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产品概述
名称 | A-498 (人肾癌细胞) (STR鉴定正确) |
别称 | A498 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | A-498细胞是由Aaronson·S建立,源自一位52岁患有肾癌的女性病人。 |
年龄(性别) | 女性;52岁 |
组织来源 | 肾脏 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肾癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~60 hours |
致瘤性 | Yes, in nude mice; forms undifferentiated carcinoma; also forms tumors in anti thymocyte serum treated newborn mice. |
保藏机构 | ATCC; CRL-7908ATCC; HTB-44 DSMZ; ACC-55 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 26 D3S1358 15 D5S818 11,13 D7S820 10,11 D8S1179 13,15 D13S317 12 D16S539 12 D18S51 17 D19S433 12 D21S11 28,32 FGA 18,20 PentaD 9,14 PentaE 10,14 TH01 6,9.3 TPOX 8,11 vWA 18 D6S1043 11 D12S391 21 D2S441 11,14 -
STR鉴定图
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参考文献
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HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY (2025-01-01)
期刊:International Journal of Biological Sciences
影响因子 :8.2
引用产品: 786-O [786-0] 细胞 , OS-RC-2 细胞 , A-498 细胞 , ACHN 细胞 , Caki-1 细胞 , HK-2 细胞 , 293T [HEK-293T] 细胞
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Hypoxia-triggered ERRα acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion (2025-01-16)
期刊:Cell Death & Disease
DOI:10.1038/s41419-025-07345-1
影响因子 :8.1
引用产品: HK-2 细胞 , ACHN 细胞 , A-498 细胞 , 769-P 细胞 , 786-O [786-0] 细胞 , OS-RC-2 细胞 , 293T [HEK-293T] 细胞
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Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma (2025-01-02)
期刊:Scientific Reports
DOI:10.1038/s41598-024-84834-x
影响因子 :3.8
引用产品: A-498 细胞 , 786-O [786-0] 细胞
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HDAC8 Enhances the Function of HIF-2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC (2024-07-29)
期刊:Advanced Science
影响因子 :14.3
引用产品: A-498 细胞 , 786-O [786-0] 细胞 , ACHN 细胞
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USP7 depletion potentiates HIF2α degradation and inhibits clear cell renal cell carcinoma progression (2024-10-15)
期刊:Cell Death & Disease
DOI:10.1038/s41419-024-07136-0
影响因子 :8.1
引用产品: Caki-2 细胞 , A-498 细胞 , OS-RC-2 细胞 , 786-O [786-0] 细胞
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PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC (2024-10-23)
期刊:ONCOGENE
DOI:10.1038/s41388-024-03198-8
影响因子 :6.9
引用产品: Ham's F-12K 培养基 , A-498 细胞 , HUV-EC-C [HUVEC] 细胞
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A multifunctional antibody fusion protein 57103 targeting CD24, IL-4R, and αvβ3 for treating cancer and regulating the tumor microenvironment (2024-05-17)
期刊:BIOMEDICINE & PHARMACOTHERAPY
DOI:10.1016/j.biopha.2024.116714
影响因子 :6.9
引用产品: 786-O [786-0] 细胞 , A-498 细胞 , OS-RC-2 细胞 , Caki-2 细胞
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CDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and increase the sensitivity of ccRCC to mTOR inhibitors (2024-06-18)
期刊:BRITISH JOURNAL OF CANCER
DOI:10.1038/s41416-024-02750-3
影响因子 :6.4
引用产品: A-498 细胞 , HUV-EC-C [HUVEC] 细胞
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Disulfideptosis-associated lncRNAs reveal features of prognostic, immune escape, tumor mutation, and tumor malignant progression in renal clear cell carcinoma (2024-02-08)
期刊:Aging-US
影响因子 :5.2
引用产品: 786-O [786-0] 细胞 , OS-RC-2 细胞 , A-498 细胞 , ACHN 细胞 , HK-2 细胞
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Human leukocyte antigen DR alpha inhibits renal cell carcinoma progression by promoting the polarization of M2 macrophages to M1 via the NF-κB pathway (2024-12-03)
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2024.113706
影响因子 :4.8
引用产品: A-498 细胞 , THP-1 细胞 , RAW 264.7 细胞
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Improved Immunotherapy Outcomes via Cuproptosis Upregulation of HLA-DRA Expression: Promoting the Aggregation of CD4+ and CD8+T Lymphocytes in Clear Cell Renal Cell Carcinoma (2024-05-24)
期刊:Pharmaceuticals
影响因子 :4.3
引用产品: 786-O [786-0] 细胞 , OS-RC-2 细胞 , A-498 细胞 , HK-2 细胞 , Renca [RenCa] 细胞
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Disruption of Autophagic Flux and Treatment with the PDPK1 Inhibitor GSK2334470 Synergistically Inhibit Renal Cell Carcinoma Pathogenesis (2024-01-20)
