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产品概述
| 名称 | B16 (小鼠黑色素瘤细胞) (STR鉴定正确) |
| 别称 | B-16; B16 melanoma; B16 subline B78; B78 |
| 种属 | C57BL/6小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:4-1:8 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | B16系列细胞，使用DMEM培养时可能出现黑色素快速积累，细胞不增殖或死亡的情况，该细胞正常扩增冻存请使用RPMI-1640完培，若您需要进行分泌黑色素等后续相关实验，可以在扩增冻存细胞后更换为DMEM培养来满足实验设计。 |
| 背景描述 | B16细胞是一株小鼠黑素瘤细胞。 |
| 年龄（性别） | 不详 |
| 组织来源 | 黑素瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 黑色素瘤细胞 |
| 生物安全等级 | BSL-1 |
| 保藏机构 | JCRB; JCRB0202 KCB; KCB 93030YJ RCB; RCB1283 TKG; TKG 0144 |
STR鉴定
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STR位点信息
18-3 15,16 6-7 15,16 5-5 16,20 X-1 28 1-2 19,20 7-1 26.2 8-1 16,17 1-1 17,18 19-2 13 15-3 22.3,23.3 12-1 17,18 6-4 18,19 4-2 20.3,21.3 3-2 14,15 2-1 16 13-1 17.1,18.1
11-2 16,17 17-2 15,16,17 -
STR鉴定图
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参考文献
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Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy (2025-01-11)
期刊：Nature Communications
DOI：10.1038/s41467-025-55905-y
影响因子 ：14.7
引用产品： MCF7 [MCF-7] 细胞 , B16 细胞 , CT26.WT 细胞 , 4T1 细胞 , PANC-1 细胞
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Silencing of SIRPα enhances the antitumor efficacy of CAR-M in solid tumors (2024-10-08)
期刊：Cellular & Molecular Immunology
DOI：10.1038/s41423-024-01220-3
影响因子 ：21.8
引用产品： THP-1 细胞 , SK-OV-3 细胞 , DLD-1 细胞 , AsPC-1 细胞 , MC38 细胞 , B16 细胞 , SK-BR-3 [SKBR3] 细胞 , ID8 细胞
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Light-activated polymeric crosslinked nanocarriers as a checkpoint blockade immunoregulatory platform for synergistic tumor therapy (2024-08-22)
期刊：Materials Today
DOI：10.1016/j.mattod.2024.07.012
影响因子 ：21.1
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The tRNA Gm18 methyltransferase TARBP1 promotes hepatocellular carcinoma progression via metabolic reprogramming of glutamine (2024-06-12)
期刊：CELL DEATH AND DIFFERENTIATION
DOI：10.1038/s41418-024-01323-4
影响因子 ：13.7
引用产品： Hep G2 细胞 , B16 细胞 , PLC/PRF/5 细胞
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ATP-adenosine axis regulation combined with microneedle assisted photoimmunotherapy to boost the immunotherapy efficiency (2024-01-23)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2024.01.035
影响因子 ：10.8
引用产品： B16 细胞
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Bacterial outer membrane vesicle-cancer cell hybrid membrane-coated nanoparticles for sonodynamic therapy in the treatment of breast cancer bone metastasis (2024-06-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-024-02619-w
影响因子 ：10.6
引用产品： 4T1 细胞 , DMEM/F12 培养基 , B16 细胞 , U-2 OS [U2OS] 细胞
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“All-in-one” metal polyphenol network nanocapsules integrated microneedle patches for lipophagy fueled ferroptosis-mediated multimodal therapy (2024-07-31)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2024.07.063
影响因子 ：10.5
引用产品： B16 细胞
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A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects (2024-04-23)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-024-02409-4
影响因子 ：10.2
引用产品： B16 细胞 , NCTC clone 929 [L cell, L-929] 细胞 , 人脐静脉内皮细胞
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Antitumor Therapy through Photothermal Performance Synergized with Catalytic Activity Based on the Boron Cluster Supramolecular Frameworks (2024-06-20)
期刊：ACS Applied Materials & Interfaces
影响因子 ：8.3
引用产品： B16 细胞
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Ionic liquid combined with cationic liposome co-delivers microphthalmia-associated transcription factor small interfering RNA to regulate melanogenesis (2024-09-26)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2024.136027
影响因子 ：7.7
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INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling (2024-09-02)
期刊：ACTA PHARMACOLOGICA SINICA
DOI：10.1038/s41401-024-01381-x
影响因子 ：6.9
引用产品： 293T [HEK-293T] 细胞 , B16 细胞 , MC38 细胞 , CT26.WT 细胞 , 4T1 细胞
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Sesquiterpene lactone from Artemisia argyi inhibited cancer proliferation by inducing apoptosis and ferroptosis via key cell metabolism enzyme NDUFA4 (2024-12-05)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.156312
