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产品概述
名称 | Caki-1 (人肾透明细胞癌皮肤转移细胞) (STR鉴定正确) |
别称 | CAKI-1; CaKi-1; caki-1; CAKI.1; CAKI 1; CAKI1; Caki1 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | Caki-1细胞的超微结构中包含许多微绒毛、少许微丝、许多小线粒体、充分发育的高尔基体、内质网、许多脂滴和多层体,次级溶酶体;目前,没有在Caki-1细胞内发现病毒颗粒。 |
年龄(性别) | 男性;49岁 |
组织来源 | 肾透明细胞癌皮肤转移 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肾癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~40-60 hours |
致瘤性 | Yes, in nude mice; forms clear cell carcinoma in nude mice consistent with renal primary; also forms tumors in steroid treated hamsters. |
抗原表达情况 | Blood Type O; Rh-; HLA A9, B12, Bw35 |
保藏机构 | ATCC; HTB-46 DSMZ; ACC-142DSMZ; ACC-731 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,11 D2S1338 17,19 D3S1358 17 D5S818 11,12 D7S820 8,12 D8S1179 12,14 D13S317 11,12 D16S539 12 D18S51 14 D19S433 14 D21S11 28,30 FGA 26 PentaD 11,12 PentaE 11,22 TH01 6,8 TPOX 8,11 vWA 15,17 D6S1043 11,12 D12S391 15,17 D2S441 12,14 -
STR鉴定图
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参考文献
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TRIM65 promotes renal cell carcinoma through ubiquitination and degradation of BTG3 (2024-05-22)
期刊:Cell Death & Disease
DOI:10.1038/s41419-024-06741-3
影响因子 :9.0
引用产品: DMEM高糖 培养基 , McCoy's 5A 培养基 , MEM 培养基 , ACHN 细胞 , Caki-2 细胞 , RPMI-1640 培养基 , Caki-1 细胞 , 769-P 细胞
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Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells (2024-03-30)
期刊:APOPTOSIS
DOI:10.1007/s10495-024-01953-6
影响因子 :7.2
引用产品: HK-2 细胞 , Caki-1 细胞 , 769-P 细胞 , 786-O [786-0] 细胞 , SW839 细胞
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CLIP170 enhancing FOSL1 expression via attenuating ubiquitin-mediated degradation of β-catenin drives renal cell carcinoma progression (2024-11-28)
期刊:CELLULAR AND MOLECULAR LIFE SCIENCES
DOI:10.1007/s00018-024-05504-9
影响因子 :6.2
引用产品: 786-O [786-0] 细胞 , Caki-1 细胞 , 769-P 细胞 , HK-2 细胞 , ACHN 细胞
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Selective expansion of renal cancer stem cells using microfluidic single-cell culture arrays for anticancer drug testing (2024-02-01)
期刊:LAB ON A CHIP
影响因子 :6.1
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , ACHN 细胞
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Disulfidptosis-associated LncRNA signature predicts prognosis and immune response in kidney renal clear cell carcinoma (2024-08-22)
期刊:Biology Direct
DOI:10.1186/s13062-024-00517-7
影响因子 :5.7
引用产品: 786-O [786-0] 细胞 , Caki-1 细胞 , HK-2 细胞
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TFE3-SLC36A1 axis promotes resistance to glucose starvation in kidney cancer cells (2024-04-08)
期刊:JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 :4.8
引用产品: ACHN 细胞 , DMEM无糖 培养基 , McCoy's 5A 培养基 , McCoy's 5A无糖 培养基 , MEM无糖(含NEAA) 培养基 , MEM(含NEAA) 培养基 , Caki-1 细胞
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Low ACADM expression predicts poor prognosis and suppressive tumor microenvironment in clear cell renal cell carcinoma (2024-04-25)
期刊:Scientific Reports
DOI:10.1038/s41598-024-59746-5
影响因子 :4.6
引用产品: RPMI-1640 培养基 , 786-O [786-0] 细胞 , ACHN 细胞 , 769-P 细胞 , HK-2 细胞 , Caki-1 细胞 , McCoy's 5A 培养基 , MEM(含NEAA) 培养基
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Crosstalk between GBP2 and M2 macrophage promotes the ccRCC progression (2024-09-02)
