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产品概述
名称 | LLC [LL/2; LLC1] (小鼠肺癌细胞) (STR鉴定正确) |
别称 | LL/2 (LLc1); LL/2(LLc1); LL/2; LL2; LLC1; LLC; Lewis lung carcinoma line 1; Lewis lung carcinoma; Lewis-Lung; Lewis Lung |
种属 | 小鼠 |
生长特性 | 半贴半悬 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | LLC细胞是小鼠Lewis肺癌细胞。 |
年龄(性别) | 不详 |
组织来源 | 肺 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肺癌细胞 |
生物安全等级 | BSL-1 |
致瘤性 | Yes, in C57BL mice. |
抗原表达情况 | H-2b |
保藏机构 | ATCC; CRL-1642 BCRC; 60050 BCRJ; 0145 ECACC; 90020104 |
STR鉴定
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STR位点信息
18-3 15,16 6-7 15 5-5 16,17 X-1 25,26 1-2 18,19 7-1 27.2 8-1 16,17 1-1 15,16,17,18 19-2 13 15-3 24.3,25.3,26.3 12-1 17 6-4 18 4-2 21.3,23.3 3-2 13,14 2-1 16 13-1 18.1
11-2 13.3,14.3,15.3 17-2 14,15 -
STR鉴定图
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参考文献
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GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy (2025-01-01)
期刊:Journal for ImmunoTherapy of Cancer
影响因子 :10.3
引用产品: LLC [LL/2; LLC1] 细胞
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Neo-BCV: A Novel Bacterial Liquid Complex Vaccine for Enhancing Dendritic Cell-Mediated Immune Responses Against Lung Cancer (2025-01-13)
期刊:Vaccines
影响因子 :5.2
引用产品: LLC [LL/2; LLC1] 细胞
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UPLC-Q-TOF/MS-based serum metabolomics revealed anti-tumor mechanism of ethanol-soluble acidic components from Camellia oleifera cake and synergy with PD-1 inhibitor (2025-01-27)
期刊:Food Bioscience
DOI:10.1016/j.fbio.2025.106005
影响因子 :4.8
引用产品: LLC [LL/2; LLC1] 细胞
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Dual efficacy of tocilizumab in managing PD-1 inhibitors-induced myocardial inflammatory injury and suppressing tumor growth with PD-1 inhibitors: a preclinical study (2025-01-03)
期刊:CANCER IMMUNOLOGY IMMUNOTHERAPY
DOI:10.1007/s00262-024-03899-9
影响因子 :4.6
引用产品: LLC [LL/2; LLC1] 细胞 , RAW 264.7 细胞
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Luteolin-Zinc Modulates PRR11 Methylation and Ferroptosis in Lung Cancer Cells Under Hypoxia (2025-01-13)
期刊:Pharmacognosy Magazine
影响因子 :0.6
引用产品: LLC [LL/2; LLC1] 细胞
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A method for predicting drugs that can boost the efficacy of immune checkpoint blockade (2024-03-18)
期刊:NATURE IMMUNOLOGY
DOI:10.1038/s41590-024-01789-x
影响因子 :30.5
引用产品: LLC [LL/2; LLC1] 细胞
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Reprogramming exosomes for immunity-remodeled photodynamic therapy against non-small cell lung cancer (2024-05-21)
期刊:Bioactive Materials
DOI:10.1016/j.bioactmat.2024.05.030
影响因子 :18.0
引用产品: DC2.4 细胞 , B16-F10 细胞 , LLC [LL/2; LLC1] 细胞 , RAW 264.7 细胞
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UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment (2024-02-08)
期刊:Nature Communications
DOI:10.1038/s41467-024-45340-w
影响因子 :16.6
引用产品: HCC827 细胞 , LLC [LL/2; LLC1] 细胞 , HFL1 细胞 , THP-1 细胞 , Ham's F-12K 培养基 , HFL1细胞完全培养基
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Discovery of Lipoxygenase-Like Materials for Inducing Ferroptosis (2024-11-12)
期刊:ACS Nano
影响因子 :15.8
引用产品: LLC [LL/2; LLC1] 细胞
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Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape (2024-05-02)
期刊:Advanced Science
影响因子 :15.1
引用产品: LLC [LL/2; LLC1] 细胞 , NCI-H1650 细胞
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Lung-Targeted Lipid Nanoparticle-Delivered siUSP33 Attenuates SARS-CoV-2 Replication and Virulence by Promoting Envelope Degradation (2024-09-20)
期刊:Advanced Science
影响因子 :14.3
引用产品: LLC [LL/2; LLC1] 细胞 , AML12 细胞
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Engineered multienzyme-mimicking 2D bismuthene catalytic nanotriggers enable cascade enzyodynamic-boosted and synergistic GPX4/FSP1-mediated ferroptosis amplification for cancer radiosensitization (2024-11-19)
