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产品概述
名称 | H22 (小鼠肝癌细胞) (STR鉴定正确) |
别称 | Hepatoma-22; Hepatoma 22 |
种属 | 小鼠 |
生长特性 | 悬浮细胞 |
细胞形态 | 淋巴母细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 3×10^5-5×10^5cells/mL |
推荐换液频率 | 2-3次/周 |
注意事项 | H22细胞是小鼠腹水瘤细胞,体外培养传代4-5代左右,细胞活力会将低,状态会变差,可通过腹水培养恢复细胞活力。该细胞为悬浮细胞,请注意离心收集细胞悬液;请勿直接倒掉细胞培养液。 |
背景描述 | H22细胞是分离自小鼠腹水,由大连医科学院建立。 |
年龄(性别) | 不详 |
组织来源 | 肝;肝癌 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肝胆癌细胞 |
STR鉴定
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STR位点信息
18-3 11,17 6-7 13 5-5 14 X-1 25 1-2 18,19 7-1 24.2 8-1 17,18 1-1 15,16 19-2 13 15-3 19.3,20.3,25.3 12-1 17 6-4 15.3,16.3 4-2 19.3,20.3 3-2 13,14 2-1 9 13-1 16.2
11-2 16 17-2 13,15 -
STR鉴定图
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参考文献
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Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy (2025-01-06)
期刊:Frontiers in Pharmacology
DOI:10.3389/fphar.2024.1503490
影响因子 :4.4
引用产品: 丙酮酸钠溶液(100 mM),100× , H22 细胞 , HuH-7 细胞
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Preparation of oat galactolipid and anti-liver cancer effects of oat galactolipid–modified curcumin-loaded liver targeting vesicle (2025-01-08)
期刊:Frontiers in Pharmacology
DOI:10.3389/fphar.2024.1511666
影响因子 :4.4
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Mitochondrial dysfunction-driven AMPK-p53 axis activation underpins the anti-hepatocellular carcinoma effects of sulfane sulfur (2025-01-29)
期刊:Scientific Reports
DOI:10.1038/s41598-024-83530-0
影响因子 :3.8
引用产品: H22 细胞
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Intracellular Magnetic Hyperthermia Sensitizes Sorafenib to Orthotopic Hepatocellular Carcinoma Via Amplified Ferroptosis (2024-10-21)
期刊:ACS Nano
影响因子 :15.8
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Rhein-based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization (2024-04-15)
期刊:Aggregate
DOI:10.1002/agt2.552
影响因子 :13.9
引用产品: H22 细胞
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Natural diterpene carrier-free hydrogel enhances antigen presentation and intensifies T cell activation for tumor immunotherapy (2024-10-19)
期刊:CHEMICAL ENGINEERING JOURNAL
影响因子 :13.3
引用产品: H22 细胞
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Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma (2024-02-02)
期刊:MOLECULAR THERAPY
DOI:10.1016/j.ymthe.2024.01.032
影响因子 :12.4
引用产品: H22 细胞
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MATR3 Promotes Liver Cancer Progression by Suppressing DHX58–Mediated Type I Interferon Response (2024-09-12)
期刊:CANCER LETTERS
DOI:10.1016/j.canlet.2024.217231
影响因子 :9.1
引用产品: Hep G2 细胞 , H22 细胞 , 293T [HEK-293T] 细胞 , Hepa 1-6 细胞
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The combination of Brassica rapa L. polysaccharides and cisplatin enhances the anti liver cancer effect and improves intestinal microbiota and metabolic disorders (2024-03-07)
期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI:10.1016/j.ijbiomac.2024.130706
影响因子 :8.2
引用产品: H22 细胞
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Propylene glycol alginate sodium sulfate suppressed lung metastasis by blocking P-selectin to recruit CD4 regulatory T cells (2024-08-22)
期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI:10.1016/j.ijbiomac.2024.134976
影响因子 :7.7
引用产品: H22 细胞
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B cell lymphoma 6 promotes hepatocellular carcinoma progression by inhibiting tumor infiltrating CD4+T cell cytotoxicity through ESM1 (2024-07-01)
期刊:npj Precision Oncology
DOI:10.1038/s41698-024-00625-7
影响因子 :6.8
引用产品: Hepa 1-6 细胞 , H22 细胞 , Hep53.4 细胞 , Hep 3B2.1-7 细胞
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A pH-Responsive Drug-Delivery System Based on Apatinib-Loaded Metal-Organic Frameworks for Ferroptosis-Targeted Synergistic Anti-Tumor Therapy (2024-09-04)
期刊:International Journal of Nanomedicine
影响因子 :6.6
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Glycyrrhizic Acid-Based Liposome for Tumor-Targeted Delivery of Cantharidin (2024-01-02)
期刊:ACS Applied Nano Materials
影响因子 :5.9
引用产品: H22 细胞
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Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity (2024-01-28)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2024.111553
