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产品概述
| 名称 | BxPC-3 (人原位胰腺腺癌细胞) (STR鉴定正确) |
| 别称 | BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | BxPC-3细胞不表达囊肿性纤维化跨膜电导调节子(CFTR)，CFTR阳性的细胞株是Capan-1。 |
| 年龄（性别） | 女性；61岁 |
| 组织来源 | 胰腺；腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~48-60 hours |
| 致瘤性 | Yes, Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
| 基因表达情况 | mucin; pancreas cancer specific antigen (pancreas cancer associated antigen); carcinoembryonic antigen (CEA) |
| 保藏机构 | ATCC; CRL-1687 BCRC; 60283 BCRJ; 0056 DSMZ; ACC-760 ECACC; 93120816 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 13 D2S1338 17,19 D3S1358 14,16 D5S818 11 D7S820 10,13 D8S1179 13 D13S317 11 D16S539 9,11 D18S51 12 D19S433 13,16.2 D21S11 29 FGA 20,21 PentaD 14 PentaE 12,14 TH01 9 TPOX 8 vWA 14,18 D6S1043 12 D12S391 19.3,20 D2S441 12,14 -
STR鉴定图
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参考文献
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FOXM1-Driven CKS1B Upregulation Promotes Pancreatic Cancer Progression and Therapeutic Resistance (2025-01-13)
期刊：International Journal of Biological Sciences
影响因子 ：8.2
引用产品： BxPC-3 细胞 , CFPAC-1 细胞 , MIA PaCa-2 细胞 , PANC-1 细胞 , Panc02 细胞 , PL45 细胞
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Cancer-Associated Fibroblast-Secreted Exosomes Regulate Macrophage Polarization in Pancreatic Cancer via the NOD1 Pathway (2025-01-05)
期刊：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 ：3.2
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D3S-001, a KRAS G12C inhibitor with rapid target engagement kinetics, overcomes nucleotide cycling and demonstrates robust preclinical and clinical activities (2024-05-08)
期刊：Cancer Discovery
DOI：10.1158/2159-8290.CD-24-0006
影响因子 ：28.2
引用产品： AGS 细胞 , A549 [A-549] 细胞 , A-375 细胞 , KYSE-410 细胞 , NCI-H358 细胞 , AsPC-1 细胞 , BxPC-3 细胞 , HCT-15 细胞 , HCT 116 细胞 , SW480 [SW-480] 细胞 , SW620 细胞
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Orchestrated desaturation reprogramming from stearoyl-CoA desaturase to fatty acid desaturase 2 in cancer epithelial-mesenchymal transition and metastasis (2024-12-25)
期刊：Cancer Communications
影响因子 ：20.1
引用产品： T24 [T-24] 细胞 , SW 780 [SW-780, SW780] 细胞 , MDA-MB-231 细胞 , MCF7 [MCF-7] 细胞 , PANC-1 细胞 , BxPC-3 细胞 , 293T [HEK-293T] 细胞
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A collagenase-decorated Cu-based nanotheranostics: remodeling extracellular matrix for optimizing cuproptosis and MRI in pancreatic ductal adenocarcinoma (2024-11-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-024-02968-6
影响因子 ：10.6
引用产品： BxPC-3 细胞
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HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells (2024-03-16)
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06592-y
影响因子 ：9.0
引用产品： PANC-1 细胞 , MIA PaCa-2 细胞 , BxPC-3 细胞
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Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2 (2024-01-26)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2024.1347683
影响因子 ：7.3
引用产品： PANC-1 细胞 , BxPC-3 细胞 , RPMI-1640 培养基
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Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression (2024-06-19)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.06.014
影响因子 ：7.1
引用产品： HT-1080 [HT1080] 细胞 , BxPC-3 细胞 , HuH-7 细胞 , U-937 细胞 , SU-DHL-4 细胞 , Jurkat, Clone E6-1 细胞 , NB4 细胞 , Caov-3 细胞
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Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells (2024-02-21)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2024.155392
影响因子 ：6.7
引用产品： BxPC-3 细胞
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BNIP3+ fibroblasts associated with hypoxia and inflammation predict prognosis and immunotherapy response in pancreatic ductal adenocarcinoma (2024-10-14)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-024-05674-x
影响因子 ：6.1
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Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor (2024-06-18)
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2024.116612
影响因子 ：6.0
引用产品： KATO III [KATO 3] 细胞 , AN3 CA 细胞 , A2780 细胞 , BxPC-3 细胞 , MCF7 [MCF-7] 细胞 , HuH-7 细胞 , MDA-MB-231 细胞 , HCT 116 细胞 , 22RV1 细胞 , HL-7702 [L-02; LO2] 细胞 , 293 [HEK-293] 细胞 , 293T [HEK-293T] 细胞 , NCI-H1975 细胞
