-7 细胞 , 293T [HEK-293T] 细胞 , HCCLM3 细胞 , LX-2 细胞
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The extract of an herbal medicine Chebulae fructus inhibits hepatocellular carcinoma by suppressing the Apelin/APJ system (2024-05-30)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1413463
影响因子 ：4.4
引用产品： Hep G2 细胞 , PLC/PRF/5 细胞 , HuH-7 细胞 , HCCLM3 细胞 , Hep 3B2.1-7 细胞
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β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression (2024-05-30)
期刊：Human Cell
DOI：10.1007/s13577-024-01081-y
影响因子 ：4.3
引用产品： HuH-7 细胞 , HCCLM3 细胞 , 293T [HEK-293T] 细胞
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Prognostic Hypoxia-Angiogenesis-Related Gene Signature in Hepatocellular Carcinoma, in Which HILPDA Contributes to Tumor Progression (2024-08-26)
期刊：Journal of Inflammation Research
影响因子 ：4.2
引用产品： HL-7702 [L-02; LO2] 细胞 , HCCLM3 细胞 , 人脐静脉内皮细胞
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PART1 facilitates tumorigenesis and inhibits ferroptosis by regulating the miR-490-3p/SLC7A11 axis in hepatocellular carcinoma (2024-07-05)
期刊：Aging-US
影响因子 ：3.9
引用产品： HL-7702 [L-02; LO2] 细胞 , HCCLM3 细胞 , HuH-7 细胞
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Long non-coding RNA LINC01554 overexpression suppresses viability, migration, and invasion of liver cancer cells through regulating miR-148b-3p/EIF4E3 (2024-03-04)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e27319
影响因子 ：3.4
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Pan-cancer analysis of COL15A1: an immunological and prognostic biomarker (2024-08-01)
期刊：Discover Oncology
DOI：10.1007/s12672-024-01200-z
影响因子 ：2.8
引用产品： HCCLM3 细胞 , HuH-7 细胞 , Hep G2 细胞 , HL-7702 [L-02; LO2] 细胞
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Targeting USP8 Inhibits O-GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT (2023-10-22)
期刊：Advanced Science
影响因子 ：15.1
引用产品： HCCLM3 细胞 , Hep G2 细胞 , HuH-7 细胞 , BEL-7404 细胞 , Hep 3B2.1-7 细胞 , PLC/PRF/5 细胞 , 293T [HEK-293T] 细胞
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A Ubiquitin-Dependent Switch on MEF2D Senses Pro-Metastatic Niche Signals to Facilitate Intrahepatic Metastasis of Liver Cancer (2023-10-12)
期刊：Advanced Science
影响因子 ：15.1
引用产品： HCCLM3 细胞 , MHCC97-L 细胞
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Hypoxia-responsive lncRNA AC115619 encodes a micropeptide that suppresses m6A modifications and hepatocellular carcinoma progression (2023-06-16)
期刊：CANCER RESEARCH
DOI：10.1158/0008-5472.CAN-23-0337
影响因子 ：11.2
引用产品： HCCLM3 细胞
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USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization (2023-06-13)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05747-7
影响因子 ：9.0
引用产品： HCCLM3 细胞 , Hep G2 细胞 , 293T [HEK-293T] 细胞
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UCHL3 inhibits ferroptosis by stabilizing β-catenin and maintains stem-like properties of hepatocellular carcinoma cells (2023-12-12)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2023.11.030
影响因子 ：7.4
引用产品： 293T [HEK-293T] 细胞 , HCCLM3 细胞 , Hep G2 细胞
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Detection of CSTF2 by nano fluorescent probe and its correlation with malignant biological characteristics in liver cancer (2023-11-15)
期刊：American Journal of Cancer Research
DOI：PMID:38058835
影响因子 ：5.3
引用产品： HL-7702 [L-02; LO2] 细胞 , HCCLM3 细胞 , Hep 3B2.1-7 细胞
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F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner (2023-02-02)
期刊：Cancers
影响因子 ：5.2
引用产品： HCCLM3 细胞 , Hep G2 细胞 , HCC8910 细胞 , HuH-7 细胞 , HL-7702 [L-02; LO2] 细胞 , 特级胎牛血清
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Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC (2023-03-15)
期刊：MOLECULAR CARCINOGENESIS
DOI：10.1002/mc.23526