影响因子 ：6.7
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Novel mRNA adjuvant ImmunER enhances prostate cancer tumor-associated antigen mRNA therapy via augmenting T cell activity (2024-06-27)
期刊：OncoImmunology
DOI：10.1080/2162402X.2024.2373526
影响因子 ：6.5
引用产品： DC2.4 细胞 , B16 细胞 , 293 [HEK-293] 细胞 , 293T [HEK-293T] 细胞 , TC-1 细胞
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Identification of Chemical Constituents from Leaves and Stems of Alpinia oxyphylla: Potential Antioxidant and Tyrosinase Inhibitory Properties (2024-12-16)
期刊：Antioxidants
影响因子 ：6.0
引用产品： B16 细胞
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2-(2-Phenylethyl)chromone dimers as melanin production inhibitors from agarwood of Gyrinops walla Gaertn (2024-11-26)
期刊：INDUSTRIAL CROPS AND PRODUCTS
DOI：10.1016/j.indcrop.2024.120147
影响因子 ：5.6
引用产品： B16 细胞
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Anti-Tumor Therapy through High ROS Performance induced by Ag Nanoenzyme from Boron Cluster with Halloysite Clay Nanotubes (2024-06-25)
期刊：COLLOIDS AND SURFACES B-BIOINTERFACES
DOI：10.1016/j.colsurfb.2024.114060
影响因子 ：5.4
引用产品： B16 细胞
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Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer (2024-12-06)
期刊：Journal of Inflammation Research
影响因子 ：4.2
引用产品： LLC [LL/2; LLC1] 细胞 , B16 细胞
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Edible bird's nest peptide (EBNP) with high whitening activity: Sequences analysis, whitening activity characterization and molecular docking study (2024-12-02)
期刊：Journal of Functional Foods
影响因子 ：3.8
引用产品： B16 细胞 , 0.25%胰蛋白酶溶液（含EDTA，溶于PBS） , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液（双抗），100×
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Newly identified peptide Nigrocin-OA27 inhibits UVB induced melanin production via the MITF/TYR pathway (2024-04-11)
期刊：PEPTIDES
DOI：10.1016/j.peptides.2024.171215
影响因子 ：3.0
引用产品： B16 细胞
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Design, Synthesis, Biological Evaluation and Molecular Docking Studies of 5-fluorouracil-dithiocarbamate Conjugates (2024-05-01)
期刊：Letters in Drug Design & Discovery
DOI：10.2174/1570180820666230203113746
影响因子 ：1.2
引用产品： B16 细胞 , Hela 细胞 , U-87 MG 细胞
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A novel antidiuretic hormone governs tumour-induced renal dysfunction (2023-12-06)
期刊：NATURE
DOI：10.1038/s41586-023-06833-8
影响因子 ：64.8
引用产品： MFC 细胞 , B16 细胞 , HCT 116 细胞
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Circular single-stranded DNA as switchable vector for gene expression in mammalian cells (2023-10-20)
期刊：Nature Communications
DOI：10.1038/s41467-023-42437-6
影响因子 ：16.6
引用产品： B16 细胞 , MCF7 [MCF-7] 细胞 , AC16 细胞 , U-87 MG 细胞 , Hela 细胞 , HELF 细胞 , 293T [HEK-293T] 细胞 , Hepa 1-6 细胞 , NCTC clone 929 [L cell, L-929] 细胞 , A549 [A-549] 细胞 , 5637 细胞 , Ishikawa 细胞 , LoVo 细胞
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CD44 targeting nanodrug based on chondroitin sulfate for melanoma therapy by inducing mitochondrial apoptosis pathways (2023-08-02)
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2023.121255
影响因子 ：11.2
引用产品： EA.hy926 细胞 , B16 细胞
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Microneedle-assisted vaccination combined with autophagy regulation for antitumor immunotherapy (2023-04-24)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2023.04.031
影响因子 ：10.8
引用产品： B16 细胞
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Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell-Mediated Tumor Immunotherapy (2023-02-18)
期刊：Advanced Healthcare Materials
影响因子 ：10.0
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Delivery of Mrna Vaccine with 1, 2-diesters-derived Lipids Elicits Fast Liver Clearance for Safe and Effective Cancer Immunotherapy. (2023-11-21)
期刊：Advanced Healthcare Materials
影响因子 ：10.0
引用产品： B16 细胞 , RM-1 细胞 , DC2.4 细胞 , 293 [HEK-293] 细胞
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Synthesis of iron-boride/carbon-nitride composites and their applications in chemodynamic therapy (2023-12-14)
期刊：JOURNAL OF COLLOID AND INTERFACE SCIENCE
DOI：10.1016/j.jcis.2023.12.078
影响因子 ：9.9
引用产品： B16 细胞