期刊:CHEMICAL ENGINEERING JOURNAL
影响因子 :13.3
引用产品: LLC [LL/2; LLC1] 细胞
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Environment-responsive dendrobium polysaccharide hydrogel embedding manganese microsphere as a post-operative adjuvant to boost cascaded immune cycle against melanoma (2024-06-17)
期刊:Theranostics
影响因子 :12.4
引用产品: LLC [LL/2; LLC1] 细胞
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Ultrasound-responsive nanocarriers with siRNA and Fe3O4 regulate macrophage polarization and phagocytosis for augmented non-small cell lung cancer immunotherapy (2024-10-07)
期刊:JOURNAL OF NANOBIOTECHNOLOGY
DOI:10.1186/s12951-024-02883-w
影响因子 :10.6
引用产品: RAW 264.7 细胞 , LLC [LL/2; LLC1] 细胞
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Nerve Growth Factor/Tyrosine Kinase A Receptor Pathway Enhances Analgesia in an Experimental Mouse Model of Bone Cancer Pain by Increasing Membrane Levels of δ-Opioid Receptors (2024-03-08)
期刊:ANESTHESIOLOGY
DOI:10.1097/ALN.0000000000004880
影响因子 :8.8
引用产品: LLC [LL/2; LLC1] 细胞
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Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis (2024-12-10)
期刊:ACS Applied Materials & Interfaces
影响因子 :8.3
引用产品: LLC [LL/2; LLC1] 细胞
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Preparation and antitumor activity of selenium nanocomposite stabilized by AAGL from Agerocybe aegerita (2024-10-29)
期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI:10.1016/j.ijbiomac.2024.137002
影响因子 :7.7
引用产品: A549 [A-549] 细胞 , NCI-H157 细胞 , PC-9 细胞 , LLC [LL/2; LLC1] 细胞
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Altingia chinensis petroleum ether extract suppresses NSCLC via induction of apoptosis, attenuation of EMT, and downregulation of PI3K/Akt pathway (2024-11-10)
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2024.156218
影响因子 :6.7
引用产品: NCI-H1299 细胞 , RPMI-1640 培养基 , LLC [LL/2; LLC1] 细胞
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A label-free electrochemical biosensor based on graphene quantum dots-nanoporous gold nanocomposite for highly sensitive detection of glioma cell (2024-12-16)
期刊:ANALYTICA CHIMICA ACTA
影响因子 :5.7
引用产品: U251 细胞 , NIH/3T3 细胞 , SCC7 细胞 , 4T1 细胞 , B16-F10 细胞 , Hela 细胞 , Hep G2 细胞 , LN229 [LN-229; LNT-229] 细胞 , PC-9 细胞 , LLC [LL/2; LLC1] 细胞 , hCMEC/D3 细胞 , HL-7702 [L-02; LO2] 细胞
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Cancer-educated neutrophils promote lung cancer progression via PARP-1-ALOX5-mediated MMP-9 expression (2024-01-02)
期刊:Cancer Biology & Medicine
DOI:10.20892/j.issn.2095-3941.2023.0248
影响因子 :5.6
引用产品: LLC [LL/2; LLC1] 细胞
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Bifunctional molecular probe targeting tumor PD-L1 enhances anti-tumor efficacy by promoting ferroptosis in lung cancer mouse model (2024-03-04)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2024.111781
影响因子 :5.6
引用产品: LLC [LL/2; LLC1] 细胞 , 特级胎牛血清
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Dynamic Changes of the Gut Microbiota and Its Functional Metagenomic Potential during the Development of Non-Small Cell Lung Cancer (2024-03-28)
期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 :5.6
引用产品: LLC [LL/2; LLC1] 细胞 , DMEM/F12 培养基
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Radiation-Induced Tumor-Derived Extracellular Vesicles Combined with Tyrosine Kinase Inhibitors: An Effective and Safe Therapeutic Approach for Lung Adenocarcinoma with EGFR19Del (2024-12-14)
期刊:Vaccines
影响因子 :5.2
引用产品: LLC [LL/2; LLC1] 细胞
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A novel selenium nanocomposite modified by AANL inhibits tumor growth by upregulating CLK2 in lung cancer (2024-05-15)
期刊:BIOORGANIC CHEMISTRY
DOI:10.1016/j.bioorg.2024.107459
影响因子 :5.1
引用产品: A549 [A-549] 细胞 , LLC [LL/2; LLC1] 细胞 , NCI-H1437 细胞 , NCI-H157 细胞