期刊:CANCER SCIENCE
影响因子 :4.5
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , THP-1 细胞
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Crosstalk of disulfidptosis-related subtypes identifying a prognostic signature to improve prognosis and immunotherapy responses of clear cell renal cell carcinoma patients (2024-04-26)
期刊:BMC GENOMICS
DOI:10.1186/s12864-024-10307-0
影响因子 :4.4
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , HK-2 细胞 , ACHN 细胞
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Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC (2024-03-21)
期刊:GENE
DOI:10.1016/j.gene.2024.148403
影响因子 :3.5
引用产品: HK-2 细胞 , ACHN 细胞 , A-498 细胞 , 786-O [786-0] 细胞 , OS-RC-2 细胞 , Caki-1 细胞 , RPMI-1640 培养基 , MEM 培养基
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DLX5 Promotes Radioresistance in Renal Cell Carcinoma by Upregulating c-Myc Expression (2024-11-26)
期刊:Frontiers in Bioscience-Landmark
影响因子 :3.3
引用产品: 特级胎牛血清 , McCoy's 5A 培养基 , A-498 细胞 , MEM(含NEAA) 培养基 , 786-O [786-0] 细胞 , 青霉素-链霉素溶液(双抗),100× , Caki-1 细胞 , RPMI-1640 培养基 , HK-2 细胞
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KAT7 Suppresses Tumorigenesis in Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating Cell Cycle and Ferroptosis Sensitivity (2024-07-02)
期刊:EXPERIMENTAL CELL RESEARCH
DOI:10.1016/j.yexcr.2024.114149
影响因子 :3.3
引用产品: ACHN 细胞 , Caki-1 细胞 , 786-O [786-0] 细胞 , Caki-2 细胞
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Centromere protein K enhances the activation of YAP1/TAZ signal cascade to drive the progression of clear cell renal cell carcinoma (2024-11-29)
期刊:TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI:10.1016/j.taap.2024.117181
影响因子 :3.3
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , Caki-2 细胞 , HK-2 细胞 , 769-P 细胞
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ETS homologous factor, controlled by lysine-specific demethylase 5B, suppresses clear cell renal cell carcinoma by inducing Filamin-B (2024-06-14)
期刊:GENE
DOI:10.1016/j.gene.2024.148702
影响因子 :2.6
引用产品: OS-RC-2 细胞 , Caki-1 细胞 , HK-2 细胞 , THP-1 细胞
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PLAUR facilitates the progression of clear cell renal cell carcinoma by activating the PI3K/AKT/mTOR signaling pathway (2024-06-27)
期刊:PeerJ
影响因子 :2.3
引用产品: Caki-1 细胞 , ACHN 细胞 , 769-P 细胞 , 786-O [786-0] 细胞 , 293 [HEK-293] 细胞
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Elevated histone deacetylase 10 expression promotes the progression of clear cell renal cell carcinoma by Notch-1-PTEN signaling axis (2024-05-11)
期刊:Discover Oncology
DOI:10.1007/s12672-024-01018-9
影响因子 :2.2
引用产品: A-498 细胞 , Caki-2 细胞 , Caki-1 细胞 , 769-P 细胞 , 293 [HEK-293] 细胞 , OS-RC-2 细胞 , 786-O [786-0] 细胞
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Integrative bioinformatics and in vitro exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma (2024-10-16)
期刊:ONCOLOGY RESEARCH
影响因子 :2.0
引用产品: Caki-1 细胞 , OS-RC-2 细胞 , ACHN 细胞 , HK-2 细胞 , 786-O [786-0] 细胞
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CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p (2024-05-19)
期刊:GENESIS
影响因子 :1.5
引用产品: 786-O [786-0] 细胞 , McCoy's 5A 培养基 , DMEM高糖 培养基 , A-498 细胞 , HK-2 细胞 , RPMI-1640 培养基 , 769-P 细胞 , Caki-1 细胞
