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| 名称 | NCI-H292 (人肺癌细胞(淋巴结转移)) (STR鉴定正确) |
| 别称 | H292; H-292; NCI-HUT-292; Hut292; NCIH292 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | NCI-H292细胞源自肺支气管黏液上皮样癌的淋巴结转移灶；先用成份限定的培养基分离得到，然后换成含血清的培养基培养。培养条件下，NCI-H292细胞保留了黏液上皮的特性，可从其超微结构的表现和多种鳞状上皮分化标记的表达而判断。NCI-H292细胞支持HBV的生长，左旋多巴脱羧酶阴性。NCI-H292细胞可以作为筛选模型，将人类亚基因组片段转染入细胞来研究HBV及其自身基因在病毒性肝炎和肝癌发生中的作用。NCI-H292细胞角蛋白、波形蛋白、黏液洋红染色阳线，但神经丝三联蛋白阴性。 |
| 年龄（性别） | 女性；32岁 |
| 组织来源 | 肺粘膜上皮细胞癌；肺 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~48 hours |
| 致瘤性 | Yes, in nude mice; tumors histologically resemble the original biopsy specimen and retain mucoepidermoid features. |
| 基因表达情况 | keratin; vimentin,The cells retain their mucoepidermoid characteristics in culture as determined by their ultrastructure and expression of multiple markers of squamous differentiation. TANK cells show reactivity with human alloantisera specific for the HLA A1, A3, A10, A19, B12, B17, B22 and B40 cross-reactive groups. |
| 保藏机构 | ATCC; CRL-1848 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10 D2S1338 21,24 D3S1358 16 D5S818 13 D7S820 10 D8S1179 11,14 D13S317 11,12 D16S539 9,13 D18S51 16 D19S433 12,13.2 D21S11 28 FGA 22,26 PentaD 9 PentaE 13,15 TH01 8 TPOX 8,11 vWA 16,17 D6S1043 11,12 D12S391 16,20 D2S441 11,12 -
STR鉴定图
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参考文献
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Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer (2023-11-10)
作者：Li Zhang:1.Thoracic Surgery Laboratory, Xuzhou Medical University, Xuzhou, 221006, Jiangsu Province, China. ; 2.Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, 221006, Jiangsu Province, China. ; Jingtian Liang:1.Thoracic Surgery Laboratory, Xuzhou Medical University, Xuzhou, 221006, Jiangsu Province, China. ; 2.Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, 221006, Jiangsu Province, China. ; Hao Qin:1.Thoracic Surgery Laboratory, Xuzhou Medical University, Xuzhou, 221006, Jiangsu Province, China. ; 2.Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, 221006, Jiangsu Province, China. ; Yin Lv:1.Thoracic Surgery Laboratory, Xuzhou Medical University, Xuzhou, 221006, Jiangsu Province, China. ; 2.Department of Thoracic Surgery, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, X
期刊：Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer
DOI：10.1186/s13046-023-02875-y
影响因子 ：11.3
引用产品： A549 [A-549] 细胞 , NCI-H1299 细胞 , NCI-H292 细胞 , NCI-H23 细胞 , NCI-H1703 细胞 , NCI-H226 [H226] 细胞 , BEAS-2B 细胞
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Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease (2023-11-03)
作者：Yuanjie Hao:1.Graduate School, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. ; Tongxing Wang:1.Hebei Academy of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, 050035, Hebei, China. ; 2.National Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China. ; Yunlong Hou:1.Hebei Academy of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, 050035, Hebei, China. ; 2.National Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China. ; Xiaoqi Wang:1.Graduate School, Hebei University of Chinese Medicine, Shijiazhuan, 050090, Hebei, China. ; Yujie Yin:1.Hebei Academy of Integrated Traditional Chinese and Western Medicine, Shijiazhuang, 050035, Hebei, China. ; 2.National Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, 050035, China. ; Yi Liu:1.Graduate School, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. ; Ningxin
期刊：Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease
DOI：10.1186/s13020-023-00851-4
影响因子 ：4.9
引用产品： NCI-H292 细胞
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Tanshinone IIA (TSIIA) represses the progression of non-small cell lung cancer by the circ_0020123/miR-1299/HMGB3 pathway (2022-12-31)
作者：Fei Sun:1.Department of Pharmacy, Yantai Hospital of Traditional Chinese Medicine, 39 Xingfu Road, Zhifu District, Yantai, 264000, Shandong, China. ; Xiaoli Yang:1.Department of Pharmacy, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China. ; Wei Song:1.Qingdao Central Hospital Drug Purchasing Office, Qingdao, Shandong, China. ; Nan Yu:1.Department of Pharmacy, Qingdao Eighth People's Hospital, Qingdao, Shandong, China. ; Qingyi Lin:1.Department of Pharmacy, Yantai Hospital of Traditional Chinese Medicine, 39 Xingfu Road, Zhifu District, Yantai, 264000, Shandong, China. xiaoajh2020@163.com. ;
期刊：Tanshinone IIA (TSIIA) represses the progression of non-small cell lung cancer by the circ_0020123/miR-1299/HMGB3 pathway
DOI：10.1007/s11010-022-04646-3
影响因子 ：3.8
引用产品： A549 [A-549] 细胞 , NCI-H292 细胞 , Ham's F-12K 培养基 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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LINC00173.v1 Promotes Angiogenesis and Progression of Lung Squamous Cell Carcinoma by Sponging miR-511-5p to Regulate VEGFA Expression (2007-00-20)
作者：Jiarong Chen:1.Clinical Experimental Center, Jiangmen Key Laboratory of Clinical Biobanks and Translational Research, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, China. ; 2.Department of Oncology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, China. ; Aibin Liu:1.Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, 410008, China. ; 2.National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China. ; Zhihui Wang:1.Department of Oncology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, China. ; Bin Wang:1.Clinical Experimental Center, Jiangmen Key Laboratory of Clinical Biobanks and Translational Research, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat-sen University, Jiangmen, 529030, China. ; 2.Dongguan Key Labor
期刊：LINC00173.v1 Promotes Angiogenesis and Progression of Lung Squamous Cell Carcinoma by Sponging miR-511-5p to Regulate VEGFA Expression
DOI：10.1186/s12943-020-01217-2
影响因子 ：37.3
引用产品： A549 [A-549] 细胞 , Calu-1 细胞 , NCI-H460 [H460] 细胞 , NCI-H292 细胞
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Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression (2011-00-20)
作者：Yaying Yu:1.Department of Nutrition, The First Affiliated Hospital of Henan University, Kaifeng, China. ; Yanwei Xing:1.Department of Pediatrics, Kaifeng Hospital of Traditional Chinese Medicine, Kaifeng, China. ; Qian Zhang:1.Department of Laboratory Medicine, The First Affiliated Hospital of Henan University, Kaifeng, China. ; Qianqian Zhang:1.Department of Endocrinology, The First Affiliated Hospital of Henan University, Kaifeng, China. ; Shuangjian Huang:1.Department of Nutrition, The First Affiliated Hospital of Henan University, Kaifeng, China. ; Xinxin Li:1.Department of Nutrition, The First Affiliated Hospital of Henan University, Kaifeng, China. ; Chao Gao:1.Department of Scientific Research, The First Affiliated Hospital of Henan University, Kaifeng, China. ;
期刊：Soy isoflavone genistein inhibits hsa_circ_0031250/miR‐873‐5p/FOXM1 axis to suppress non‐small‐cell lung cancer progression
DOI：10.1002/iub.2404
影响因子 ：4.6
引用产品： 16HBE 细胞 , NCI-H292 细胞 , A549 [A-549] 细胞
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