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Combinational delivery of TLR4 and TLR7/8 agonist enhanced the therapeutic efficacy of immune checkpoint inhibitors to colon tumor (2024-03-20)
期刊:MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI:10.1007/s11010-024-04966-6
影响因子 :4.3
引用产品: 4T1 细胞 , LLC [LL/2; LLC1] 细胞
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Cremastrae Pseudobulbus Pleiones Pseudobulbus (CPPP) Against Non-Small-Cell Lung Cancer: Elucidating Effective Ingredients and Mechanism of Action (2024-11-11)
期刊:Pharmaceuticals
影响因子 :4.3
引用产品: LLC [LL/2; LLC1] 细胞
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Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer (2024-12-06)
期刊:Journal of Inflammation Research
影响因子 :4.2
引用产品: LLC [LL/2; LLC1] 细胞 , B16 细胞
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HDAC3 inhibitors induce drug resistance by promoting IL-17 A production by T cells (2024-12-30)
期刊:Scientific Reports
DOI:10.1038/s41598-024-83447-8
影响因子 :3.8
引用产品: LLC [LL/2; LLC1] 细胞 , EL4 细胞 , 特级胎牛血清
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Gut microbiome affects the response to immunotherapy in non-small cell lung cancer (2024-04-04)
期刊:Thoracic Cancer
影响因子 :2.9
引用产品: LLC [LL/2; LLC1] 细胞
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The effect and mechanism of IL-37d on neutrophil recruitment in the early stage of tumor metastasis in the lungs (2024-11-29)
期刊:Discover Oncology
DOI:10.1007/s12672-024-01608-7
影响因子 :2.8
引用产品: LLC [LL/2; LLC1] 细胞
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Amplifying T cell-mediated antitumor immune responses in nonsmall cell lung cancer through photodynamic therapy and anti-PD1 (2024-01-17)
期刊:CELL BIOCHEMISTRY AND FUNCTION
DOI:10.1002/cbf.3925
影响因子 :2.8
引用产品: LLC [LL/2; LLC1] 细胞
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Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment (2024-10-23)
期刊:EUROPEAN JOURNAL OF HISTOCHEMISTRY
影响因子 :2.1
引用产品: LLC [LL/2; LLC1] 细胞
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Antihyperlipidemic drug rosuvastatin suppressed tumor progression and potentiated chemosensitivity by downregulating CCNA2 in lung adenocarcinoma (2024-01-30)
期刊:JOURNAL OF CHEMOTHERAPY
DOI:10.1080/1120009X.2024.2308975
影响因子 :1.9
引用产品: LLC [LL/2; LLC1] 细胞 , CMT64 细胞 , A549 [A-549] 细胞 , NCI-H1299 细胞 , WI-38 细胞 , MRC-5 细胞
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Oxyhaemoglobin saturation NIR-IIb imaging for assessing cancer metabolism and predicting the response to immunotherapy (2023-09-11)
期刊:Nature Nanotechnology
DOI:10.1038/s41565-023-01501-4
影响因子 :38.3
引用产品: 4T1 细胞 , EMT6 [EMT-6] 细胞 , Renca [RenCa] 细胞 , LLC [LL/2; LLC1] 细胞 , CT26.WT 细胞 , MFC 细胞
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Liquid Metal Nanoplatform Based Autologous Cancer Vaccines (2023-05-30)
期刊:ACS Nano
影响因子 :17.1
引用产品: LLC [LL/2; LLC1] 细胞
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Generation of whole tumor cell vaccine for on-demand manipulation of immune responses against cancer under near-infrared laser irradiation (2023-07-26)
期刊:Nature Communications
DOI:10.1038/s41467-023-40207-y
影响因子 :16.6
引用产品: 4T1 细胞 , CT26.WT 细胞 , LLC [LL/2; LLC1] 细胞
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Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy (2023-08-22)
期刊:Nature Communications
DOI:10.1038/s41467-023-40814-9
影响因子 :16.6
引用产品: CTLL-2 细胞 , A-375 细胞 , LLC [LL/2; LLC1] 细胞 , RAW 264.7 细胞
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Autologous-cancer-cryoablation-mediated nanovaccine augments systematic immunotherapy (2023-02-21)
期刊:Materials Horizons
影响因子 :13.3
引用产品: LLC [LL/2; LLC1] 细胞
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Targeting the Immunoglobulin IGSF9 Enhances Antitumor T-cell Activity and Sensitivity to Anti–PD-1 Immunotherapy (2023-10-13)
