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产品概述
| 名称 | MKN-45 (人胃癌细胞)(STR鉴定正确） |
| 种属 | 人 |
| 生长特性 | 半贴半悬 |
| 细胞形态 | 圆形 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | MKN-45 细胞是由 Hojo H建立，源于日本一位62岁低分化胃腺癌女性患者的肝转移灶。 |
| 年龄（性别） | 女性；62岁 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胃癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~30-60 hours |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 18 D3S1358 15,16 D5S818 10,11 D7S820 10,11 D8S1179 13,17 D13S317 8,11 D16S539 10 D18S51 16 D19S433 14,16.2 D21S11 31 FGA 19,24 PentaD 10 PentaE 10 TH01 7 TPOX 8 vWA 19 D6S1043 14 D12S391 26 D2S441 11 -
STR鉴定图
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参考文献
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Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes (2024-01-06)
期刊：FREE RADICAL BIOLOGY AND MEDICINE
DOI：10.1016/j.freeradbiomed.2024.01.002
影响因子 ：7.4
引用产品： AGS 细胞 , HGC-27 细胞 , MKN-7 [MKN7; MKN 7] 细胞 , MKN-45 细胞 , SNU-1 细胞 , NCI-N87 [N87] 细胞 , Ham's F-12 培养基
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CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation (2024-03-08)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-023-04625-2
影响因子 ：7.4
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Microfluidic device featuring micro-constrained channels for multi-parametric assessment of cellular biomechanics and high-precision mechanical phenotyping of gastric cells (2024-03-12)
期刊：ANALYTICA CHIMICA ACTA
影响因子 ：6.2
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CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3 (2024-02-29)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
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Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells (2024-02-07)
期刊：WORLD JOURNAL OF GASTROENTEROLOGY
影响因子 ：4.3
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Closed-loop of Catalyzed Lactate Oxidization Synergistically Sensitizes Apoptosis and Ferroptosis for Cancer Therapy (2024-02-01)
期刊：ChemNanoMat
影响因子 ：3.8
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Homeobox Protein BarH-like 1 Promotes Gastric Cancer Progression by Activating Coiled-Coil Domain-Containing Protein 178 (2024-02-15)
期刊：DIGESTIVE DISEASES AND SCIENCES
DOI：10.1007/s10620-024-08312-0
影响因子 ：3.1
引用产品： 人胃黏膜上皮细胞 , MKN-45 细胞 , AGS 细胞 , NCI-N87 [N87] 细胞 , KATO III [KATO 3] 细胞 , THP-1 细胞
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Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells (2024-02-15)
期刊：World Journal of Gastrointestinal Oncology
影响因子 ：3.0
引用产品： HGC-27 细胞 , MKN-45 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100×
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A prognostic marker LTBP1 is associated with epithelial mesenchymal transition and can promote the progression of gastric cancer (2024-02-15)
期刊：FUNCTIONAL & INTEGRATIVE GENOMICS
DOI：10.1007/s10142-024-01311-4
影响因子 ：2.9
引用产品： AGS 细胞 , HGC-27 细胞 , MKN-45 细胞 , GES-1 细胞 , RPMI-1640 培养基 , Ham's F-12 培养基
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KBTBD2 promotes proliferation and migration of gastric cancer via activating EGFR signaling pathway (2024-01-04)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
引用产品： AGS 细胞 , NCI-N87 [N87] 细胞 , MKN-45 细胞 , SUN-1 细胞 , HGC-27 细胞 , GES-1 细胞
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Transcription factor E2F3 activates CDC25B to regulate DNA damage and promote mitoxantrone resistance in stomach adenocarcinoma (2024-01-09)
期刊：MOLECULAR BIOLOGY REPORTS
DOI：10.1007/s11033-023-08933-0
影响因子 ：2.8
