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产品概述
| 名称 | CAL 27 (人舌鳞癌细胞) (STR鉴定正确) |
| 别称 | Cal-27; CAL 27; Cal 27; CAL27; Cal27; Centre Antoine Lacassagne-27 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | CAL 27细胞是由J·Gioanni于1982年建系，源自一位56岁白人男性的舌头中倍的病变部位；CAL 27细胞角蛋白强阳性。 |
| 年龄（性别） | 男性；56岁 |
| 组织来源 | 舌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 舌鳞癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~20-45 hours |
| 致瘤性 | Yes, solid tumors developed within 6 weeks in nude mice inoculated with 2×10^6 cells subcutaneously. |
| 保藏机构 | ATCC; CRL-2095 DSMZ; ACC-446 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 23,24 D3S1358 16 D5S818 11,12 D7S820 10 D8S1179 13,15 D13S317 10,11 D16S539 11,12 D18S51 13 D19S433 14,15.2 D21S11 28,29 FGA 25 PentaD 9,10 PentaE 7 TH01 6,9.3 TPOX 8 vWA 14,17 D6S1043 12 D12S391 18.3,20 D2S441 10,11.3 -
STR鉴定图
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参考文献
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A label-free fluorescence aptasensor for salivary exosomes based on a nano-micro dual-scale signal amplification strategy (2025-01-27)
期刊：TALANTA
DOI：10.1016/j.talanta.2025.127638
影响因子 ：5.6
引用产品： CAL 27 细胞
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Knockdown of HOXD13 in Oral Squamous Cell Carcinoma Inhibited its Proliferation, Migration, and Influenced Fatty Acid Metabolism (2025-01-01)
期刊：Journal of Cancer
影响因子 ：3.3
引用产品： SCC-9 [SCC 9; SCC9] 细胞 , SCC-25 [SCC 25; SCC25] 细胞 , CAL 27 细胞
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A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response (2025-01-27)
期刊：Discover Oncology
DOI：10.1007/s12672-025-01803-0
影响因子 ：2.8
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Strong, Tough, and Biocompatible Poly(vinyl alcohol)–Poly(vinylpyrrolidone) Multiscale Network Hydrogels Reinforced by Aramid Nanofibers (2024-04-23)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： CAL 27 细胞
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High-Performance Photodynamic Therapy of Tongue Squamous Cell Carcinoma with Multifunctional Nano-Verteporfin (2024-03-13)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
引用产品： CAL 27 细胞
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Combined miR-181a-5p and Ag Nanoparticles are Effective Against Oral Cancer in a Mouse Model (2024-09-06)
期刊：International Journal of Nanomedicine
影响因子 ：6.6
引用产品： CHO 细胞 , CAL 27 细胞 , HT22 细胞 , 293T [HEK-293T] 细胞 , SCC-9 [SCC 9; SCC9] 细胞 , SH-SY5Y [SHSY-5Y] 细胞
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Tumor Necrosis Factor α–Induced Protein 8–Like Protein 1 Binds to Protein Arginine Methyltransferase 1 To Suppress the Methylation of Signal Transducer and Activator of Transcription 3 and Cell Growth in Oral Squamous Cell Carcinoma (2024-03-02)
期刊：AMERICAN JOURNAL OF PATHOLOGY
DOI：10.1016/j.ajpath.2024.02.010
影响因子 ：6.0
引用产品： SCC-25 [SCC 25; SCC25] 细胞 , CAL 27 细胞 , HOK 细胞
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Multifunctional nanoparticles for enhanced sonodynamic–chemodynamic immunotherapy with glutathione depletion (2024-01-25)
期刊：Nanomedicine
影响因子 ：4.7
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RUVBL1 accelerates tongue squamous cell carcinoma by mediating CRaf/MEK/ERK pathway. (2024-03-06)
期刊：iScience
DOI：10.1016/j.isci.2024.109434
影响因子 ：4.6
引用产品： CAL 27 细胞
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Osteoblasts are induced into cancer-associated osteoblasts to promote tumor progression in head and neck squamous cell carcinoma (2024-07-27)
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2024.167439
影响因子 ：4.2
引用产品： RAW 264.7 细胞 , CAL 27 细胞 , MC3T3-E1 Subclone 14 细胞
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USP14 promotes the cancer stem-like cell properties of OSCC via promoting SOX2 deubiquitination (2024-02-20)
期刊：ORAL DISEASES
影响因子 ：3.8
引用产品： SCC-25 [SCC 25; SCC25] 细胞 , CAL 27 细胞
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Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1 (2024-01-22)
期刊：BMC CANCER
DOI：10.1186/s12885-024-11855-0
影响因子 ：3.8
引用产品： SCC-25 [SCC 25; SCC25] 细胞 , CAL 27 细胞
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CLSPN actives Wnt/β-catenin signaling to facilitate glycolysis and cell proliferation in oral squamous cell carcinoma (2024-01-17)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2024.113935
影响因子 ：3.7
引用产品： SCC-9 [SCC 9; SCC9] 细胞 , TSCCa 细胞 , CAL 27 细胞 , DMEM/F12完全培养基 (含10%FBS）