影响因子 :5.6
引用产品: H22 细胞
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Pathogenic Th17 cell-mediated liver fibrosis contributes to resistance to PD-L1 antibody immunotherapy in hepatocellular carcinoma (2024-02-13)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2024.111601
影响因子 :5.6
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Dietary supplementation of α-linolenic acid-rich flaxseed oil enhances anti-PD-1 protection against orthotopic hepatocellular carcinoma by reshaping gut homeostasis and improving anti-tumor immunity via gut-liver axis in mice (2024-04-01)
期刊:Journal of Functional Foods
影响因子 :5.6
引用产品: H22 细胞
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Co-delivery of SN38 and MEF2D-siRNA via tLyp-1-modified liposomes reverses PD-L1 expression induced by STING activation in hepatocellular carcinoma (2024-10-13)
期刊:COLLOIDS AND SURFACES B-BIOINTERFACES
DOI:10.1016/j.colsurfb.2024.114318
影响因子 :5.4
引用产品: RAW 264.7 细胞 , H22 细胞 , Hepa 1-6 细胞
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Dual Targeted Nanoparticles Encapsulating Cantharidin for Treatment of Hepatocellular Carcinoma and Lymphatic Metastasis (2024-08-29)
期刊:ACS Applied Nano Materials
影响因子 :5.3
引用产品: H22 细胞
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Investigation on the mechanisms of scorpion venom in hepatocellular carcinoma model mice via untargeted metabolomics profiling (2024-07-02)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2024.112578
影响因子 :4.8
引用产品: H22 细胞 , 青霉素-链霉素溶液(双抗),100×
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Oxymatrine Inhibits PD-L1 by Downregulating IFN-γ to Promote Ferroptosis and Enhance Anti-PD-L1 Efficacy in Liver Cancer (2024-12-06)
期刊:Journal of Hepatocellular Carcinoma
影响因子 :4.2
引用产品: Hep G2 细胞 , MHCC97-L 细胞 , H22 细胞 , DMEM高糖 培养基 , RPMI-1640 培养基 , 特级胎牛血清
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CD36-mediated accumulation of MDSCs exerts abscopal immunosuppressive responses in hepatocellular carcinoma after insufficient microwave ablation (2024-09-02)
期刊:BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
DOI:10.1016/j.bbadis.2024.167493
影响因子 :4.2
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Green Synthesis of Gold Nanoparticles from Polygahatous Polysaccharides and Their Anticancer Effect on Hepatic Carcinoma through Immunoregulation (2024-05-02)
期刊:ACS Omega
影响因子 :4.1
引用产品: DMEM高糖完全培养基(含10% FBS) , H22 细胞
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Paeoniflorin increases the anti-tumor efficacy of sorafenib in tumor-bearing mice with liver cancer via suppressing the NF-κb/PD-l1 axis (2024-01-13)
期刊:Heliyon
DOI:10.1016/j.heliyon.2024.e24461
影响因子 :4.0
引用产品: H22 细胞
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DSN1 Interaction With Centromere-Associated Proteins Promotes Chromosomal Instability in Hepatocellular Carcinoma (2024-11-19)
期刊:MOLECULAR CARCINOGENESIS
DOI:10.1002/mc.23845
影响因子 :3.0
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Yangzheng mixture reversed EMT against hepatocellular carcinoma metastasis via NF-κB/NLRP3/β-catenin pathway (2024-09-03)
期刊:TOXICON
DOI:10.1016/j.toxicon.2024.108090
影响因子 :2.6
引用产品: H22 细胞
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Protocol for screening potential targets for the treatment of hepatocellular carcinoma based on H22 tumor-bearing mouse model (2024-10-17)
期刊:STAR Protocols
DOI:10.1016/j.xpro.2024.103193
影响因子 :1.3
引用产品: H22 细胞
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Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions (2023-04-17)
期刊:Journal of Advanced Research
DOI:10.1016/j.jare.2023.04.008
影响因子 :10.7
引用产品: H22 细胞
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pH-triggered dynamic erosive small molecule chlorambucil nano-prodrugs mediate robust oral chemotherapy (2023-07-25)
期刊:Asian Journal of Pharmaceutical Sciences
DOI:10.1016/j.ajps.2023.100832
影响因子 :10.2
引用产品: Hep G2 细胞 , H22 细胞 , MCF7 [MCF-7] 细胞 , K-562 [K562] 细胞 , A549 [A-549] 细胞
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Nanoparticles prepared by polysaccharides extracted from Biyang floral mushroom loaded with resveratrol: Characterization, bioactivity and release behavior under in vitro digestion (2023-06-12)