引用产品： GES-1 细胞 , MKN-45 细胞 , NUGC-3 细胞 , RPMI-1640 培养基 , Ham's F-12K 培养基 , DMEM高糖 培养基
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Hypoxia-responsive CAR-T cells exhibit reduced exhaustion and enhanced efficacy in solid tumors (2023-10-24)
期刊：CANCER RESEARCH
DOI：10.1158/0008-5472.CAN-23-1038
影响因子 ：11.2
引用产品： MKN-45 细胞
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Neutrophil extracellular traps promote angiogenesis in gastric cancer (2023-07-21)
期刊：Cell Communication and Signaling
DOI：10.1186/s12964-023-01196-z
影响因子 ：8.4
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Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis (2023-01-05)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
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Fucoxanthin inhibits gastric cancer lymphangiogenesis and metastasis by regulating Ran expression (2023-06-16)
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.154926
影响因子 ：7.9
引用产品： HGC-27 细胞 , AGS 细胞 , MKN-45 细胞 , MKN74 细胞 , MKN-7 [MKN7; MKN 7] 细胞
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The regulatory role of cancer stem cell marker gene CXCR4 in the growth and metastasis of gastric cancer (2023-09-07)
期刊：npj Precision Oncology
DOI：10.1038/s41698-023-00436-2
影响因子 ：7.9
引用产品： 293T [HEK-293T] 细胞 , MKN-45 细胞
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Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer (2023-01-05)
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-022-03845-2
影响因子 ：7.4
引用产品： GES-1 细胞 , AGS 细胞 , HGC-27 细胞 , KATO III [KATO 3] 细胞 , MKN-1 细胞 , MKN-45 细胞
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Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer (2023-03-03)
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1149989
影响因子 ：7.3
引用产品： GES-1 细胞 , AGS 细胞 , HGC-27 细胞 , KATO III [KATO 3] 细胞 , MKN-45 细胞
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RP11-789C1.1 inhibits gastric cancer cell proliferation and accelerates apoptosis via the ATR/CHK1 signaling pathway (2023-10-25)
期刊：CHINESE MEDICAL JOURNAL
DOI：10.1097/CM9.0000000000002869
影响因子 ：6.1
引用产品： AGS 细胞 , MKN-45 细胞 , BGC-823 细胞 , KATO III [KATO 3] 细胞 , HGC-27 细胞 , SGC-7901 细胞
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Glucose transporter 3 (GLUT3) promotes lactylation modifications by regulating lactate dehydrogenase A (LDHA) in gastric cancer (2023-12-01)
期刊：Cancer Cell International
DOI：10.1186/s12935-023-03162-8
影响因子 ：5.8
引用产品： GES-1 细胞 , AGS 细胞 , HGC-27 细胞 , KATO III [KATO 3] 细胞 , MKN-1 细胞 , MKN-45 细胞
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Insights into the inhibition of stomach cancer MKN45 cell growth by Poria cocos ethanol-soluble extract based on MAPK/PI3K signaling pathways and components cell fishing (2023-11-17)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
引用产品： MKN-45 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , RPMI-1640 培养基
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LINC01354 enhances the metastatic ability of gastric cancer cells by adjusting miR-153-5p/CADM2 expression (2023-06-15)
期刊：American Journal of Cancer Research
DOI：PMID:37424819
影响因子 ：5.3
引用产品： HGC-27 细胞 , NCI-N87 [N87] 细胞 , MKN-7 [MKN7; MKN 7] 细胞 , MKN-45 细胞 , SNU-1 细胞
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GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer (2023-05-26)
期刊：MEDIATORS OF INFLAMMATION
影响因子 ：4.6
引用产品： MKN-7 [MKN7; MKN 7] 细胞 , MKN-45 细胞
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Benzophenanthridine Alkaloid Chelerythrine Elicits Necroptosis of Gastric Cancer Cells via Selective Conjugation at the Redox Hyperreactive C-Terminal Sec498 Residue of Cytosolic Selenoprotein Thioredoxin Reductase (2023-09-28)
