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产品概述
名称 | LN229 [LN-229; LNT-229] (人胶质母细胞瘤细胞) (STR鉴定正确) |
别称 | LN 229; LN229; LNT-229 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:3-1:5 |
推荐换液频率 | 2-3次/周 |
背景描述 | The LN-229 cell line was Established in 1979 from cells taken from a patient with right frontal parieto-occipital glioblastoma [PubMed. 10416987]. |
年龄(性别) | 女性;60岁 |
组织来源 | 大脑/右额叶顶枕叶皮质 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 胶质母细胞瘤细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~31 hours |
致瘤性 | Yes, forms tumors in nude mice. |
保藏机构 | ATCC; CRL-2611 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 19,20 D3S1358 16,17 D5S818 11,12 D7S820 8,11 D8S1179 13,14 D13S317 10,11 D16S539 12 D18S51 13,15 D19S433 12,17.2 D21S11 29,30 FGA 23 PentaD 10,11 PentaE 7,16 TH01 9.3 TPOX 8 vWA 16,19 D6S1043 11 D12S391 20,22 D2S441 10,11 -
STR鉴定图
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参考文献
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NONHSAT141192.2 Facilitates the Stemness and Radioresistance of Glioma Stem Cells via the Regulation of PIK3R3 and SOX2 (2025-02-19)
期刊:CNS Neuroscience & Therapeutics
影响因子 :4.8
引用产品: LN229 [LN-229; LNT-229] 细胞 , U251 细胞
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SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Other Cancer Types: A Pan-Cancer Study (2025-02-13)
期刊:Journal of Inflammation Research
影响因子 :4.2
引用产品: U251 细胞 , LN229 [LN-229; LNT-229] 细胞 , U-87 MG 细胞 , A172 细胞 , T98G 细胞 , 人神经星形胶质细胞
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ARMC10 Drives Glioblastoma Progression Through Activating Notch Pathway (2025-02-23)
期刊:MOLECULAR CARCINOGENESIS
DOI:10.1002/mc.23895
影响因子 :3.0
引用产品: A172 细胞 , U251 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , U-87 MG 细胞 , 青霉素-链霉素溶液(双抗),100× , MEM(含NEAA) 培养基
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Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia (2024-03-30)
期刊:NEURO-ONCOLOGY
影响因子 :15.9
引用产品: LN229 [LN-229; LNT-229] 细胞 , SF126 细胞 , U-87 MG 细胞 , HMC3 细胞 , BV2 细胞
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Sequential Release HydroLipo System for STING Gene Epigenetic Reprogramming and Immune Activation in Glioblastoma (2024-12-11)
期刊:Advanced Science
影响因子 :14.3
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Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles (2024-10-07)
期刊:Theranostics
影响因子 :12.4
引用产品: LN229 [LN-229; LNT-229] 细胞 , U-118 MG 细胞 , U251 细胞 , T98G 细胞 , A172 细胞 , THP-1 细胞
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Hsa_circ_0021205 enhances lipolysis via regulating miR-195-5p/HSL axis and drives malignant progression of glioblastoma (2024-02-10)
期刊:Cell Death Discovery
DOI:10.1038/s41420-024-01841-7
影响因子 :7.0
引用产品: SNB-19 细胞 , LN229 [LN-229; LNT-229] 细胞 , U251 细胞 , T98G 细胞 , U-87 MG 细胞
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EZH2–STAT3 signaling pathway regulates GSDMD-mediated pyroptosis in glioblastoma (2024-07-28)
期刊:Cell Death Discovery
DOI:10.1038/s41420-024-02105-0
影响因子 :6.1
引用产品: U-87 MG 细胞 , A172 细胞 , HA1800 细胞 , H4 细胞 , LN229 [LN-229; LNT-229] 细胞
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Immune cell infiltration and drug response in glioblastoma multiforme: insights from oxidative stress-related genes (2024-04-02)
期刊:Cancer Cell International
DOI:10.1186/s12935-024-03316-2
影响因子 :5.8
引用产品: 人神经星形胶质细胞 , LN229 [LN-229; LNT-229] 细胞 , U251 细胞 , U-87 MG 细胞
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A label-free electrochemical biosensor based on graphene quantum dots-nanoporous gold nanocomposite for highly sensitive detection of glioma cell (2024-12-16)
期刊:ANALYTICA CHIMICA ACTA
影响因子 :5.7
引用产品: U251 细胞 , NIH/3T3 细胞 , SCC7 细胞 , 4T1 细胞 , B16-F10 细胞 , Hela 细胞 , Hep G2 细胞 , LN229 [LN-229; LNT-229] 细胞 , PC-9 细胞 , LLC [LL/2; LLC1] 细胞 , hCMEC/D3 细胞 , HL-7702 [L-02; LO2] 细胞