影响因子 ：4.6
引用产品： HuH-7 细胞 , Hep G2 细胞 , HCCLM3 细胞 , SK-Hep-1 细胞 , Hep 3B2.1-7 细胞 , MHCC97-L 细胞
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Comprehensive Analysis of NABP2 as a Prognostic Biomarker and Its Correlation with Immune Infiltration in Hepatocellular Carcinoma (2023-04-20)
期刊：Journal of Inflammation Research
影响因子 ：4.5
引用产品： HCCLM3 细胞
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Circular RNA circBNC2 facilitates glycolysis and stemness of hepatocellular carcinoma through the miR-217/high mobility group AT-hook 2 (HMGA2) axis. (2023-06-09)
期刊：Heliyon
DOI：10.1016/j.heliyon.2023.e17120
影响因子 ：4.0
引用产品： HL-7702 [L-02; LO2] 细胞 , HuH-7 细胞 , HCCLM3 细胞 , Hep 3B2.1-7 细胞
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BTF3 promotes proliferation and glycolysis in hepatocellular carcinoma by regulating GLUT1 (2023-06-29)
期刊：CANCER BIOLOGY & THERAPY
DOI：10.1080/15384047.2023.2225884
影响因子 ：3.6
引用产品： HuH-7 细胞 , HCCLM3 细胞 , DMEM高糖 培养基
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Development and validation of a ubiquitin–proteasome system gene signature for prognostic prediction and immune microenvironment evaluation in hepatocellular carcinoma (2023-07-25)
期刊：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI：10.1007/s00432-023-05189-w
影响因子 ：3.6
引用产品： Hep G2 细胞 , HuH-7 细胞 , MHCC97-L 细胞 , HCCLM3 细胞
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Propofol Inhibits Biological Function of Hepatocellular Carcinoma Cells through LINC00475-Mediated Sonic Hedgehog Pathway (2023-03-07)
期刊：PHARMACOLOGY
影响因子 ：3.1
引用产品： MHCC97-L 细胞 , HCCLM3 细胞
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The long noncoding RNA TINCR promotes self-renewal of human liver cancer stem cells through autophagy activation (2022-11-16)
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-05424-1
影响因子 ：9.7
引用产品： HCCLM3 细胞 , MHCC97-L 细胞
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IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma (2022-12-22)
期刊：Frontiers in Immunology
影响因子 ：8.8
引用产品： MHCC97-L 细胞 , HCCLM3 细胞 , Hep G2 细胞 , SK-Hep-1 细胞 , SNU-387 细胞 , MIHA 细胞
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A comprehensively prognostic and immunological analysis of actin-related protein 2/3 complex subunit 5 in pan-cancer and identification in hepatocellular carcinoma (2022-09-06)
期刊：Frontiers in Immunology
影响因子 ：8.8
引用产品： MHCC97-L 细胞 , HuH-7 细胞 , Hep G2 细胞 , HCCLM3 细胞
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Overcoming the resistance of hepatocellular carcinoma to PD-1/PD-L1 inhibitor and the resultant immunosuppression by CD38 siRNA-loaded extracellular vesicles (2022-12-26)
期刊：OncoImmunology
DOI：10.1080/2162402X.2022.2152635
影响因子 ：7.7
引用产品： HuH-7 细胞 , HCCLM3 细胞 , MHCC97-L 细胞 , RPMI-1640 培养基 , BNL 1ME A.7R.1 细胞 , DMEM高糖 培养基 , 小鼠骨髓间充质干细胞 , Hank's平衡盐溶液 (HBSS)，含钙、镁，不含酚红
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A comprehensive prognostic and immunological analysis of ephrin family genes in hepatocellular carcinoma. (2022-08-16)
期刊：Frontiers in Molecular Biosciences
影响因子 ：6.1
引用产品： HCCLM3 细胞 , MHCC97-L 细胞 , SMMC-7721 细胞 , HuH-7 细胞 , Hep G2 细胞
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SLC39A10 Upregulation Predicts Poor Prognosis, Promotes Proliferation and Migration, and Correlates with Immune Infiltration in Hepatocellular Carcinoma (2022-11-14)
期刊：Journal of Hepatocellular Carcinoma
影响因子 ：5.0
引用产品： MHCC97-L 细胞 , HCCLM3 细胞 , Hep G2 细胞 , HL-7702 [L-02; LO2] 细胞 , PLC/PRF/5 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞
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FXR1 promotes proliferation, invasion and migration of hepatocellular carcinoma in?vitro and in?vivo (2022-11-22)
期刊：Oncology Letters
影响因子 ：3.1
引用产品： HuH-7 细胞 , HCCLM3 细胞 , MHCC97-L 细胞 , Hep 3B2.1-7 细胞