期刊：MOLECULES
影响因子 ：4.6
引用产品： NCI-N87 [N87] 细胞 , AGS 细胞 , MKN-45 细胞 , RPMI-1640 培养基 , 特级胎牛血清
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PKNOX1 acts as a transcription factor of DHH and promotes the progression of stomach adenocarcinoma by regulating the Hedgehog signalling pathway (2023-10-21)
期刊：INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
影响因子 ：3.5
引用产品： GES-1 细胞 , SNU-216 细胞 , HGC-27 细胞 , MKN-45 细胞 , AGS 细胞 , 293T [HEK-293T] 细胞
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The GLI2/CDH6 axis enhances migration, invasion and mitochondrial fission of stomach adenocarcinoma cells (2023-07-24)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2023.07.038
影响因子 ：3.1
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SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway (2023-03-17)
期刊：Canadian Journal of Gastroenterology and Hepatology
影响因子 ：2.7
引用产品： GES-1 细胞 , AGS 细胞 , HGC-27 细胞 , SNU-5 细胞 , MKN-45 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , Ham's F-12 培养基 , IMDM 培养基 , 293 [HEK-293] 细胞 , MEM (ATCC改良) 培养基
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RNF220 promotes gastric cancer growth and stemness via modulating the USP22/wnt/β-catenin pathway (2023-06-01)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2023.102123
影响因子 ：2.6
引用产品： MKN-28 细胞 , MKN-45 细胞 , AGS 细胞 , HGC-27 细胞 , GES-1 细胞 , Ham's F-12 培养基 , RPMI-1640 培养基 , 特级胎牛血清
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Oncogenic transmembrane protein 158 drives the PI3K/Akt signaling pathway to accelerate gastric cancer cell growth (2023-11-13)
期刊：BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
DOI：10.1590/1414-431X2023e12943
影响因子 ：2.3
引用产品： MKN-45 细胞 , SNU-1 细胞 , NCI-N87 [N87] 细胞 , AGS 细胞
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A new anthraquinone derivative from the marine fish-derived fungus Alternaria sp. X112 (2023-09-13)
期刊：NATURAL PRODUCT RESEARCH
DOI：10.1080/14786419.2023.2258540
影响因子 ：2.2
引用产品： MCF7 [MCF-7] 细胞 , MKN-45 细胞 , TE-1 细胞 , HCT 116 细胞
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RNA-binding protein ENO1 promotes the tumor progression of gastric cancer by binding to and regulating gastric cancer-related genes (2023-04-17)
期刊：Journal of Gastrointestinal Oncology
影响因子 ：2.1
引用产品： MKN-45 细胞
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Macrophage-derived exosomes regulate gastric cancer cell oxaliplatin resistance by wrapping circ 0008253 (2022-11-23)
期刊：CELL CYCLE
DOI：10.1080/15384101.2022.2146839
影响因子 ：5.2
引用产品： THP-1 细胞 , KATO III [KATO 3] 细胞 , MKN-45 细胞
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CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis (2022-10-03)
期刊：ENVIRONMENTAL TOXICOLOGY
影响因子 ：4.1
引用产品： MKN-45 细胞 , MKN-45细胞专用培养基 , AGS 细胞 , AGS细胞专用培养基 , Hs-746T 细胞 , Hs-746T细胞专用培养基 , NCI-N87 [N87] 细胞 , NCI-N87 [N87]细胞专用培养基 , HGC-27 细胞 , HGC-27细胞专用培养基 , GES-1 细胞 , GES-1细胞专用培养基
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Silencing of Nudix type 5 represses proliferation and invasion and enhances chemosensitivity of gastric carcinoma cells by affecting the AKT/GSK-3β/β-catenin pathway (2003-02-20)
期刊：Toxicology And Applied Pharmacology
DOI：10.1016/j.taap.2022.115968
影响因子 ：3.8
引用产品： SGC-7901 细胞 , HGC-27 细胞 , MKN-45 细胞 , NCI-N87 [N87] 细胞 , GES-1 细胞
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Achaete-scute complex-like 2 regulated inflammatory mechanism through Toll-like receptor 4 activating in stomach adenocarcinoma (2022-08-25)