期刊:Journal of Cancer
影响因子 :3.9
引用产品: 786-O [786-0] 细胞 , A-498 细胞 , HK-2 细胞
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SLC11A1 promotes kidney renal clear cell carcinoma (KIRC) progression by remodeling the tumor microenvironment (2024-05-16)
期刊:TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI:10.1016/j.taap.2024.116975
影响因子 :3.8
引用产品: 786-O [786-0] 细胞 , SW839 细胞 , A-498 细胞 , HK-2 细胞 , OS-RC-2 细胞 , THP-1 细胞
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Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC (2024-03-21)
期刊:GENE
DOI:10.1016/j.gene.2024.148403
影响因子 :3.5
引用产品: HK-2 细胞 , ACHN 细胞 , A-498 细胞 , 786-O [786-0] 细胞 , OS-RC-2 细胞 , Caki-1 细胞 , RPMI-1640 培养基 , MEM 培养基
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ZBP1 as a prognostic biomarker correlated with cell proliferation in clear cell renal cell carcinoma (2024-10-10)
期刊:Heliyon
DOI:10.1016/j.heliyon.2024.e39267
影响因子 :3.4
引用产品: 786-O [786-0] 细胞 , A-498 细胞 , HK-2 细胞 , ACHN 细胞 , 769-P 细胞
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DLX5 Promotes Radioresistance in Renal Cell Carcinoma by Upregulating c-Myc Expression (2024-11-26)
期刊:Frontiers in Bioscience-Landmark
影响因子 :3.3
引用产品: 特级胎牛血清 , McCoy's 5A 培养基 , A-498 细胞 , MEM(含NEAA) 培养基 , 786-O [786-0] 细胞 , 青霉素-链霉素溶液(双抗),100× , Caki-1 细胞 , RPMI-1640 培养基 , HK-2 细胞
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Decreased expression of TXNIP is associated with poor prognosis and immune infiltration in kidney renal clear cell carcinoma (2024-01-12)
期刊:Oncology Letters
影响因子 :2.9
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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis (2024-05-11)
期刊:Discover Oncology
DOI:10.1007/s12672-024-01018-9
影响因子 :2.2
引用产品: A-498 细胞 , Caki-2 细胞 , Caki-1 细胞 , 769-P 细胞 , 293 [HEK-293] 细胞 , OS-RC-2 细胞 , 786-O [786-0] 细胞
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Integration of bulk RNA-seq and single-cell RNA-seq constructs: a cancer-associated fibroblasts-related signature to predict prognosis and therapeutic response in clear cell renal cell carcinoma. (2024-04-15)
期刊:American Journal of Translational Research
影响因子 :2.2
引用产品: HK-2 细胞 , A-498 细胞 , 786-O [786-0] 细胞
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CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p (2024-05-19)
期刊:GENESIS
影响因子 :1.5
引用产品: 786-O [786-0] 细胞 , McCoy's 5A 培养基 , DMEM高糖 培养基 , A-498 细胞 , HK-2 细胞 , RPMI-1640 培养基 , 769-P 细胞 , Caki-1 细胞
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RNF26 up-regulates PD-L1 to regulate the cancer immune response in ccRCC (2024-09-04)
期刊:BIOCELL
DOI:10.32604/biocell.2024.051747
影响因子 :0.8
引用产品: Renca [RenCa] 细胞 , MEM(ATCC改良) 培养基 , A-498 细胞 , Renca [RenCa]细胞专用培养基
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ZDHHC2-mediated AGK palmitoylation activates AKT/mTOR signaling to reduce sunitinib sensitivity in renal cell carcinoma (2023-04-20)
期刊:CANCER RESEARCH
DOI:10.1158/0008-5472.CAN-22-3105
影响因子 :11.2
引用产品: A-498 细胞 , MEM (含NEAA) 培养基 , Annexin V-FITC染色液
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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming (2023-02-20)
期刊:Cell Death & Disease
DOI:10.1038/s41419-023-05677-4
影响因子 :9.0
引用产品: A-498 细胞 , ACHN 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞
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The E3 ligase RBCK1 reduces the sensitivity of ccRCC to sunitinib through the ANKRD35-MITD1-ANXA1 axis (2023-02-02)
期刊:ONCOGENE
DOI:10.1038/s41388-023-02613-w
影响因子 :8.0
引用产品: 786-O [786-0] 细胞 , A-498 细胞 , STR鉴定 , MEM (含NEAA) 培养基
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Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma (2023-08-26)
期刊:Computational and Structural Biotechnology Journal
DOI:10.1016/j.csbj.2023.08.023
影响因子 :6.0
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , A-498 细胞 , HK-2 细胞
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Focusing on the Abnormal Events of NPC1, NPC2, and NPC1L1 in Pan-Cancer and Further Constructing LUAD and KICH Prediction Models (2023-12-18)
期刊:JOURNAL OF PROTEOME RESEARCH
DOI:10.1021/acs.jproteome.3c00655
影响因子 :4.4
引用产品: A549 [A-549] 细胞 , NCI-H1299 细胞 , HK-2 细胞 , A-498 细胞 , MEM 培养基 , RPMI-1640 培养基 , Ham's F-12K 培养基
