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产品概述
| 名称 | H22 (小鼠肝癌细胞) (STR鉴定正确) |
| 别称 | Hepatoma-22; Hepatoma 22 |
| 种属 | 小鼠 |
| 生长特性 | 悬浮细胞 |
| 细胞形态 | 淋巴母细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 3×10^5-5×10^5cells/mL |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | H22细胞是小鼠腹水瘤细胞，体外培养传代4-5代左右，细胞活力会将低，状态会变差，可通过腹水培养恢复细胞活力。该细胞为悬浮细胞，请注意离心收集细胞悬液；请勿直接倒掉细胞培养液。 |
| 背景描述 | H22细胞是分离自小鼠腹水，由大连医科学院建立。 |
| 年龄（性别） | 不详 |
| 组织来源 | 肝；肝癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肝胆癌细胞 |
STR鉴定
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STR位点信息
18-3 11,17 6-7 13 5-5 14 X-1 25 1-2 18,19 7-1 24.2 8-1 17,18 1-1 15,16 19-2 13 15-3 19.3,20.3,25.3 12-1 17 6-4 15.3,16.3 4-2 19.3,20.3 3-2 13,14 2-1 9 13-1 16.2
11-2 16 17-2 13,15 -
STR鉴定图
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参考文献
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Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma (2024-02-02)
期刊：MOLECULAR THERAPY
DOI：10.1016/j.ymthe.2024.01.032
影响因子 ：12.4
引用产品： H22 细胞
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The combination of Brassica rapa L. polysaccharides and cisplatin enhances the anti liver cancer effect and improves intestinal microbiota and metabolic disorders (2024-03-07)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2024.130706
影响因子 ：8.2
引用产品： H22 细胞
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Glycyrrhizic Acid-Based Liposome for Tumor-Targeted Delivery of Cantharidin (2024-01-02)
期刊：ACS Applied Nano Materials
影响因子 ：5.9
引用产品： H22 细胞
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Astaxanthin exerts an adjunctive anti-cancer effect through the modulation of gut microbiota and mucosal immunity (2024-01-28)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.111553
影响因子 ：5.6
引用产品： H22 细胞
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Pathogenic Th17 cell-mediated liver fibrosis contributes to resistance to PD-L1 antibody immunotherapy in hepatocellular carcinoma (2024-02-13)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2024.111601
影响因子 ：5.6
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Paeoniflorin increases the anti-tumor efficacy of sorafenib in tumor-bearing mice with liver cancer via suppressing the NF-κb/PD-l1 axis (2024-01-13)
期刊：Heliyon
DOI：10.1016/j.heliyon.2024.e24461
影响因子 ：4.0
引用产品： H22 细胞
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Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions (2023-04-17)
期刊：Journal of Advanced Research
DOI：10.1016/j.jare.2023.04.008
影响因子 ：10.7
引用产品： H22 细胞
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Nanoparticles prepared by polysaccharides extracted from Biyang floral mushroom loaded with resveratrol: Characterization, bioactivity and release behavior under in vitro digestion (2023-06-12)
期刊：FOOD CHEMISTRY
DOI：10.1016/j.foodchem.2023.136612
影响因子 ：8.8
引用产品： H22 细胞
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Astaxanthin slows down skeletal muscle atrophy in H22 tumor-bearing mice during sorafenib treatment by modulating the gut microbiota (2023-12-20)
期刊：Food & Function
影响因子 ：6.1
引用产品： H22 细胞
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Antitumor Activity of Carboxymethyl Pachymaran with Different Molecular Weights Based on Immunomodulatory and Gut Microbiota (2023-10-25)
期刊：Nutrients
影响因子 ：5.9
引用产品： H22 细胞
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Engineering M1-derived nanovesicles loading with docosahexaenoic acid synergizes ferroptosis and immune activation for treating hepatocellular carcinoma (2023-03-07)
期刊：Cancer Nanotechnology
DOI：10.1186/s12645-023-00166-x
影响因子 ：5.7
引用产品： H22 细胞
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Enhancing anti-tumor therapy with agmatine-cholesterol conjugate liposomes: in vitro and in vivo evidence (2023-09-27)
期刊：Drug Delivery and Translational Research
DOI：10.1007/s13346-023-01433-5
影响因子 ：5.4
引用产品： H22 细胞
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Astaxanthin Supplementation Assists Sorafenib in Slowing Skeletal Muscle Atrophy in H22 Tumor-Bearing Mice via Reversing Abnormal Glucose Metabolism (2023-05-13)
期刊：MOLECULAR NUTRITION & FOOD RESEARCH
影响因子 ：5.2
引用产品： H22 细胞
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Comparative study on the anti-tumor effect of steroids derived from different organisms in H22 tumor-bearing mice and analysis of their mechanisms (2023-12-13)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.176269
影响因子 ：5.0
引用产品： H22 细胞
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CDK1-SRC Interaction-Dependent Transcriptional Activation of HSP90AB1 Promotes Antitumor Immunity in Hepatocellular Carcinoma (2023-11-10)
期刊：JOURNAL OF PROTEOME RESEARCH
DOI：10.1021/acs.jproteome.3c00379
影响因子 ：4.4
引用产品： HuH-7 细胞 , H22 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , DMEM高糖 培养基