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Fasting-Mimicking Diet Prevents Pancreatic Carcinogenesis via Gut Microbiota and Metabolites (2024-11-08)
期刊：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
影响因子 ：5.7
引用产品： PANC-1 细胞 , hTERT-HPNE 细胞 , BxPC-3 细胞 , MIA PaCa-2 细胞 , AsPC-1 细胞
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LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4 (2024-03-19)
期刊：Biology Direct
DOI：10.1186/s13062-024-00463-4
影响因子 ：5.5
引用产品： PANC-1 细胞 , BxPC-3 细胞 , Capan-2 细胞 , AsPC-1 细胞 , SW 1990 细胞 , HPED-6 细胞
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SERPINA1 promotes the invasion, metastasis, and proliferation of pancreatic ductal adenocarcinoma via the PI3K/Akt/NF-κB pathway (2024-10-18)
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：5.3
引用产品： CFPAC-1 细胞 , BxPC-3 细胞
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Cell-selective imaging of MicroRNAs via an enzyme-controlled engineered DNA nanodevice (2024-10-18)
期刊：MICROCHEMICAL JOURNAL
DOI：10.1016/j.microc.2024.111953
影响因子 ：4.9
引用产品： MDA-MB-231 细胞 , BxPC-3 细胞 , Hela 细胞
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A novel coordination polymer array sensor for differential detection of nitroimidazole antibiotics (2024-12-07)
期刊：MICROCHEMICAL JOURNAL
DOI：10.1016/j.microc.2024.112405
影响因子 ：4.9
引用产品： BxPC-3 细胞
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PELI1 overexpression contributes to pancreatic cancer progression through upregulating ubiquitination-mediated INPP5J degradation (2024-04-27)
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2024.111194
影响因子 ：4.8
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Cancer-associated fibroblast-derived MMP11 promotes tumor progression in pancreatic cancer (2024-12-05)
期刊：CANCER SCIENCE
影响因子 ：4.5
引用产品： AsPC-1 细胞 , BxPC-3 细胞 , PANC-1 细胞 , RPMI-1640 培养基 , DMEM高糖 培养基 , 青霉素-链霉素溶液（双抗），100×
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Network-based prediction of anti-cancer drug combinations (2024-08-15)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2024.1418902
影响因子 ：4.4
引用产品： SW480 [SW-480] 细胞 , HCT 116 细胞 , BxPC-3 细胞
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HnRNPAB promotes pancreatic ductal adenocarcinoma extravasation and liver metastasis by stablizing MYC mRNA (2024-07-05)
期刊：MOLECULAR CANCER RESEARCH
DOI：10.1158/1541-7786.MCR-24-0110
影响因子 ：4.1
引用产品： AsPC-1 细胞 , BxPC-3 细胞 , PANC-1 细胞 , MIA PaCa-2 细胞 , HUV-EC-C [HUVEC] 细胞
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Design and synthesis of novel site-specific antibody-drug conjugates that target TROP2 (2024-07-02)
期刊：BIOORGANIC & MEDICINAL CHEMISTRY
影响因子 ：3.3
引用产品： DMEM高糖 培养基 , MEM 培养基 , 0.25%胰蛋白酶溶液（含EDTA，溶于PBS） , NCI-N87 [N87] 细胞 , RPMI-1640 培养基 , BxPC-3 细胞 , Calu-6 细胞 , FaDu 细胞 , IMDM 培养基
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Enhancing therapeutic efficacy in homologous recombination-proficient pancreatic cancer via the combination of PARP1-PROTAC and a BRD4 inhibitor (2024-10-26)
期刊：BIOORGANIC & MEDICINAL CHEMISTRY
影响因子 ：3.3
引用产品： BxPC-3 细胞 , PANC-1 细胞 , Capan-1 细胞
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The BCL2-associated athanogene-3–Interferon-induced transmembrane protein 2 axis enhances pancreatic ductal adenocarcinoma growth via the Mitogen-activated protein kinase signaling pathway (2024-08-30)
期刊：CARCINOGENESIS
影响因子 ：3.3
引用产品： MIA PaCa-2 细胞 , PANC-1 细胞 , SU.86.86 细胞 , BxPC-3 细胞 , NK-92 细胞
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FAM53B promotes pancreatic ductal adenocarcinoma metastasis by regulating macrophage M2 polarization (2024-04-15)
期刊：World Journal of Gastrointestinal Oncology
影响因子 ：3.0
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GPX3 represses pancreatic cancer cell proliferation, migration and invasion, and improves their chemo?sensitivity by regulating the JNK/c?Jun signaling pathway (2024-01-29)
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.7
引用产品： BxPC-3 细胞 , SW 1990 细胞 , PANC-1 细胞
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Prognostic biomarker MICAL2 and associates with proliferation, migration and immune infiltration in pancreatic adenocarcinoma (2024-12-11)
期刊：JOURNAL OF APPLIED GENETICS
DOI：10.1007/s13353-024-00919-3
影响因子 ：2.0
引用产品： BxPC-3 细胞 , SW 1990 细胞 , PANC-1 细胞 , AsPC-1 细胞