期刊：World Journal of Surgical Oncology
DOI：10.1186/s12957-022-02722-y
影响因子 ：3.3
引用产品： GES-1 细胞 , AGS 细胞 , SGC-7901 细胞 , MKN-45 细胞 , SNU-1 细胞
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Flavonoid-Rich Extract of Oldenlandia diffusa (Willd.) Roxb. Inhibits Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis (2022-08-31)
期刊：Chinese Journal of Integrative Medicine
影响因子 ：2.6
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Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells (2022-12-08)
期刊：BIOCHEMICAL GENETICS
DOI：10.1007/s10528-022-10309-1
影响因子 ：2.2
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Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer (2022-11-30)
期刊：HISTOLOGY AND HISTOPATHOLOGY
影响因子 ：2.1
引用产品： 特级胎牛血清 , AGS 细胞 , MKN-45 细胞 , NCI-N87 [N87] 细胞 , SNU-1 细胞
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Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis (2004-01-20)
期刊：OncoTargets and Therapy
影响因子 ：4.3
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LncRNA SNHG6 knockdown inhibits cisplatin resistance and progression of gastric cancer through miR-1297/BCL-2 axis (2012-01-20)
期刊：Bioscience Reports
影响因子 ：4.0
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TYMSOS drives the proliferation, migration, and invasion of gastric cancer cells by regulating ZNF703 via sponging miR-4739 (2004-01-20)
期刊：Cell Biology International
影响因子 ：3.9
引用产品： MKN-45 细胞 , MKN-7 [MKN7; MKN 7] 细胞 , GES-1 细胞
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LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p (2006-01-20)
期刊：Bmc Cancer
DOI：10.1186/s12885-021-08227-3
影响因子 ：3.8
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Ubiquitin-specific protease 1 overexpression indicates poor prognosis and promotes proliferation, migration, and invasion of gastric cancer cells (2012-01-20)
期刊：Tissue & Cell
DOI：10.1016/j.tice.2021.101723
影响因子 ：2.6
引用产品： NCI-N87 [N87] 细胞 , AGS 细胞 , MKN-45 细胞 , SNU-1 细胞 , GES-1 细胞
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Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis (2001-01-20)
期刊：Open Life Sciences
影响因子 ：2.2
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Chrysin Induced Cell Apoptosis and Inhibited Invasion Through Regulation of TET1 Expression in Gastric Cancer Cells (2004-00-20)
期刊：OncoTargets and Therapy
影响因子 ：4.0
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Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis (2010-00-20)
期刊：Cancer Management and Research
影响因子 ：3.3
引用产品： MKN-45 细胞 , NCI-N87 [N87] 细胞 , HGC-27 细胞 , AGS 细胞 , RPMI-1640 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , GES-1 细胞
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Long Noncoding RNA SNHG22 Induces Cell Migration, Invasion, and Angiogenesis of Gastric Cancer Cells via microRNA-361-3p/HMGA1/Wnt/β-Catenin Axis (2012-00-20)
期刊：Cancer Management and Research
影响因子 ：3.3
引用产品： KATO III [KATO 3] 细胞 , MKN-45 细胞
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CREB1 Suppresses Transcription of microRNA-186 to Promote Growth, Invasion and Epithelial–Mesenchymal Transition of Gastric Cancer Cells Through the KRT8/HIF-1α Axis (2009-00-20)
期刊：Cancer Management and Research
影响因子 ：3.3
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Long non‑coding RNA lnc‑GNAT1‑1 inhibits gastric cancer cell proliferation and invasion through the Wnt/β‑catenin pathway in Helicobacter pylori infection (2008-08-20)
期刊：Molecular Medicine Reports
影响因子 ：3.4
引用产品： SGC-7901 细胞 , MKN-45 细胞
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