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Prognosis and therapeutic significance of IGF-1R-related signaling pathway gene signature in glioma (2024-04-11)
期刊:Frontiers in Cell and Developmental Biology
DOI:10.3389/fcell.2024.1375030
影响因子 :5.5
引用产品: LN229 [LN-229; LNT-229] 细胞 , U251 细胞 , T98G 细胞
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A novel immunogenic cell death-related gene risk signature can identify biomarkers of gliomas and predict the immunotherapeutic response (2024-01-15)
期刊:American Journal of Cancer Research
DOI:PMID:38323285
影响因子 :5.3
引用产品: U251 细胞 , LN229 [LN-229; LNT-229] 细胞
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TBX15 facilitates malignant progression of glioma by transcriptional activation of TXDNC5 (2024-01-18)
期刊:iScience
DOI:10.1016/j.isci.2024.108950
影响因子 :4.6
引用产品: 人神经星形胶质细胞 , U-118 MG 细胞 , A172 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , U251 细胞 , THP-1 细胞
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Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma (2024-03-11)
期刊:CELLULAR SIGNALLING
DOI:10.1016/j.cellsig.2024.111137
影响因子 :4.4
引用产品: U-87 MG 细胞 , LN229 [LN-229; LNT-229] 细胞 , A172 细胞 , H4 细胞
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TIFA enhances glycolysis through E2F1 and promotes the progression of glioma (2024-10-29)
期刊:CELLULAR SIGNALLING
DOI:10.1016/j.cellsig.2024.111498
影响因子 :4.4
引用产品: A172 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , U251 细胞
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CBX2 enhances the progression and TMZ chemoresistance of glioma via EZH2-mediated epigenetic silencing of PTEN expression (2024-07-24)
期刊:Frontiers in Pharmacology
DOI:10.3389/fphar.2024.1430891
影响因子 :4.4
引用产品: T98G 细胞 , 青霉素-链霉素溶液(双抗),100× , A172 细胞 , DMEM高糖 培养基 , LN229 [LN-229; LNT-229] 细胞
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Repurposing flubendazole for glioblastoma ferroptosis by affecting xCT and TFRC proteins (2024-11-14)
期刊:JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 :4.3
引用产品: U251 细胞 , LN229 [LN-229; LNT-229] 细胞
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Exploration of the biological mechanisms of CENPA as an oncogene in glioma: Screening based on cancer functional status (2024-12-02)
期刊:JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 :4.3
引用产品: LN229 [LN-229; LNT-229] 细胞 , U251 细胞
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Phospholipid scramblase 1 acts through the IL-6/JAK/STAT3 pathway to promote the malignant progression of glioma (2024-04-16)
期刊:ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
影响因子 :3.9
引用产品: A172 细胞 , T98G 细胞 , U251 细胞 , LN229 [LN-229; LNT-229] 细胞 , U-87 MG 细胞
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Transcription factor YY1-activated GNG5 facilitates glioblastoma cell growth, invasion, stemness and glycolysis through Wnt/β-catenin pathway (2024-10-24)
期刊:Scientific Reports
DOI:10.1038/s41598-024-76019-3
影响因子 :3.8
引用产品: U251 细胞 , LN229 [LN-229; LNT-229] 细胞 , A172 细胞 , 人神经星形胶质细胞
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Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway (2024-03-28)
期刊:JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI:10.1007/s00432-024-05625-5
影响因子 :3.6
引用产品: LN229 [LN-229; LNT-229] 细胞 , U-87 MG 细胞
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Comprehensive pan-cancer analysis of ACSS3 as a biomarker for prognosis and immunotherapy response (2024-07-27)
期刊:Heliyon
DOI:10.1016/j.heliyon.2024.e35231
影响因子 :3.4
引用产品: 人神经星形胶质细胞 , U251 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , U-87 MG 细胞
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TMEM17 Promotes Tumor Progression in Glioblastoma by Activating the PI3K/AKT Pathway (2024-08-16)
期刊:Frontiers in Bioscience-Landmark
影响因子 :3.3
引用产品: LN229 [LN-229; LNT-229] 细胞 , U-87 MG 细胞
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Regulation of a novel circATP8B4/miR-31-5p/nestin ceRNA crosstalk in proliferation, motility, invasion and radiosensitivity of human glioma cells (2024-09-17)