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Janus-Inspired Core–Shell Structure Hydrogel Programmatically Releases Melatonin for Reconstruction of Postoperative Bone Tumor (2023-01-05)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： U-2 OS [U2OS] 细胞 , MG-63 细胞 , B16 细胞
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Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy (2023-11-08)
期刊：Cell Chemical Biology
DOI：10.1016/j.chembiol.2023.10.010
影响因子 ：8.6
引用产品： EMT6 [EMT-6] 细胞 , MC38 细胞 , B16 细胞 , CT26.WT 细胞
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High-contrast tumor imaging via a de novo designed aminopeptidase N targeted fluorogenic probe (2023-12-04)
期刊：SENSORS AND ACTUATORS B-CHEMICAL
影响因子 ：8.4
引用产品： 4T1 细胞 , B16 细胞 , A549 [A-549] 细胞 , NCI-H1299 细胞 , HL-7702 [L-02; LO2] 细胞 , BEAS-2B 细胞 , Hep G2 细胞 , Malme-3M 细胞
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In situ administration of temperature-sensitive hydrogel composite loading paclitaxel microspheres and cisplatin for the treatment of melanoma (2023-02-10)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2023.114380
影响因子 ：7.5
引用产品： B16 细胞
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Study of the antiaging effects of bird's nest peptide based on biochemical, cellular, and animal models (2023-03-05)
期刊：Journal of Functional Foods
影响因子 ：5.6
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Peptide OA-VI12 restrains melanogenesis in B16 cells and C57B/6 mouse ear skin via the miR-122-5p/Mitf/Tyr axis (2023-10-04)
期刊：AMINO ACIDS
DOI：10.1007/s00726-023-03341-x
影响因子 ：3.5
引用产品： B16 细胞
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Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer (2022-12-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-022-01738-6
影响因子 ：9.4
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Retraction of “Label-Free Isolation of Low-Adhesion Cells with Stem Properties for Cancer Stem Cell-Specific Drug Evaluation” (2022-09-19)
期刊：ANALYTICAL CHEMISTRY
DOI：10.1021/acs.analchem.2c00444
影响因子 ：8.0
引用产品： MCF7 [MCF-7] 细胞 , MDA-MB-231 细胞 , SUM159PT 细胞 , B16 细胞 , MDA-MB-435 细胞 , SK-BR-3 [SKBR3] 细胞 , McCoy's 5A 培养基
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Promotion of Melanoma Cell Proliferation by Cyclic Straining through Regulatory Morphogenesis (2022-10-06)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：6.2
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Pulse width and intensity effects of pulsed electric fields on cancerous and normal skin cells (2022-10-27)
期刊：Scientific Reports
DOI：10.1038/s41598-022-22874-x
影响因子 ：5.0
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Bioassay-guided separation and identification of the anticancer composition from Curcuma longa L. by the combination strategy of methanol gradient countercurrent chromatography and ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (2022-10-14)
期刊：JOURNAL OF SEPARATION SCIENCE
影响因子 ：3.6
引用产品： B16 细胞 , RPMI-1640 培养基
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In Situ Self-Assembly Nanomicelle Microneedles for Enhanced Photoimmunotherapy via Autophagy Regulation Strategy (2021-02-23)
期刊：ACS Nano
影响因子 ：17.1
引用产品： B16 细胞
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Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study (2020-10-29)
期刊：Acta Pharmaceutica Sinica B
DOI：10.1016/j.apsb.2020.10.023
影响因子 ：14.5
引用产品： B16 细胞 , RAW 264.7 细胞
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Dissolving microneedles integrated with pH-responsive micelles containing AIEgen with ultra-photostability for enhancing melanoma photothermal therapy (2020-09-10)
期刊：Biomaterials Science
影响因子 ：6.6
引用产品： B16 细胞
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A Digital Controlled Pulse Generator for a Possible Tumor Therapy Combining Irreversible Electroporation With Nanosecond Pulse Stimulation (2020-04-17)
期刊：IEEE Transactions on Biomedical Circuits and Systems
DOI：10.1109/TBCAS.2020.2987376
影响因子 ：5.1
引用产品： B16 细胞
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A colorimetric and near -infrared ratiometric fluorescent probe for the determination of endogenous tyrosinase activity based on cyanine aggregation (2019-09-21)
期刊：Analyst
影响因子 ：4.2
引用产品： Hela 细胞 , MCF7 [MCF-7] 细胞 , B16 细胞 , PUMC-HUVEC-T1
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