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Construction and Validation of a Novel Cuproptosis-Related Seven-lncRNA Signature to Predict the Outcomes, Immunotherapeutic Responses, and Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma (2023-01-25)
期刊:DISEASE MARKERS
影响因子 :3.5
引用产品: A-498 细胞 , OS-RC-2 细胞
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YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway (2022-08-17)
期刊:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI:10.1186/s13046-022-02460-9
影响因子 :12.7
引用产品: 786-O [786-0] 细胞 , A-498 细胞 , STR鉴定 , MEM (含NEAA) 培养基
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Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma (2022-09-30)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2022.1021935
影响因子 :8.8
引用产品: ACHN 细胞 , HK-2 细胞 , Caki-2 细胞 , A-498 细胞 , Caki-1 细胞 , 786-O [786-0] 细胞 , OS-RC-2 细胞 , 769-P 细胞
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WT1 Inhibits Human Renal Carcinoma Cell Proliferation and Induces G2/M Arrest by Upregulating IL-24 Expression (2022-07-23)
期刊:Biomed Research International
影响因子 :3.2
引用产品: A-498 细胞
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Identification of a combined lncRNA prognostic signature and knockdown of lncRNA MANCR to inhibit progression of clear cell renal cell carcinoma by bioinformatics analysis (2022-09-01)
期刊:Translational Andrology and Urology
影响因子 :2.5
引用产品: A-498 细胞 , ACHN 细胞 , SN12C 细胞 , 786-O [786-0] 细胞 , 769-P 细胞
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RRM2 Regulates Sensitivity to Sunitinib and PD-1 Blockade in Renal Cancer by Stabilizing ANXA1 and Activating the AKT Pathway (2021-07-28)
期刊:Advanced Science
影响因子 :15.1
引用产品: 786-O [786-0] 细胞 , A-498 细胞 , Renca [RenCa] 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗),100× , MEM (含NEAA) 培养基 , Renca [RenCa]细胞专用培养基
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Deubiquitylation and stabilization of ARMC5 by ubiquitin-specific processing protease 7 (USP7) are critical for RCC proliferation (2021-02-05)
期刊:JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子 :5.3
引用产品: 786-O [786-0] 细胞 , 769-P 细胞 , A-498 细胞 , ACHN 细胞 , 293T [HEK-293T] 细胞
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The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi-omics study (2021-11-10)
期刊:Cancer Medicine
影响因子 :4.0
引用产品: 786-O [786-0] 细胞 , A-498 细胞 , HK-2 细胞
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HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma (2021-02-19)
期刊:Cell Biology International
影响因子 :3.9
引用产品: HK-2 细胞 , A-498 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞
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Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma (2021-09-20)
期刊:Pathology Research And Practice
影响因子 :3.3
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APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells (2021-03-17)
期刊:IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
DOI:10.1007/s11626-021-00589-z
影响因子 :2.1
引用产品: 293T [HEK-293T] 细胞 , 786-O [786-0] 细胞 , A-498 细胞
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Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55 (2020-12-01)
期刊:Journal Of Experimental & Clinical Cancer Research
DOI:10.1186/s13046-020-01744-2
影响因子 :11.3
引用产品: A-498 细胞 , Caki-1 细胞 , Caki-2 细胞 , 786-O [786-0] 细胞
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RETRACTED ARTICLE: Silencing circular RNA-ZNF652 represses proliferation and EMT process of renal carcinoma cells via raising miR-205 (2020-02-19)
期刊:Artificial Cells Nanomedicine and Biotechnology
DOI:10.1080/21691401.2020.1725532
影响因子 :5.8
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δ‐Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β‐catenin nuclear localization and activating its downstream target genes (2020-01-28)
期刊:Cancer Medicine
影响因子 :4.0
引用产品: HK-2 细胞 , A-498 细胞 , ACHN 细胞 , 786-O [786-0] 细胞
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Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma (2020-05-22)
期刊:JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI:10.1007/s00432-020-03259-x
影响因子 :3.6
引用产品: 786-O [786-0] 细胞 , Caki-1 细胞 , A-498 细胞 , HK-2 细胞
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