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Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming (2023-02-20)
期刊:Cell Death & Disease
DOI:10.1038/s41419-023-05677-4
影响因子 :9.0
引用产品: A-498 细胞 , ACHN 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞
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Identification of the H3K36me3 reader LEDGF/p75 in the pancancer landscape and functional exploration in clear cell renal cell carcinoma (2023-08-26)
期刊:Computational and Structural Biotechnology Journal
DOI:10.1016/j.csbj.2023.08.023
影响因子 :6.0
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , A-498 细胞 , HK-2 细胞
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Establishing a prognostic model based on five starvation-related long non-coding RNAs for clear cell renal cell carcinoma (2023-06-20)
期刊:Aging-US
影响因子 :5.2
引用产品: 786-O [786-0] 细胞 , Caki-1 细胞 , HK-2 细胞
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LncRNA-encoded Micropeptide ACLY?-?BP drives lipid deposition and cell proliferation in Clear Cell Renal Cell Carcinoma via maintenance of ACLY acetylation (2023-07-06)
期刊:MOLECULAR CANCER RESEARCH
DOI:10.1158/1541-7786.MCR-22-0781
影响因子 :5.2
引用产品: 786-O [786-0] 细胞 , 293T [HEK-293T] 细胞 , ACHN 细胞 , Caki-1 细胞
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Identification of the regulatory mechanism of ACE2 in COVID-19–induced kidney damage with systems genetics approach (2023-03-23)
期刊:JOURNAL OF MOLECULAR MEDICINE-JMM
DOI:10.1007/s00109-023-02304-9
影响因子 :4.7
引用产品: Caki-1 细胞
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A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance (2023-04-08)
期刊:Scientific Reports
DOI:10.1038/s41598-023-27975-9
影响因子 :4.6
引用产品: HK-2 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞 , SV-HUC-1 细胞 , T24 [T-24] 细胞 , 5637 细胞 , RWPE-1 细胞 , PC-3 细胞 , DU 145 细胞 , DMEM高糖 培养基 , RPMI-1640 培养基 , Ham's F-12K 培养基 , 人前列腺上皮细胞完全培养基
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Based on disulfidptosis, revealing the prognostic and immunological characteristics of renal cell carcinoma with tumor thrombus of vena cava and identifying potential therapeutic target AJAP1 (2023-05-29)
期刊:JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI:10.1007/s00432-023-04877-x
影响因子 :3.6
引用产品: HK-2 细胞 , Caki-1 细胞 , OS-RC-2 细胞
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P4HA3 promotes clear cell renal cell carcinoma progression via the PI3K/AKT/GSK3β pathway (2023-01-02)
期刊:MEDICAL ONCOLOGY
DOI:10.1007/s12032-022-01926-2
影响因子 :3.4
引用产品: OS-RC-2 细胞 , 786-O [786-0] 细胞 , ACHN 细胞 , 769-P 细胞 , Caki-1 细胞
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RUNX1 predicts poor prognosis and correlates with tumor progression in clear cell renal carcinoma (2023-10-12)
期刊:PATHOLOGY RESEARCH AND PRACTICE
影响因子 :2.8
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , 青霉素-链霉素溶液 (双抗),100×
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TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression (2023-10-30)
期刊:PeerJ
影响因子 :2.7
引用产品: 786-O [786-0] 细胞 , Caki-1 细胞
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Crosstalk of necroptosis and pyroptosis defines tumor microenvironment characterization and predicts prognosis in clear cell renal carcinoma (2022-09-30)
期刊:Frontiers in Immunology