期刊:JOURNAL OF RADIATION RESEARCH
影响因子 :1.9
引用产品: T98G 细胞 , HMC3 细胞 , U251 细胞 , A172 细胞 , LN229 [LN-229; LNT-229] 细胞
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NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis (2023-09-28)
期刊:Nature Communications
DOI:10.1038/s41467-023-41739-z
影响因子 :16.6
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Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression (2023-10-12)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2023.1236806
影响因子 :7.3
引用产品: Hep G2 细胞 , U251 细胞 , LN229 [LN-229; LNT-229] 细胞
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Nifuroxazide inhibits the growth of glioblastoma and promotes the infiltration of CD8 T cells to enhance antitumour immunity (2023-03-14)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2023.109987
影响因子 :5.6
引用产品: LN229 [LN-229; LNT-229] 细胞 , U251 细胞 , T98G 细胞 , A172 细胞 , 人脐静脉内皮细胞 , GL261 细胞 , BV2 细胞
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A TGF-β signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response (2023-10-18)
期刊:CNS Neuroscience & Therapeutics
影响因子 :5.5
引用产品: T98G 细胞 , U251 细胞 , LN229 [LN-229; LNT-229] 细胞
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The HNF4A-CHPF pathway promotes proliferation and invasion through interactions with MAD1L1 in glioma. (2023-10-17)
期刊:Aging-US
影响因子 :5.2
引用产品: U-118 MG 细胞 , U251 细胞 , U-87 MG 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , SVG 细胞 , 293T [HEK-293T] 细胞
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Tumor-suppressive function and mechanism of miR-873-5p in glioblastoma: evidence based on bioinformatics analysis and experimental validation (2023-06-28)
期刊:Aging-US
影响因子 :5.2
引用产品: 293T [HEK-293T] 细胞 , T98G 细胞 , U251 细胞 , LN229 [LN-229; LNT-229] 细胞 , A172 细胞
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Zinc finger and SCAN domain-containing 18 suppresses the proliferation, self-renewal, and drug resistance of glioblastoma cells (2023-06-03)
期刊:Heliyon
DOI:10.1016/j.heliyon.2023.e17000
影响因子 :4.0
引用产品: U251 细胞 , SHG-44 细胞 , LN229 [LN-229; LNT-229] 细胞 , U-87 MG 细胞
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Cordycepin improves sensitivity to temozolomide in glioblastoma cells by down-regulating MYC (2023-09-11)
期刊:JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI:10.1007/s00432-023-05347-0
影响因子 :3.6
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VSIG4 Silencing Inhibits Glioblastoma Growth by Regulating the JAK2/STAT3 Pathway (2023-06-02)
期刊:Neuropsychiatric Disease and Treatment
影响因子 :3.2
引用产品: U251 细胞 , LN229 [LN-229; LNT-229] 细胞 , U251细胞专用培养基 , LN229 [LN-229; LNT-229]细胞专用培养基
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HNF4G accelerates glioma progression by facilitating NRP1 transcription (2023-02-01)
期刊:Oncology Letters
影响因子 :2.9
引用产品: U-87 MG 细胞 , LN229 [LN-229; LNT-229] 细胞 , U251 细胞
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Cytotoxicity sesquiterpenoids from the leaves of Datura stramonium L. (2023-05-17)
期刊:NATURAL PRODUCT RESEARCH
DOI:10.1080/14786419.2023.2214292
影响因子 :2.2
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SLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma (2022-12-24)
期刊:Cell Death & Disease
DOI:10.1038/s41419-022-05526-w
影响因子 :9.7
引用产品: U-87 MG 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , U373 细胞 , HA1800 细胞 , THP-1 细胞
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RNA-binding protein DHX9 promotes glioma growth and tumor-associated macrophages infiltration via TCF12 (2022-11-15)
期刊:CNS Neuroscience & Therapeutics
影响因子 :7.0
引用产品: 人神经星形胶质细胞 , U251 细胞 , A172 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , U-118 MG 细胞 , THP-1 细胞
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A novel necroptosis-related gene signature for predict prognosis of glioma based on single-cell and bulk RNA sequencing (2022-08-30)