期刊:CANCER RESEARCH
DOI:10.1158/0008-5472.CAN-22-3115
影响因子 :11.2
引用产品: THP-1 细胞 , LLC [LL/2; LLC1] 细胞
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner (2023-02-03)
期刊:Cancer Immunology Research
DOI:10.1158/2326-6066.CIR-22-0439
影响因子 :10.1
引用产品: Jurkat, Clone E6-1 细胞 , RKO 细胞 , CT26.WT 细胞 , B16-F10 细胞 , MC38 细胞 , 4T1 细胞 , LLC [LL/2; LLC1] 细胞 , Hepa 1-6 细胞 , YAC-1 细胞 , 293T [HEK-293T] 细胞 , AAV-293 细胞 , STR鉴定
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Metal-Phenolic network pH-Sensitive Nanoparticle-Enabled Chemo/Chemodynamic therapy for lung cancer (2023-06-08)
期刊:MATERIALS & DESIGN
DOI:10.1016/j.matdes.2023.112072
影响因子 :8.4
引用产品: LLC [LL/2; LLC1] 细胞 , A549 [A-549] 细胞
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CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells (2023-08-31)
期刊:ONCOGENE
DOI:10.1038/s41388-023-02824-1
影响因子 :8.0
引用产品: LLC [LL/2; LLC1] 细胞
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Dual Stimuli-Responsive Micelles for Imaging-Guided Mitochondrion-Targeted Photothermal/Photodynamic/Chemo Combination Therapy-Induced Immunogenic Cell Death (2023-08-01)
期刊:International Journal of Nanomedicine
影响因子 :8.0
引用产品: A549 [A-549] 细胞 , NCI-H1975 细胞 , LLC [LL/2; LLC1] 细胞
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Hypoxia-induced AFAP1L1 regulates pathological neovascularization via the YAP-DLL4-NOTCH axis (2023-09-22)
期刊:Journal of Translational Medicine
DOI:10.1186/s12967-023-04503-x
影响因子 :7.4
引用产品: A549 [A-549] 细胞 , LLC [LL/2; LLC1] 细胞
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Radiation-Induced Bystander Effect on the Genome of Bone Marrow Mesenchymal Stem Cells in Lung Cancer (2023-04-10)
期刊:ANTIOXIDANTS & REDOX SIGNALING
影响因子 :6.6
引用产品: A549 [A-549] 细胞 , NCI-H1299 细胞 , NCI-H446 [H446] 细胞 , LLC [LL/2; LLC1] 细胞
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E74?like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non?small cell lung cancer (2023-07-11)
期刊:INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
影响因子 :5.4
引用产品: LLC [LL/2; LLC1] 细胞
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Yulangsan polysaccharide inhibits epithelial-mesenchymal transition and invasion in NSCLC by attenuating the TGF-β1/ERK signaling pathway (2023-08-15)
期刊:American Journal of Cancer Research
DOI:PMID:37693151
影响因子 :5.3
引用产品: A549 [A-549] 细胞 , LLC [LL/2; LLC1] 细胞
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Study the inhibitory effect and mechanism of the ethanol extract of deziyangxin on LLC cells (2023-07-27)
期刊:Heliyon
DOI:10.1016/j.heliyon.2023.e18712
影响因子 :4.0
引用产品: LLC [LL/2; LLC1] 细胞 , GES-1 细胞
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Prebiotics Modulate Gut Microbiota-mediated T-cell Immunity to Enhance the Inhibitory Effect of Sintilimab in Lewis Lung Adenocarcinoma Model Mice (2023-10-01)
期刊:Anti-Cancer Agents in Medicinal Chemistry
DOI:10.2174/1871520623666230707112244
影响因子 :2.8
引用产品: LLC [LL/2; LLC1] 细胞 , 磷酸盐缓冲液(PBS) 1×
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Veillonella parvula promotes the proliferation of lung adenocarcinoma through the nucleotide oligomerization domain 2/cellular communication network factor 4/nuclear factor kappa B pathway (2023-07-14)
期刊:Discover Oncology
DOI:10.1007/s12672-023-00748-6
影响因子 :2.2
引用产品: LLC [LL/2; LLC1] 细胞 , A549 [A-549] 细胞 , BEAS-2B 细胞
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Sambucus adnata Polysaccharide SPS-1 Inhibits Growth of Transplanted Lung Cancer via Polarizing Tumor Associated Macrophage From M2 into M1 (2023-07-10)
期刊:Natural Product Communications
影响因子 :1.8
引用产品: LLC [LL/2; LLC1] 细胞
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Intelligent triggering of nanomicelles based on a ROS-activated anticancer prodrug and photodynamic therapy (PDT)-synergistic therapy for lung cancers (2022-08-03)
