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产品概述
| 名称 | YAC-1 (小鼠淋巴瘤细胞) (STR鉴定正确) |
| 别称 | Yac-1; YAC |
| 种属 | 小鼠 |
| 生长特性 | 悬浮细胞 |
| 细胞形态 | 淋巴母细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 3×10^5-5×10^5cells/mL |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞为悬浮细胞，请注意离心收集细胞悬液；请勿直接倒掉细胞培养液。 |
| 背景描述 | YAC-1是一个淋巴瘤细胞，将Moloney白血病病毒(MLV)接种到新生A/Sn小鼠中生成。YAC-1细胞对NK细胞的活动敏感，对于NK细胞活性检测十分有用。 |
| 年龄（性别） | 不详 |
| 组织来源 | Moloney鼠科白血病毒(Mo-MuLV)感染；淋巴瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 淋巴瘤细胞 |
| 生物安全等级 | BSL-2 |
| 倍增时间 | ~20 hours |
| 保藏机构 | ATCC; TIB-160 DSMZ; ACC-96 ECACC; 86022801 |
STR鉴定
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STR位点信息
18-3 18 6-7 12 5-5 16 X-1 26 1-2 17,18 7-1 25.2 8-1 16 1-1 11 19-2 12,13 15-3 22.3 12-1 16 6-4 18 4-2 21.3 3-2 14 2-1 16 13-1 16.2,17.2
11-2 15 17-2 16 -
STR鉴定图
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参考文献
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner (2023-02-03)
作者：Yiru Long:1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ; 2.University of Chinese Academy of Sciences, Beijing, China. ; Runqiu Chen:1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ; 2.Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China. ; Xiaolu Yu:1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ; 2.University of Chinese Academy of Sciences, Beijing, China. ; Yongliang Tong:1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ; 2.University of Chinese Academy of Sciences, Beijing, China. ; Xionghua Peng:1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
期刊：Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner
DOI：10.1158/2326-6066.CIR-22-0439
影响因子 ：10.1
引用产品： Jurkat, Clone E6-1 细胞 , RKO 细胞 , CT26.WT 细胞 , B16-F10 细胞 , MC38 细胞 , 4T1 细胞 , LLC [LL/2; LLC1] 细胞 , Hepa 1-6 细胞 , YAC-1 细胞 , 293T [HEK-293T] 细胞 , AAV-293 细胞 , STR鉴定
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Sirtuin 2 up-regulation suppresses the anti-tumour activity of exhausted natural killer cells in mesenteric lymph nodes in murine colorectal carcinoma (2023-08-07)
作者：Bin Jiang:1.The Department of Gastrointestinal, Hernia, and Abdominal Wall Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China. ; Chao Ke:1.The Department of Gastrointestinal, Hernia, and Abdominal Wall Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China. ; Hongjian Zhou:1.The Department of Gastrointestinal, Hernia, and Abdominal Wall Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China. ; Tian Xia:1.The Department of Gastrointestinal, Hernia, and Abdominal Wall Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China. ; Xingwang Xie:1.The Department of Gastrointestinal, Hernia, and Abdominal Wall Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China. ; Hanbin Xu:1.The Department of Gastrointestinal, Hernia, and Abdominal Wall Surgery, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China. ;
期刊：Sirtuin 2 up-regulation suppresses the anti-tumour activity of exhausted natural killer cells in mesenteric lymph nodes in murine colorectal carcinoma
影响因子 ：3.7
引用产品： YAC-1 细胞
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Sirtuin 6 is a negative regulator of the anti-tumor function of natural killer cells in murine inflammatory colorectal cancer (2023-05-03)
作者：Fei Xiao:1.The Division of Gastrointestinal Surgery, Wuhan Fourth Hospital (Tongji Medical College Affiliated Wuhan Puai Hospital), 473 Hanzheng Street, Qiaokou District, Wuhan, Hubei Province 430033, China. ; Bo Hu:1.The Division of Gastrointestinal Surgery, Wuhan Fourth Hospital (Tongji Medical College Affiliated Wuhan Puai Hospital), 473 Hanzheng Street, Qiaokou District, Wuhan, Hubei Province 430033, China. ; Zhilong Si:1.The Division of Gastrointestinal Surgery, Wuhan Fourth Hospital (Tongji Medical College Affiliated Wuhan Puai Hospital), 473 Hanzheng Street, Qiaokou District, Wuhan, Hubei Province 430033, China. ; Huanbin Yang:1.The Division of Gastrointestinal Surgery, Wuhan Fourth Hospital (Tongji Medical College Affiliated Wuhan Puai Hospital), 473 Hanzheng Street, Qiaokou District, Wuhan, Hubei Province 430033, China. ; Jun Xie:1.The Division of Gastrointestinal Surgery, Wuhan Fourth Hospital (Tongji Medical College Affiliated Wuhan Puai Hospital), 473 Hanzheng Street, Q
期刊：Sirtuin 6 is a negative regulator of the anti-tumor function of natural killer cells in murine inflammatory colorectal cancer
DOI：10.1016/j.molimm.2023.04.011
影响因子 ：3.6
引用产品： YAC-1 细胞
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Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression (2009-01-20)
作者：Sheng Xu:1.Research Centre for Regenerative Medicine, Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration, Guangxi Medical University, Nanning, Guangxi 530021, PR China. ; Huanhuan Tan:1.State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China. ; Qianqian Yang:1.State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China. ; Riyuan Wang:1.State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology, Research Center for Novel Silk Materials, Biological Science Research Center, Southwest University, Chongqing 400715, PR China. ; Chi Tian:1.State Key Laboratory of Silkworm Genome Biology, Chongqing Engineering and Technology
期刊：Fabrication of a Silk Sericin Hydrogel System Delivering Human Lactoferrin Using Genetically Engineered Silk with Improved Bioavailability to Alleviate Chemotherapy-Induced Immunosuppression
影响因子 ：10.4
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Down-regulation of PR/SET domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma (2010-01-20)
作者：Jiantao Han:1.The Department of Hepatobiliary and Pancreatic Surgery, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. ; Chao Ke:1.The Department of Gastrointestinal, Hernia and Abdominal Wall Surgery, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. ; Bin Jiang:1.The Department of Gastrointestinal, Hernia and Abdominal Wall Surgery, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. ; Hongjian Zhou:1.The Department of Gastrointestinal, Hernia and Abdominal Wall Surgery, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. ; Hanbin Xu:1.The Department of Gastrointestinal, Hernia and Abdominal Wall Surgery, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. ; Xingwang Xie:1.The Department of Hepatobiliary and Pancreatic Surgery, Tongren Hospital of Wuhan University, Wuhan, Hubei Province, China. ;
期刊：Down-regulation of PR/SET domain 10 underlies natural killer cell dysfunction in hepatocellular carcinoma
影响因子 ：4.6
引用产品： YAC-1 细胞
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