期刊:FOOD CHEMISTRY
DOI:10.1016/j.foodchem.2023.136612
影响因子 :8.8
引用产品: H22 细胞
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Huaier improves the efficacy of anti-PD-L1 Ab in the treatment of hepatocellular carcinoma by regulating tumor immune microenvironment (2023-11-04)
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2023.155189
影响因子 :7.9
引用产品: H22 细胞
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Astaxanthin slows down skeletal muscle atrophy in H22 tumor-bearing mice during sorafenib treatment by modulating the gut microbiota (2023-12-20)
期刊:Food & Function
影响因子 :6.1
引用产品: H22 细胞
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Dietary supplementation with astaxanthin enhances anti-tumor immune response and aids the enhancement of molecularly targeted therapy for hepatocellular carcinoma (2023-08-21)
期刊:Food & Function
影响因子 :6.1
引用产品: H22 细胞
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Antitumor Activity of Carboxymethyl Pachymaran with Different Molecular Weights Based on Immunomodulatory and Gut Microbiota (2023-10-25)
期刊:Nutrients
影响因子 :5.9
引用产品: H22 细胞
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Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma (2023-03-07)
期刊:Cancer Nanotechnology
DOI:10.1186/s12645-023-00166-x
影响因子 :5.7
引用产品: H22 细胞
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Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma (2023-01-11)
期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 :5.6
引用产品: H22 细胞
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Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence (2023-09-27)
期刊:Drug Delivery and Translational Research
DOI:10.1007/s13346-023-01433-5
影响因子 :5.4
引用产品: H22 细胞
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Astaxanthin Supplementation Assists Sorafenib in Slowing Skeletal Muscle Atrophy in H22 Tumor-Bearing Mice via Reversing Abnormal Glucose Metabolism (2023-05-13)
期刊:MOLECULAR NUTRITION & FOOD RESEARCH
影响因子 :5.2
引用产品: H22 细胞
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Astaxanthin Augmented the Anti-Hepatocellular Carcinoma Efficacy of Sorafenib Through the Inhibition of the JAK2/STAT3 Signaling Pathway and Mitigation of Hypoxia within the Tumor Microenvironment (2023-12-07)
期刊:MOLECULAR NUTRITION & FOOD RESEARCH
影响因子 :5.2
引用产品: H22 细胞 , Hepa 1-6 细胞 , BEL-7402 细胞 , 人脐静脉内皮细胞 , HuH-7 细胞
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Comparative transcriptome and proteome analysis explores the antitumor key regulators of ergosterone in H22 tumor-bearing mice (2023-06-07)
期刊:EUROPEAN JOURNAL OF PHARMACOLOGY
DOI:10.1016/j.ejphar.2023.175831
影响因子 :5.0
引用产品: H22 细胞
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Comparative study on the anti-tumor effect of steroids derived from different organisms in H22 tumor-bearing mice and analysis of their mechanisms (2023-12-13)
期刊:EUROPEAN JOURNAL OF PHARMACOLOGY
DOI:10.1016/j.ejphar.2023.176269
影响因子 :5.0
引用产品: H22 细胞
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CDK1-SRC Interaction-Dependent Transcriptional Activation of HSP90AB1 Promotes Antitumor Immunity in Hepatocellular Carcinoma (2023-11-10)
期刊:JOURNAL OF PROTEOME RESEARCH
DOI:10.1021/acs.jproteome.3c00379
影响因子 :4.4
引用产品: HuH-7 细胞 , H22 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗),100× , DMEM高糖 培养基
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Ajmalicine induces the pyroptosis of hepatoma cells to exert the antitumor effect (2023-12-08)
期刊:JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 :3.6
引用产品: H22 细胞
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A Synergistic Combination of Oleanolic Acid and Apatinib to Enhance Antitumor Effect on Liver Cancer Cells and Protect against Hepatic Injury (2023-05-05)
期刊:Recent Patents on Anti-Cancer Drug Discovery
DOI:10.2174/1574892818666230417093208
影响因子 :2.8
引用产品: H22 细胞
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ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression (2022-08-01)
期刊:International Journal of Biological Sciences
影响因子 :10.8
引用产品: HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞 , Hep G2 细胞 , H22 细胞 , THP-1 细胞
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Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer (2022-12-10)
