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产品概述
| 名称 | Hepa 1-6 (小鼠肝癌细胞) (STR鉴定正确) |
| 别称 | HEPA 1-6; Hepa1-6 |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | Hepa 1-6细胞是C57/L小鼠中产生的BW7756小鼠肝癌的衍生株。 |
| 年龄（性别） | 雌性 |
| 组织来源 | 肝；肝癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肝癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~24-30 hours |
| 基因表达情况 | albumin, alpha fetoprotein (AFP, alpha-fetoprotein); albumin; alpha 1 antitrypsin (alpha-1-antitrypsin); amylase |
| 保藏机构 | ATCC; CRL-1830 BCRC; 60051 DSMZ; ACC-175 ECACC; 92110305 |
STR鉴定
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STR位点信息
18-3 16,17 6-7 15 5-5 17 X-1 25 1-2 13 7-1 25.2 8-1 15 1-1 14,15,16 19-2 10,11 15-3 17,18,19 12-1 17 6-4 18,19 4-2 18.3,19.3 3-2 10 2-1 14 13-1 17.2
11-2 16 17-2 14 -
STR鉴定图
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参考文献
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LncRNA CRNDE Drives the Progression of Hepatocellular Carcinoma by inducing the Immunosuppressive Niche (2024-01-01)
期刊：International Journal of Biological Sciences
影响因子 ：9.2
引用产品： Hepa 1-6 细胞
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Decoding the complexity of on-target integration: characterizing DNA insertions at the CRISPR-Cas9 targeted locus using nanopore sequencing (2024-02-17)
期刊：BMC GENOMICS
DOI：10.1186/s12864-024-10050-6
影响因子 ：4.4
引用产品： Hepa 1-6 细胞
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner (2023-02-03)
期刊：Cancer Immunology Research
DOI：10.1158/2326-6066.CIR-22-0439
影响因子 ：10.1
引用产品： Jurkat, Clone E6-1 细胞 , RKO 细胞 , CT26.WT 细胞 , B16-F10 细胞 , MC38 细胞 , 4T1 细胞 , LLC [LL/2; LLC1] 细胞 , Hepa 1-6 细胞 , YAC-1 细胞 , 293T [HEK-293T] 细胞 , AAV-293 细胞 , STR鉴定
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Conjugating 4β-NH-(5-Aminoindazole)-podophyllotoxin and Galectin-1-Targeted Aptamer for Synergistic Chemo-Immunotherapy of Hepatocellular Carcinoma (2023-05-04)
期刊：Advanced Healthcare Materials
影响因子 ：10.0
引用产品： Hep G2 细胞 , HuH-7 细胞 , PLC/PRF/5 细胞 , SNU387 细胞 , MCF7 [MCF-7] 细胞 , Hepa 1-6 细胞
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The spatial and single-cell analysis reveals remodeled immune microenvironment induced by synthetic oncolytic adenovirus treatment (2023-11-24)
期刊：CANCER LETTERS
DOI：10.1016/j.canlet.2023.216485
影响因子 ：9.7
引用产品： Hepa 1-6 细胞
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Sono-Immunotherapy Mediated Controllable Composite Nano Fluorescent Probes Reprogram the Immune Microenvironment of Hepatocellular Carcinoma (2023-10-25)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
引用产品： Hepa 1-6 细胞
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β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer (2023-01-26)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-03914-0
影响因子 ：7.4
引用产品： 马血清 , HuH-7 细胞 , Hepa 1-6 细胞 , SNU-182 细胞
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Tumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpoint (2023-03-17)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04060-3
影响因子 ：7.4
引用产品： Hepa 1-6 细胞
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Protein-Gold Nanoclusters Loaded with Ferrous Ions for Inducing Ferroptosis of Hepatoma Cells (2023-04-05)
期刊：Advanced Materials Technologies
影响因子 ：6.8
引用产品： Hepa 1-6 细胞
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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis (2023-08-23)
期刊：CHINESE MEDICAL JOURNAL
DOI：10.1097/CM9.0000000000002816
影响因子 ：6.1
引用产品： 马血清 , Hepa 1-6 细胞 , HuH-7 细胞
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Low Pi stress enhances the sensitivity of hepatocellular carcinoma to sorafenib (2023-05-16)
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：5.8