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Dihydroartemisinin inhibits HNSCC invasion and migration by controlling miR-195-5p expression (2024-06-06)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e32522
影响因子 ：3.4
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Inhibin A contributes to the tumorigenesis of oral squamous cell carcinoma by KIAA1429-mediated m6A modification (2024-03-26)
期刊：JOURNAL OF ORAL PATHOLOGY & MEDICINE
影响因子 ：3.3
引用产品： CAL 27 细胞 , SCC-9 [SCC 9; SCC9] 细胞
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IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathway (2024-01-25)
期刊：World Journal of Surgical Oncology
DOI：10.1186/s12957-023-03274-5
影响因子 ：3.2
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Isocorydine Exerts Anticancer Activity by Disrupting the Energy Metabolism and Filamentous Actin Structures of Oral Squamous Carcinoma Cells (2024-01-09)
期刊：CURRENT ISSUES IN MOLECULAR BIOLOGY
影响因子 ：3.1
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Synergistic inhibition of proliferation and induction of apoptosis in oral tongue squamous cell carcinoma by mebendazole and paclitaxel via PI3K/AKT pathway mitigation (2024-11-30)
期刊：NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
DOI：10.1007/s00210-024-03670-y
影响因子 ：3.1
引用产品： UM-SCC-1 细胞 , 磷酸盐缓冲液（PBS） 1× , CAL 27 细胞 , DMEM高糖 培养基
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Near-infrared imaging of head and neck squamous cell carcinoma using indocyanine green that targets the αvβ6 peptide (2024-04-17)
期刊：JOURNAL OF BIOMEDICAL OPTICS
影响因子 ：3.0
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High expression of serine protease inhibitor kazal type 1 predicts poor prognosis and promotes the progression and invasion of oral tongue squamous cell carcinoma (2024-05-17)
期刊：ARCHIVES OF ORAL BIOLOGY
DOI：10.1016/j.archoralbio.2024.106003
影响因子 ：3.0
引用产品： CAL 27 细胞
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High expression of ACTL6A leads to poor prognosis of oral squamous cell carcinoma patients through promoting malignant progression (2024-03-24)
期刊：HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
影响因子 ：2.9
引用产品： CAL 27 细胞 , DMEM高糖 培养基
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Correlation of DNA methylation of DNMT3A and TET2 with oral squamous cell carcinoma (2024-01-22)
期刊：Discover Oncology
DOI：10.1007/s12672-024-00866-9
影响因子 ：2.2
引用产品： CAL 27 细胞
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CAFs-derived TIAM1 Promotes OSCC Cell Growth and Metastasis by Regulating ZEB2 (2024-09-10)
期刊：CELL BIOCHEMISTRY AND BIOPHYSICS
DOI：10.1007/s12013-024-01505-4
影响因子 ：1.8
引用产品： SCC-25 [SCC 25; SCC25] 细胞 , DMEM高糖 培养基 , CAL 27 细胞 , SCC-25 [SCC 25; SCC25]细胞专用培养基
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Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1 (2023-08-08)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-06024-3
影响因子 ：9.0
引用产品： CAL 27 细胞 , SCC-9 [SCC 9; SCC9]细胞专用培养基
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Nano-Photosensitizer Directed Targeted Phototherapy Effective Against Oral Cancer in Animal Model (2023-10-31)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
引用产品： CAL 27 细胞
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Pan-cancer analysis of PLAU indicates its potential prognostic value and correlation with neutrophil infiltration in BLCA (2023-11-22)
期刊：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI：10.1016/j.bbadis.2023.166965
影响因子 ：6.2
引用产品： MCF7 [MCF-7] 细胞 , Caco-2 细胞 , SW480 [SW-480] 细胞 , CAL 27 细胞 , KHM-5M 细胞 , SV-HUC-1 细胞 , 5637 细胞 , UM-UC-3 细胞 , EJ-1 细胞 , T24 [T-24] 细胞 , TCCSUP 细胞
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DDX5 Functions as a Tumor Suppressor in Tongue Cancer (2023-12-18)
期刊：Cancers
影响因子 ：5.2
引用产品： SCC-9 [SCC 9; SCC9] 细胞 , CAL 27 细胞
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SENP1 inhibits ferroptosis and promotes head and neck squamous cell carcinoma by regulating ACSL4 protein stability via SUMO1 (2023-12-28)
期刊：ONCOLOGY REPORTS
影响因子 ：4.2
引用产品： CAL 27 细胞 , HOK 细胞
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Homeobox-D 1 and FTO form a transcriptional–epigenetic feedback loop to promote head and neck cancer proliferation (2023-09-01)
期刊：CELL BIOLOGY INTERNATIONAL
影响因子 ：3.9
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Anticancer role of lidocaine in oral squamous cell carcinoma through IGF2BP2-mediated CAV1 stability (2023-12-09)
期刊：ORAL DISEASES
影响因子 ：3.8
引用产品： CAL 27 细胞 , SCC-25 [SCC 25; SCC25] 细胞 , 特级胎牛血清
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Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro (2023-02-17)