期刊:JOURNAL OF NANOBIOTECHNOLOGY
DOI:10.1186/s12951-022-01738-6
影响因子 :9.4
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Lactose-modified enzyme-sensitive branched polymers as a nanoscale liver cancer-targeting MRI contrast agent (2022-12-12)
期刊:Nanoscale
影响因子 :8.3
引用产品: H22 细胞
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Improved anti-hepatocellular carcinoma effect by enhanced Co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles (2022-07-06)
期刊:Materials Today Bio
DOI:10.1016/j.mtbio.2022.100350
影响因子 :8.2
引用产品: Hepa 1-6 细胞 , H22 细胞
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Fluorinated carboxymethyl chitosan-based nano-prodrugs for precisely synergistic chemotherapy (2022-12-20)
期刊:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI:10.1016/j.ijbiomac.2022.12.157
影响因子 :8.0
引用产品: H22 细胞 , Hep G2 细胞 , A549 [A-549] 细胞 , MCF7 [MCF-7] 细胞
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Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice (2022-12-05)
期刊:JOURNAL OF ETHNOPHARMACOLOGY
影响因子 :5.2
引用产品: H22 细胞
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Quercetin, the Ingredient of Xihuang Pills, Inhibits Hepatocellular Carcinoma by Regulating Autophagy and Macrophage Polarization (2022-12-20)
期刊:Frontiers in Bioscience-Landmark
影响因子 :3.1
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Effects of Sensitized Sorafenib with a Paeoniflorin and Geniposide Mixture on Liver Cancer via the NF-κB-HIF-2α-SerpinB3 Pathway (2022-10-15)
期刊:Evidence-based Complementary and Alternative Medicine
影响因子 :2.7
引用产品: H22 细胞
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Cantharidin-loaded biomimetic MOF nanoparticle cascade to enhance the Fenton reaction based on amplified photothermal therapy (2021-10-08)
期刊:Biomaterials Science
影响因子 :7.6
引用产品: Hep G2 细胞 , RAW 264.7 细胞 , Hepa 1-6 细胞 , H22 细胞
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Protective effects of low-temperature plasma on cisplatin-induced nephrotoxicity (2021-12-14)
期刊:Life Sciences
影响因子 :6.1
引用产品: H22 细胞
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Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic (2021-12-11)
期刊:Journal Of Ethnopharmacology
影响因子 :5.4
引用产品: H22 细胞
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KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D (2021-07-02)
期刊:Journal of Immunology Research
影响因子 :4.5
引用产品: HL-7702 [L-02; LO2] , SMMC-7721 细胞 , Hep G2 细胞 , H22 细胞
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Cistanche tubulosa Phenylethanoid Glycosides Induce Apoptosis of Hepatocellular Carcinoma Cells by Mitochondria-Dependent and MAPK Pathways and Enhance Antitumor Effect through Combination with Cisplatin: (2021-05-05)
期刊:Integrative Cancer Therapies
影响因子 :2.9
引用产品: H22 细胞
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Ultrasound Molecular Imaging as a Potential Non-invasive Diagnosis to Detect the Margin of Hepatocarcinoma via CSF-1R Targeting (2020-07-14)
期刊:FRONT BIOENG BIOTECH
影响因子 :5.7
引用产品: H22 细胞
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Radiosensitization potential of caffeic acid phenethyl ester and the long non-coding RNAs in response to 60Coγ radiation in mouse hepatoma cells (2020-12-24)
期刊:Radiation Physics and Chemistry
DOI:10.1016/j.radphyschem.2020.109326
影响因子 :2.9
引用产品: H22 细胞
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Antitumor Effects of Curcumin and Glycyrrhetinic Acid-Modified Curcumin-Loaded Cationic Liposome by Intratumoral Administration (2020-05-30)
期刊:Evidence-Based Complementary and Alternative Medicine
影响因子 :2.7
引用产品: H22 细胞
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Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells (2019-10-31)
期刊:Gastroenterology
DOI:10.1053/j.gastro.2019.10.025
影响因子 :29.4
引用产品: H22 细胞 , Hepa 1-6 细胞
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Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells (2019-04-23)
期刊:Nanoscale
影响因子 :6.7
引用产品: H22 细胞
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EGCG enhances cancer cells sensitivity under 60Coγ radiation based on miR-34a/Sirt1/p53 (2019-09-05)
期刊:Food And Chemical Toxicology
影响因子 :4.3
引用产品: H22 细胞
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