期刊:Frontiers in Molecular Biosciences
影响因子 :6.1
引用产品: U-118 MG 细胞 , U138 细胞 , LN229 [LN-229; LNT-229] 细胞 , HS 683 细胞 , U-118 MG细胞专用培养基 , U138 细胞专用培养基 , LN229 [LN-229; LNT-229]细胞专用培养基 , HS 683细胞专用培养基
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Propofol inhibits glioma progression by regulating circMAPK4/miR-622/HOXA9 axis (2022-11-03)
期刊:METABOLIC BRAIN DISEASE
DOI:10.1007/s11011-022-01099-x
影响因子 :3.7
引用产品: U251 细胞 , LN229 [LN-229; LNT-229] 细胞
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Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281 (2022-01-04)
期刊:Neurotoxicity Research
DOI:10.1007/s12640-021-00464-5
影响因子 :3.7
引用产品: LN229 [LN-229; LNT-229] 细胞 , U251 细胞
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Identification of pimavanserin tartrate as a potent Ca2+-calcineurin-NFAT pathway inhibitor for glioblastoma therapy (2021-08-06)
期刊:Acta Pharmacologica Sinica
DOI:10.1038/s41401-021-00724-2
影响因子 :8.2
引用产品: U-87 MG 细胞 , U-118 MG 细胞 , A172 细胞 , T98G 细胞 , LN229 [LN-229; LNT-229] 细胞 , MCF 10A 细胞
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Overexpressed XRCC2 as an independent risk factor for poor prognosis in glioma patients (2021-05-29)
期刊:Molecular Medicine
DOI:10.1186/s10020-021-00316-0
影响因子 :5.7
引用产品: HA 细胞 , Marcus 细胞 细胞 , A172 细胞 , U251 细胞
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Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis (2021-08-31)
期刊:Bioengineered
DOI:10.1080/21655979.2021.1976712
影响因子 :4.9
引用产品: LN229 [LN-229; LNT-229] 细胞 , T98G 细胞 , A172 细胞
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Knockdown of long non-coding RNA AGAP2-AS1 suppresses the proliferation and metastasis of glioma by targeting microRNA-497-5p (2021-10-28)
期刊:Bioengineered
DOI:10.1080/21655979.2021.1995573
影响因子 :4.9
引用产品: SHG-44 细胞 , LN229 [LN-229; LNT-229] 细胞 , DMEM高糖 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗),100×
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The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells (2021-11-18)
期刊:Frontiers in Oncology
影响因子 :4.7
引用产品: U-87 MG 细胞 , LN229 [LN-229; LNT-229] 细胞 , U251 细胞 , T98G 细胞
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CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis (2021-10-09)
期刊:Bmc Cancer
DOI:10.1186/s12885-021-08803-7
影响因子 :3.8
引用产品: SHG-44 细胞 , U251 细胞 , LN229 [LN-229; LNT-229] 细胞 , A172 细胞 , T98G 细胞
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CKAP2L, as an Independent Risk Factor, Closely Related to the Prognosis of Glioma (2021-09-28)
期刊:Biomed Research International
影响因子 :3.4
引用产品: 人神经星形胶质细胞 , LN229 [LN-229; LNT-229] 细胞 , T98G 细胞 , U251 细胞 , A172 细胞
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CircFOXM1 promotes the proliferation, migration, invasion, and glutaminolysis of glioblastoma by regulating the miR-577/E2F5 axis (2021-06-28)
期刊:Bosnian Journal of Basic Medical Sciences
影响因子 :3.4
引用产品: 青霉素-链霉素溶液 (双抗),100× , U251 细胞 , LN229 [LN-229; LNT-229] 细胞 , A172 细胞 , 人神经星形胶质细胞
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MSC-AS1 knockdown inhibits cell growth and temozolomide resistance by regulating miR-373-3p/CPEB4 axis in glioma through PI3K/Akt pathway (2020-10-26)
期刊:MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI:10.1007/s11010-020-03937-x
影响因子 :4.3
引用产品: SHG-44 细胞 , 293T [HEK-293T] 细胞 , LN229 [LN-229; LNT-229] 细胞
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Sevoflurane Represses Proliferation and Migration of Glioma Cells by Regulating the ANRIL/let-7b-5p Axis (2020-08-19)
期刊:Cancer Biother And Radiopharm
影响因子 :3.4
引用产品: U251 细胞 , LN229 [LN-229; LNT-229] 细胞
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CircTTBK2 Contributes to the Progression of Glioma Through Regulating miR-145-5p/CPEB4 Axis (2020-09-08)
期刊:Cancer Management and Research
影响因子 :3.3
引用产品: T98G 细胞 , LN229 [LN-229; LNT-229] 细胞
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