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LncRNA SNHG6 promotes glycolysis reprogramming in hepatocellular carcinoma by stabilizing the BOP1 protein (2022-12-06)
期刊：Animal Cells and Systems
DOI：10.1080/19768354.2022.2134206
影响因子 ：2.4
引用产品： HL-7702 [L-02; LO2] 细胞 , Hep G2 细胞 , SMMC-7721 细胞 , HCCLM3 细胞
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Hsa_circ_0048674 facilitates hepatocellular carcinoma progression and natural killer cell exhaustion depending on the regulation of miR-223-3p/PDL1 (2022-12-01)
期刊：HISTOLOGY AND HISTOPATHOLOGY
影响因子 ：2.1
引用产品： HCCLM3 细胞 , 人脐静脉内皮细胞 , DMEM高糖 培养基 , 特级胎牛血清 , HuH-7 细胞 , 青霉素-链霉素溶液（双抗），100× , RPMI-1640 培养基
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lncRNA PRR34-AS1 promotes HCC development via modulating Wnt/β-catenin pathway by absorbing miR-296-5p and upregulating E2F2 and SOX12 (2021-04-24)
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.04.016
影响因子 ：8.8
引用产品： HCCLM3 细胞
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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway (2021-11-27)
期刊：Cellular & Molecular Biology Letters
DOI：10.1186/s11658-021-00295-4
影响因子 ：8.3
引用产品： HCCLM3 细胞 , HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞
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CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression (2021-04-27)
期刊：European Journal Of Clinical Investigation
影响因子 ：5.5
引用产品： HCCLM3 细胞
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CCAT2 enhances autophagy-related invasion and metastasis via regulating miR-4496 and ELAVL1 in hepatocellular carcinoma (2021-08-24)
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.3
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Ultrasound-Targeted Microbubble Destruction-Mediated Downregulation of EZH2 Inhibits Stemness and Epithelial-Mesenchymal Transition of Liver Cancer Stem Cells (2021-01-11)
期刊：OncoTargets and Therapy
影响因子 ：4.4
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ZSCAN16-AS1 expedites hepatocellular carcinoma progression via modulating the miR-181c-5p/SPAG9 axis to activate the JNK pathway (2021-06-07)
期刊：Cell Cycle
DOI：10.1080/15384101.2021.1919828
影响因子 ：4.3
引用产品： HCCLM3 细胞 , Hep 3B2.1-7 细胞 , HuH-7 细胞
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AC093797.1 as a Potential Biomarker to Indicate the Prognosis of Hepatocellular Carcinoma and Inhibits Cell Proliferation, Invasion, and Migration by Reprogramming Cell Metabolism and Extracellular Matrix Dynamics (2021-12-03)
期刊：Frontiers in Genetics
影响因子 ：3.7
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circ-PRKCI targets miR-1294 and miR-186-5p by?downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma (2021-04-21)
期刊：Molecular Medicine Reports
影响因子 ：3.4
引用产品： HCCLM3 细胞
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HIF1A activates the transcription of lncRNA RAET1K to modulate hypoxia-induced glycolysis in hepatocellular carcinoma cells via miR-100-5p (2020-03-09)
期刊：Cell Death & Disease
影响因子 ：9.0
引用产品： HCCLM3 细胞
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LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma (2020-05-21)
期刊：Naunyn-Schmiedebergs Archives of Pharmacology
DOI：10.1007/s00210-020-01889-z
影响因子 ：3.6
引用产品： HCCLM3 细胞 , SMMC-7721 细胞
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CXCL14 inhibits the growth and promotes apoptosis of hepatocellular carcinoma cells via suppressing Akt/mTOR pathway (2020-10-27)
期刊：Journal Of Receptors And Signal Transduction
DOI：10.1080/10799893.2020.1837870
影响因子 ：2.8
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Curcumin Inhibits Hepatocellular Carcinoma via Regulating miR-21/TIMP3 Axis (2020-07-17)
期刊：Evidence-Based Complementary and Alternative Medicine
影响因子 ：2.7
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