期刊：BMC CANCER
DOI：10.1186/s12885-023-10600-3
影响因子 ：3.8
引用产品： CAL 27 细胞 , SCC-25 [SCC 25; SCC25] 细胞
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N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4 (2023-09-12)
期刊：BIOLOGICAL CHEMISTRY
影响因子 ：3.7
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Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma (2023-02-03)
期刊：Epigenetics
DOI：10.1080/15592294.2023.2175168
影响因子 ：3.7
引用产品： CAL 27 细胞
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MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy: MFAP2 and autophagy-induced OSCC progression (2023-08-17)
期刊：ACTA BIOCHIMICA ET BIOPHYSICA SINICA
影响因子 ：3.7
引用产品： SCC15 细胞 , SCC-25 [SCC 25; SCC25] 细胞 , CAL 27 细胞 , DMEM高糖 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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Pan-cancer analysis reveals the pro-oncogenic role of N6-methyladenosine (m6A)-regulated NTMT1 in head and neck squamous cell carcinoma (2023-11-28)
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.6
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ACTN1 interacts with ITGA5 to promote cell proliferation, invasion and epithelial-mesenchymal transformation in head and neck squamous cell carcinoma (2023-02-01)
期刊：Iranian Journal of Basic Medical Sciences
DOI：10.22038/IJBMS.2022.67056.14703
影响因子 ：2.2
引用产品： 人口腔上皮细胞 , CAL 27 细胞 , SCC-9 [SCC 9; SCC9] 细胞
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Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway (2022-05-05)
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02376-4
影响因子 ：11.3
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Oral Cancer Stem Cell-Derived Small Extracellular Vesicles Promote M2 Macrophage Polarization and Suppress CD4+ T-Cell Activity by Transferring UCA1 and Targeting LAMC2 (2022-11-28)
期刊：Stem Cells International
影响因子 ：5.1
引用产品： CAL 27 细胞 , 293T [HEK-293T] 细胞 , DMEM高糖 (含双抗) 培养基 , THP-1 细胞 , RPMI-1640完全培养基 (含10%FBS）
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Osmanthus-Loaded PVP/PVA Hydrogel Inhibits the Proliferation and Migration of Oral Squamous Cell Carcinoma Cells CAL-27 (2022-12-09)
期刊：Polymers
影响因子 ：5.0
引用产品： CAL 27 细胞
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Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR-145-5p/lysine demethylase 2A (KDM2A) axis in oral squamous cell carcinoma (2022-10-21)
期刊：HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
影响因子 ：3.8
引用产品： HOK 细胞 , SCC-9 [SCC 9; SCC9] 细胞 , SCC-25 [SCC 25; SCC25] 细胞 , CAL 27 细胞 , HSC-2 细胞
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Silencing of circ_OSBPL10 affects the functional behaviors of oral squamous cell carcinoma cells by the miR-299-3p/CDK6 axis (2022-01-31)
期刊：Archives Of Oral Biology
DOI：10.1016/j.archoralbio.2022.105363
影响因子 ：2.6
引用产品： CAL 27 细胞 , SCC-9 [SCC 9; SCC9] 细胞
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Identification and in vitro validation of prognostic lncRNA signature in head and neck squamous cell carcinoma (2021-10-15)
期刊：Bioengineered
DOI：10.1080/21655979.2021.1995577
影响因子 ：4.9
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Overexpression of circCDR1as drives oral squamous cell carcinoma progression (2021-11-24)
期刊：Oral Diseases
影响因子 ：4.1
引用产品： CAL 27 细胞 , SCC-9 [SCC 9; SCC9] 细胞 , 293T [HEK-293T] 细胞 , DMEM高糖 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells (2021-10-07)
期刊：Bmc Cancer
DOI：10.1186/s12885-021-08779-4
影响因子 ：3.8
引用产品： SCC-25 [SCC 25; SCC25] 细胞 , CAL 27 细胞
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Engineered red blood cell membrane for sensitive and precise electrochemical detection of salivary exosomes (2021-12-16)
期刊：Analytical Methods
影响因子 ：3.1
引用产品： CAL 27 细胞
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Curcumin Has Anti-Proliferative and Pro-Apoptotic Effects on Tongue Cancer in vitro: A Study with Bioinformatics Analysis and in vitro Experiments (2020-02-04)
期刊：Drug Design Development and Therapy
影响因子 ：4.3
引用产品： CAL 27 细胞
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Downregulation of lncRNA HCG11 promotes cell proliferation of oral squamous cell carcinoma through sponging miR‐455‐5p (2020-11-05)
期刊：Journal Of Gene Medicine
DOI：10.1002/jgm.3293
影响因子 ：3.5
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BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma (2019-10-07)
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2019.105921
影响因子 ：5.6
引用产品： CAL 27 细胞
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