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Accurate Visualization of Metabolic Aberrations in Cancer Cells by Temperature Mapping with Quantum Coherence Modulation Microscopy (2023-04-27)
期刊：ACS Nano
影响因子 ：17.1
引用产品： A549 [A-549] 细胞 , Hela 细胞 , Hep G2 细胞 , BxPC-3 细胞 , DU 145 细胞 , 4T1 细胞 , BEAS-2B 细胞 , MET-5A 细胞 , 潮霉素B溶液 (50mg/mL)
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MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression (2023-10-31)
期刊：EMBO JOURNAL
影响因子 ：11.4
引用产品： 293T [HEK-293T] 细胞 , PANC-1 细胞 , CFPAC-1 细胞 , BxPC-3 细胞 , SW 1990 细胞
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Radionuclide labeled nanocarrier for imaging guided combined radionuclide, sonodynamic, and photothermal therapy of pancreatic tumours (2023-03-30)
期刊：JOURNAL OF COLLOID AND INTERFACE SCIENCE
DOI：10.1016/j.jcis.2023.03.111
影响因子 ：9.9
引用产品： BxPC-3 细胞
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pH-Sensitive Biomimetic Nanosystem Based on Large-Pore Mesoporous Silica Nanoparticles with High Hyaluronidase Loading for Tumor Deep Penetration (2023-08-05)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： BxPC-3 细胞
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METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation (2023-03-28)
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05715-1
影响因子 ：9.0
引用产品： SW 1990 细胞 , PANC-1 细胞 , BxPC-3 细胞
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Pan-cancer analysis of Krüppel-like factor 3 and its carcinogenesis in pancreatic cancer (2023-08-03)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1167018
影响因子 ：7.3
引用产品： BxPC-3 细胞
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Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy (2023-06-27)
期刊：APOPTOSIS
DOI：10.1007/s10495-023-01868-8
影响因子 ：7.2
引用产品： HPNE 细胞 , CFPAC-1 细胞 , SW 1990 细胞 , BxPC-3 细胞
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5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis (2023-10-12)
期刊：Biomolecules
影响因子 ：5.5
引用产品： MIA PaCa-2 细胞 , PANC-1 细胞 , CFPAC-1 细胞 , Capan-2 细胞 , SW 1990 细胞 , BxPC-3 细胞 , AsPC-1 细胞 , 人胰腺上皮细胞
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RBM15 Promates the Proliferation, Migration and Invasion of Pancreatic Cancer Cell Lines (2023-02-08)
期刊：Cancers
影响因子 ：5.2
引用产品： HPNE 细胞 , CFPAC-1 细胞 , BxPC-3 细胞
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COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation (2023-02-26)
期刊：Cancers
影响因子 ：5.2
引用产品： PANC-1 细胞 , BxPC-3 细胞 , CFPAC-1 细胞 , PATU8988 细胞 , AsPC-1 细胞 , MIA PaCa-2 细胞
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Aberrant expression of PELI1 caused by Jagged1 accelerates the malignant phenotype of pancreatic cancer (2023-08-30)
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2023.110877
影响因子 ：4.8
引用产品： BxPC-3 细胞 , IMDM 培养基 , SW 1990细胞专用培养基 (L15)
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Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer (2023-10-24)
期刊：Frontiers in Oncology
影响因子 ：4.7
引用产品： BxPC-3 细胞 , PANC-1 细胞 , CFPAC-1 细胞 , MIA PaCa-2 细胞
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Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway (2023-08-19)
期刊：FOOD AND CHEMICAL TOXICOLOGY
影响因子 ：4.3
引用产品： Hep G2 细胞 , BEL-7404 细胞 , BxPC-3 细胞
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PCDH1, a poor prognostic biomarker and potential target for pancreatic adenocarcinoma metastatic therapy (2023-11-13)
期刊：BMC CANCER
DOI：10.1186/s12885-023-11474-1
影响因子 ：3.8
引用产品： BxPC-3 细胞
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Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis (2023-10-30)
期刊：BMC CANCER
DOI：10.1186/s12885-023-11557-z
影响因子 ：3.8
引用产品： MIA PaCa-2 细胞 , PANC-1 细胞 , AsPC-1 细胞 , BxPC-3 细胞 , THP-1 细胞 , DMEM高糖 培养基 , RPMI-1640 培养基 , 特级胎牛血清 , 马血清 , 青霉素-链霉素溶液 (双抗)，100× , β-巯基乙醇 (55mM)，1000×
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Preparation and Characterization of PLGA-based Magnetic Polymer Nanoparticles for Targeting Pancreatic Adenocarcinoma (2023-03-01)
期刊：CURRENT PHARMACEUTICAL DESIGN
DOI：10.2174/1381612829666230324091555
影响因子 ：3.1
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Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer (2023-02-12)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