期刊:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI:10.1016/j.ejmech.2022.114622
影响因子 :7.1
引用产品: MCF7 [MCF-7] 细胞 , LLC [LL/2; LLC1] 细胞
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Reassembling of albumin-bound paclitaxel mitigates myelosuppression and improves its antitumoral efficacy via neutrophil-mediated targeting drug delivery (2022-02-21)
期刊:Drug Delivery
DOI:10.1080/10717544.2022.2046892
影响因子 :6.0
引用产品: LLC [LL/2; LLC1] 细胞
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Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene (2022-08-03)
期刊:Frontiers in Oncology
影响因子 :5.7
引用产品: LLC [LL/2; LLC1] 细胞
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Nanomicelle-Microsphere Composite as a Drug Carrier to Improve Lung-Targeting Specificity for Lung Cancer (2022-02-25)
期刊:Pharmaceutics
DOI:10.3390/pharmaceutics14030510
影响因子 :5.4
引用产品: A549 [A-549] 细胞 , LLC [LL/2; LLC1] 细胞
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Melatonin attenuates bone cancer pain via the SIRT1/HMGB1 pathway (2022-09-17)
期刊:NEUROPHARMACOLOGY
DOI:10.1016/j.neuropharm.2022.109254
影响因子 :5.3
引用产品: LLC [LL/2; LLC1] 细胞
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Shashen-Maidong Decoction inhibited cancer growth under intermittent hypoxia conditions by suppressing oxidative stress and inflammation (2022-09-02)
期刊:JOURNAL OF ETHNOPHARMACOLOGY
影响因子 :5.2
引用产品: LLC [LL/2; LLC1] 细胞
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Black phosphorus nanoparticles for dual therapy of non-small cell lung cancer (2022-02-02)
期刊:Journal Of Drug Targeting
DOI:10.1080/1061186X.2022.2032093
影响因子 :5.0
引用产品: LLC [LL/2; LLC1] 细胞 , NCI-H1299 细胞
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Alterations of lung microbiota in patients with non-small cell lung cancer (2022-03-07)
期刊:Bioengineered
DOI:10.1080/21655979.2022.2045843
影响因子 :4.9
引用产品: LLC [LL/2; LLC1] 细胞
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Transplantation of feces from mice with Alzheimers disease promoted lung cancer growth (2022-01-24)
期刊:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI:10.1016/j.bbrc.2022.01.078
影响因子 :3.1
引用产品: LLC [LL/2; LLC1] 细胞
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Luteolin Relieves Lung Cancer-Induced Bone Pain by Inhibiting NLRP3 Inflammasomes and Glial Activation in the Spinal Dorsal Horn in Mice (2021-12-25)
期刊:Phytomedicine
DOI:10.1016/j.phymed.2021.153910
影响因子 :7.9
引用产品: LLC [LL/2; LLC1] 细胞
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Erianin inhibits human lung cancer cell growth via PI3K/Akt/mTOR pathway in vitro and in vivo (2021-03-17)
期刊:Phytotherapy Research
DOI:10.1002/ptr.7154
影响因子 :7.2
引用产品: NCI-H1975 细胞 , LLC [LL/2; LLC1] 细胞 , A549 [A-549] 细胞 , 293A 细胞
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DHA/EPA-Enriched Phosphatidylcholine Suppresses Tumor Growth and Metastasis via Activating Peroxisome Proliferator-Activated Receptor γ in Lewis Lung Cancer Mice (2021-01-06)
期刊:Journal Of Agricultural And Food Chemistry
影响因子 :6.1
引用产品: LLC [LL/2; LLC1] 细胞
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Jolkinolide B inhibits proliferation or migration and promotes apoptosis of MCF-7 or BT-474 breast cancer cells by downregulating the PI3K-Akt pathway (2021-08-28)
期刊:Journal Of Ethnopharmacology
影响因子 :5.4
引用产品: MCF7 [MCF-7] 细胞 , LLC [LL/2; LLC1] 细胞
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Depression promotes lung carcinoma progression by regulating the tumor microenvironment in tumor-bearing models of C57BL/6J mice (2021-05-29)
期刊:Neuroscience Letters
DOI:10.1016/j.neulet.2021.135851
影响因子 :2.5
引用产品: LLC [LL/2; LLC1] 细胞
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Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model (2021-09-27)
期刊:Immunity Inflammation and Disease
DOI:10.1002/iid3.533
影响因子 :2.2
引用产品: LLC [LL/2; LLC1] 细胞
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