引用产品： Hepa 1-6 细胞
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Hepatic Symbiotic Bacterium L. reuteri FLRE5K1 Inhibits the Development and Progression of Hepatocellular Carcinoma via Activating the IFN-γ/CXCL10/CXCR3 Pathway (2023-06-08)
期刊：Probiotics and Antimicrobial Proteins
DOI：10.1007/s12602-023-10098-y
影响因子 ：4.9
引用产品： Hepa 1-6 细胞
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A Comparative Study of Antitumor Immunity Induced by Radiofrequency Microwave and Cryoablation in Hepatocellular Carcinoma (2023-10-27)
期刊：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
DOI：10.1007/s12010-023-04760-y
影响因子 ：3.0
引用产品： Hepa 1-6 细胞 , Hep G2 细胞
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Visualization system based on hierarchical targeting for diagnosis and treatment of hepatocellular carcinoma (2022-08-22)
期刊：Materials Today Bio
DOI：10.1016/j.mtbio.2022.100398
影响因子 ：10.8
引用产品： HuH-7 细胞 , Hepa 1-6 细胞
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Improved anti-hepatocellular carcinoma effect by enhanced Co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles (2007-02-20)
期刊：Materials Today Bio
DOI：10.1016/j.mtbio.2022.100350
影响因子 ：8.2
引用产品： Hepa 1-6 细胞 , H22 细胞
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Parathyroid hormone alleviates non-alcoholic liver steatosis via activating the hepatic cAMP/PKA/CREB pathway. (2022-08-17)
期刊：Frontiers in Endocrinology
影响因子 ：6.1
引用产品： Hepa 1-6 细胞
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TroTNFSF6, a tumor necrosis factor ligand superfamily member, promotes antibacterial immune response of golden pompano, Trachinotus ovatus (2022-12-11)
期刊：FISH & SHELLFISH IMMUNOLOGY
影响因子 ：4.6
引用产品： Hepa 1-6 细胞
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Microwave ablation combined with anti-PD-1 therapy enhances systemic antitumor immunity in a multitumor murine model of Hepa1-6 (2002-02-20)
期刊：International Journal Of Hyperthermia
DOI：10.1080/02656736.2022.2032406
影响因子 ：3.1
引用产品： Hepa 1-6 细胞 , DMEM高糖 培养基 , 特级胎牛血清
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Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling (2010-01-20)
期刊：International Journal of Biological Sciences
影响因子 ：9.2
引用产品： Hepa 1-6 细胞
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Cantharidin-loaded biomimetic MOF nanoparticle cascade to enhance the Fenton reaction based on amplified photothermal therapy (2010-01-20)
期刊：Biomaterials Science
影响因子 ：7.6
引用产品： Hep G2 细胞 , RAW 264.7 细胞 , Hepa 1-6 细胞 , H22 细胞
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Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1 (2002-01-20)
期刊：Journal Of Cellular Physiology
影响因子 ：5.6
引用产品： Hepa 1-6 细胞
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Insulin-like growth factor binding protein 3 gene of golden pompano (TroIGFBP3) promotes antimicrobial immune defense (2004-00-20)
期刊：Fish & Shellfish Immunology
影响因子 ：4.7
引用产品： Hepa 1-6 细胞
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Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells (2010-09-20)
期刊：Gastroenterology
DOI：10.1053/j.gastro.2019.10.025
影响因子 ：29.4
引用产品： H22 细胞 , Hepa 1-6 细胞
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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy (2010-09-20)
期刊：Nature Communications
DOI：10.1038/s41467-019-12794-2
影响因子 ：16.6
引用产品： Hepa 1-6 细胞
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Mitochondrial respiratory chain dysfunction mediated by ROS is a primary point of fluoride-induced damage in Hepa1-6 cells (2010-09-20)
期刊：Environmental Pollution
DOI：10.1016/j.envpol.2019.113359
影响因子 ：8.9
引用产品： Hepa 1-6 细胞
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