引用产品： PANC-1 细胞 , MIA PaCa-2 细胞 , BxPC-3 细胞 , SW 1990 细胞 , AsPC-1 细胞
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The DEAD-box RNA helicase, DDX60, Suppresses immunotherapy and promotes malignant progression of pancreatic cancer (2023-05-26)
期刊：Biochemistry and Biophysics Reports
DOI：10.1016/j.bbrep.2023.101488
影响因子 ：2.7
引用产品： BxPC-3 细胞
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Synthesis of Copper and Cobalt complexes with a Hydrothermal Method and Their Applications in Antibiological Activity (2023-12-01)
期刊：ChemistrySelect
影响因子 ：2.1
引用产品： BxPC-3 细胞
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ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma. (2023-11-22)
期刊：HISTOLOGY AND HISTOPATHOLOGY
影响因子 ：2.0
引用产品： 青霉素-链霉素溶液（双抗），100× , AsPC-1 细胞 , Annexin V-FITC/PI荧光双染细胞凋亡检测试剂盒 , CFPAC-1 细胞 , Capan-1 细胞 , BxPC-3 细胞
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Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment (2022-12-21)
期刊：Nano Today
DOI：10.1016/j.nantod.2022.101733
影响因子 ：19.0
引用产品： BxPC-3 细胞
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Albumin binding revitalizes NQO1 bioactivatable drugs as novel therapeutics for pancreatic cancer (2022-08-04)
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2022.07.033
影响因子 ：11.5
引用产品： MIA PaCa-2 细胞 , BxPC-3 细胞 , AsPC-1 细胞 , SW 1990 细胞
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ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway (2022-04-07)
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02310-8
影响因子 ：11.3
引用产品： PANC-1 细胞 , BxPC-3 细胞 , Capan-2 细胞 , SW 1990 细胞 , AsPC-1 细胞
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Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer (2022-12-10)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-022-01738-6
影响因子 ：9.4
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Exosomal LINC00460/miR-503-5p/ANLN positive feedback loop aggravates pancreatic cancer progression through regulating T cell–mediated cytotoxicity and PD-1 checkpoint (2022-12-08)
期刊：Cancer Cell International
DOI：10.1186/s12935-022-02741-5
影响因子 ：6.4
引用产品： AsPC-1 细胞 , BxPC-3 细胞 , SW 1990 细胞 , PANC-1 细胞 , MIA PaCa-2 细胞 , THP-1 细胞
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Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2 (2022-09-20)
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：6.1
引用产品： PANC-1 细胞 , MIA PaCa-2 细胞 , BxPC-3 细胞 , AsPC-1 细胞 , CFPAC-1 细胞 , SW 1990 细胞 , CFPAC-1细胞专用培养基 , SW 1990细胞专用培养基 (L15)
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Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research (2022-01-08)
期刊：Bioengineered
DOI：10.1080/21655979.2021.2019873
影响因子 ：4.9
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GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma (2022-06-05)
期刊：PANCREATOLOGY
影响因子 ：4.0
引用产品： AsPC-1 细胞 , BxPC-3 细胞 , PANC-1 细胞 , MIA PaCa-2 细胞 , SW 1990 细胞
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IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway (2022-01-17)
期刊：Clinical & Translational Oncology
DOI：10.1007/s12094-021-02748-w
影响因子 ：3.4
引用产品： BxPC-3 细胞
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Construction and validation of a m6A RNA methylation and ferroptosis-related prognostic model for pancreatic cancer by integrated bioinformatics analysis. (2022-10-01)
期刊：Journal of Gastrointestinal Oncology
影响因子 ：2.6
引用产品： CFPAC-1 细胞 , PANC-1 细胞 , BxPC-3 细胞
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SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis (2021-07-24)
期刊：Cancer Letters
DOI：10.1016/j.canlet.2021.07.035
影响因子 ：9.7
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GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments (2021-08-30)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-021-03050-7
影响因子 ：7.4
引用产品： BxPC-3 细胞
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CMTM3 Overexpression Predicts Poor Survival and Promotes Proliferation and Migration in Pancreatic Cancer (2021-08-03)
期刊：Journal of Cancer
影响因子 ：3.9
引用产品： SW 1990 细胞 , AsPC-1 细胞 , PANC-1 细胞 , BxPC-3 细胞 , Capan-2 细胞
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Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway (2020-03-10)
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-020-00734-4
影响因子 ：3.4
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