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Ajmalicine induces the pyroptosis of hepatoma cells to exert the antitumor effect (2023-12-08)
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.6
引用产品： H22 细胞
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ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression (2022-08-01)
期刊：International Journal of Biological Sciences
影响因子 ：10.8
引用产品： HuH-7 细胞 , Hep 3B2.1-7 细胞 , SK-Hep-1 细胞 , Hep G2 细胞 , H22 细胞 , THP-1 细胞
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Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer (2022-12-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-022-01738-6
影响因子 ：9.4
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Lactose-modified enzyme-sensitive branched polymers as a nanoscale liver cancer-targeting MRI contrast agent (2022-12-12)
期刊：Nanoscale
影响因子 ：8.3
引用产品： H22 细胞
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Improved anti-hepatocellular carcinoma effect by enhanced Co-delivery of Tim-3 siRNA and sorafenib via multiple pH triggered drug-eluting nanoparticles (2007-02-20)
期刊：Materials Today Bio
DOI：10.1016/j.mtbio.2022.100350
影响因子 ：8.2
引用产品： Hepa 1-6 细胞 , H22 细胞
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Fluorinated carboxymethyl chitosan-based nano-prodrugs for precisely synergistic chemotherapy (2022-12-20)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2022.12.157
影响因子 ：8.0
引用产品： H22 细胞 , Hep G2 细胞 , A549 [A-549] 细胞 , MCF7 [MCF-7] 细胞
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Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice (2022-12-05)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.2
引用产品： H22 细胞
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Quercetin, the Ingredient of Xihuang Pills, Inhibits Hepatocellular Carcinoma by Regulating Autophagy and Macrophage Polarization (2022-12-20)
期刊：Frontiers in Bioscience-Landmark
影响因子 ：3.1
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Effects of Sensitized Sorafenib with a Paeoniflorin and Geniposide Mixture on Liver Cancer via the NF-κB-HIF-2α-SerpinB3 Pathway (2022-10-15)
期刊：Evidence-based Complementary and Alternative Medicine
影响因子 ：2.7
引用产品： H22 细胞
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Cantharidin-loaded biomimetic MOF nanoparticle cascade to enhance the Fenton reaction based on amplified photothermal therapy (2010-01-20)
期刊：Biomaterials Science
影响因子 ：7.6
引用产品： Hep G2 细胞 , RAW 264.7 细胞 , Hepa 1-6 细胞 , H22 细胞
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Protective effects of low-temperature plasma on cisplatin-induced nephrotoxicity (2012-01-20)
期刊：Life Sciences
影响因子 ：6.1
引用产品： H22 细胞
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Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic (2012-01-20)
期刊：Journal Of Ethnopharmacology
影响因子 ：5.4
引用产品： H22 细胞
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KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D (2007-01-20)
期刊：Journal of Immunology Research
影响因子 ：4.5
引用产品： HL-7702 [L-02; LO2] , SMMC-7721 细胞 , Hep G2 细胞 , H22 细胞
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Cistanche tubulosa Phenylethanoid Glycosides Induce Apoptosis of Hepatocellular Carcinoma Cells by Mitochondria-Dependent and MAPK Pathways and Enhance Antitumor Effect through Combination with Cisplatin: (2005-01-20)
期刊：Integrative Cancer Therapies
影响因子 ：2.9
引用产品： H22 细胞
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Ultrasound Molecular Imaging as a Potential Non-invasive Diagnosis to Detect the Margin of Hepatocarcinoma via CSF-1R Targeting (2007-00-20)
期刊：FRONT BIOENG BIOTECH
影响因子 ：5.7
引用产品： H22 细胞
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Radiosensitization potential of caffeic acid phenethyl ester and the long non-coding RNAs in response to 60Coγ radiation in mouse hepatoma cells (2012-00-20)
期刊：Radiation Physics and Chemistry
DOI：10.1016/j.radphyschem.2020.109326
影响因子 ：2.9
引用产品： H22 细胞
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Antitumor Effects of Curcumin and Glycyrrhetinic Acid-Modified Curcumin-Loaded Cationic Liposome by Intratumoral Administration (2005-00-20)
期刊：Evidence-Based Complementary and Alternative Medicine
影响因子 ：2.7
引用产品： H22 细胞
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Disruption of SIRT7 Increases the Efficacy of Checkpoint Inhibitor via MEF2D Regulation of Programmed Cell Death 1 Ligand 1 in Hepatocellular Carcinoma Cells (2010-09-20)
期刊：Gastroenterology
DOI：10.1053/j.gastro.2019.10.025
影响因子 ：29.4
引用产品： H22 细胞 , Hepa 1-6 细胞
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Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells (2004-09-20)
期刊：Nanoscale
影响因子 ：6.7
引用产品： H22 细胞
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EGCG enhances cancer cells sensitivity under 60Coγ radiation based on miR-34a/Sirt1/p53 (2009-09-20)
期刊：Food And Chemical Toxicology
影响因子 ：4.3
引用产品： H22 细胞
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