DOI:10.3389/fimmu.2022.1021935
影响因子 :8.8
引用产品: ACHN 细胞 , HK-2 细胞 , Caki-2 细胞 , A-498 细胞 , Caki-1 细胞 , 786-O [786-0] 细胞 , OS-RC-2 细胞 , 769-P 细胞
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Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis (2022-12-25)
期刊:Cancers
影响因子 :6.6
引用产品: 786-O [786-0] 细胞 , ACHN 细胞 , Caki-1 细胞 , 769-P 细胞 , HK-2 细胞
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Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis. (2022-09-21)
期刊:Frontiers in Pharmacology
影响因子 :6.0
引用产品: SV-HUC-1 细胞 , T24 [T-24] 细胞 , 5637 细胞 , HK-2 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞 , RWPE-1 细胞 , PC-3 细胞 , DU 145 细胞 , Ham's F-12K 培养基 , DMEM高糖 培养基 , 人前列腺上皮细胞完全培养基 , RPMI-1640 培养基
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Spindle pole body component 24 homolog potentiates tumor progression via regulation of SRY-box transcription factor 2 in clear cell renal cell carcinoma (2022-01-14)
期刊:Faseb Journal
影响因子 :4.8
引用产品: OS-RC-2 细胞 , Caki-1 细胞
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Pan-Cancer Transcriptomic Analysis Identifies PLK1 Crucial for the Tumorigenesis of Clear Cell Renal Cell Carcinoma (2022-02-16)
期刊:Journal of Inflammation Research
影响因子 :4.5
引用产品: Caki-1 细胞 , 769-P 细胞 , 786-O [786-0] 细胞 , ACHN 细胞 , HK-2 细胞
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Upregulation of Metallothionein 1?G (MT1G) Negatively Regulates Ferroptosis in Clear Cell Renal Cell Carcinoma by Reducing Glutathione Consumption (2022-09-27)
期刊:Journal of Oncology
影响因子 :4.5
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The potential of Lycium barbarum miR166a in kidney cancer treatment (2022-12-28)
期刊:EXPERIMENTAL CELL RESEARCH
DOI:10.1016/j.yexcr.2022.113455
影响因子 :4.2
引用产品: Caki-1 细胞 , ACHN 细胞 , McCoy's 5A 培养基 , DMEM高糖 培养基
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HOXD1 functions as a novel tumor suppressor in kidney renal clear cell carcinoma (2021-02-19)
期刊:Cell Biology International
影响因子 :3.9
引用产品: HK-2 细胞 , A-498 细胞 , 786-O [786-0] 细胞 , Caki-1 细胞
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Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55 (2020-12-01)
期刊:Journal Of Experimental & Clinical Cancer Research
DOI:10.1186/s13046-020-01744-2
影响因子 :11.3
引用产品: A-498 细胞 , Caki-1 细胞 , Caki-2 细胞 , 786-O [786-0] 细胞
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Comprehensive analysis of the HOXA gene family identifes HOXA13as a novel oncogenic gene in kidney renal clear cell carcinoma (2020-05-22)
期刊:JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
DOI:10.1007/s00432-020-03259-x
影响因子 :3.6
引用产品: 786-O [786-0] 细胞 , Caki-1 细胞 , A-498 细胞 , HK-2 细胞
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Sertraline/ICG‐loaded liposome for dual‐modality imaging and effective chemo‐photothermal combination therapy against metastatic clear cell renal cell carcinoma (2020-01-14)
期刊:Chemical Biology & Drug Design
影响因子 :3.0
引用产品: Caki-1 细胞
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LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p (2019-11-21)
期刊:Cancer Cell International
影响因子 :5.8
引用产品: Caki-1 细胞 , 786-O [786-0] 细胞 , 769-P 细胞 , 293T [HEK-293T] 细胞 , Caki-1细胞专用培养基 , 786-O [786-0]细胞专用培养基 , 769-P细胞专用培养基 , 293T [HEK-293T]细胞专用培养基
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