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产品概述
| 名称 | C2C12 (小鼠成肌细胞) (STR鉴定正确) |
| 别称 | C2c12; C2-C12; C12 |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成肌细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 该细胞贴壁松散，操作时请尽量轻柔；换液时需预热培养基；收货如有大块脱落的细胞团，为正常现象，请按照收货注意事项处理。 |
| 背景描述 | C2C12细胞是由D·Yaffe和O·Saxel建立的小鼠成肌细胞株的亚克隆；C2C12细胞分化很快，形成可伸缩的肌管并生成特征性的肌蛋白。用骨形成蛋白2(BMP-2)处理C2C12细胞，会导致C2C12细胞的分化途径从成肌细胞转换为成骨细胞。检测表明，C2C12细胞肢骨发育畸形病毒(鼠痘)阴性。 |
| 年龄（性别） | 不详 |
| 组织来源 | 骨骼肌；品系：C3H |
| 细胞类型 | 自发永生化细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~20 hours |
| 保藏机构 | ATCC; CRL-1772 BCRC; 60083 BCRJ; 0058 DSMZ; ACC-565 |
STR鉴定
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STR位点信息
18-3 16 6-7 12 5-5 15 X-1 25,26 1-2 16 7-1 26 8-1 17 1-1 10 19-2 12 15-3 25.3 12-1 16 6-4 18 4-2 19.3 3-2 14 2-1 9 13-1 17.1
11-2 16 17-2 15 -
STR鉴定图
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参考文献
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Di-PEGylated insulin: A long-acting insulin conjugate with superior safety in reducing hypoglycemic events (2024-03-04)
期刊：Acta Pharmaceutica Sinica B
DOI：10.1016/j.apsb.2024.02.022
影响因子 ：14.5
引用产品： C2C12 细胞
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Development of a tannic acid and silicate ions functionalized PVA-starch composite hydrogel for in situ skeletal muscle repairing (2024-03-13)
期刊：Journal of Materials Chemistry B
影响因子 ：7.0
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RNA Sequencing Reveals the Inhibitory Effect of High Levels of Arachidonic Acid and Linoleic Acid on C2C12 Differentiation and Myogenic Biomarkers (2024-02-29)
期刊：Nutrients
影响因子 ：5.9
引用产品： C2C12 细胞
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Folic acid promotes myoblast migration through Folr1 interacting with RhoA and improves skeletal muscle regeneration (2024-01-05)
期刊：Journal of Functional Foods
影响因子 ：5.6
引用产品： C2C12 细胞
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Selenium Nanoparticles Attenuate Cobalt Nanoparticle-Induced Skeletal Muscle Injury: A Study Based on Myoblasts and Zebrafish (2024-02-06)
期刊：Toxics
影响因子 ：4.6
引用产品： C2C12 细胞
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Uncovering the potential molecular mechanism of liraglutide to alleviate the effects of high glucose on myoblasts based on high-throughput transcriptome sequencing technique (2024-02-08)
期刊：BMC GENOMICS
DOI：10.1186/s12864-024-10076-w
影响因子 ：4.4
引用产品： C2C12 细胞
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Lactate ameliorates palmitate-induced impairment of differentiative capacity in C2C12 cells through the activation of voltage-gated calcium channels (2024-02-19)
期刊：JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
DOI：10.1007/s13105-024-01009-y
影响因子 ：3.4
引用产品： C2C12 细胞
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Ketogenic diet ameliorates high-fat diet-induced insulin resistance in mouse skeletal muscle by alleviating endoplasmic reticulum stress (2024-02-05)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2024.149559
影响因子 ：3.1
引用产品： C2C12 细胞
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Lactate induces C2C12 myoblasts differentiation by mediating ROS/p38 MAPK signalling pathway (2024-02-12)
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2024.102324
影响因子 ：2.6
引用产品： C2C12 细胞
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MOFs-Based Nanoagents Enable Sequential Damage to Cancer-Associated Fibroblast and Tumor Cells for Phototriggered Tumor Microenvironment Regulation (2023-08-31)
期刊：Small
影响因子 ：13.3
引用产品： 4T1 细胞 , NIH/3T3 细胞 , C2C12 细胞
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Cordycepin inhibits myogenesis via activating the ERK1/2 MAPK signalling pathway in C2C12 cells (2023-07-14)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2023.115163
影响因子 ：7.5
引用产品： C2C12 细胞
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TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis (2023-02-24)
期刊：Cell Death Discovery
DOI：10.1038/s41420-023-01365-6
影响因子 ：7.0
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Enrichment of miR-17-5p enhances the protective effects of EPC-EXs on vascular and skeletal muscle injury in a diabetic hind limb ischemia model (2023-04-01)
期刊：BIOLOGICAL RESEARCH
DOI：10.1186/s40659-023-00418-5
影响因子 ：6.7
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Effect of manganese ion doping on magnetic properties and magnetic induction heating of Zn-Al ferrite nanoparticles (2023-07-31)
期刊：JOURNAL OF ALLOYS AND COMPOUNDS
DOI：10.1016/j.jallcom.2023.171597
影响因子 ：6.2
引用产品： 293T [HEK-293T] 细胞 , C2C12 细胞 , NIH/3T3 细胞
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Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3 (2023-07-17)
期刊：LIFE SCIENCES
影响因子 ：6.1
引用产品： C2C12 细胞 , DMEM高糖 培养基 , 马血清
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Reduced energy metabolism contributing to aging of skeletal muscle by serum metabolomics and gut microbiota analysis (2023-03-23)
期刊：LIFE SCIENCES
影响因子 ：6.1
引用产品： C2C12 细胞 , C2C12细胞专用培养基
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Vitamin A Promotes the Repair of Mice Skeletal Muscle Injury through RARα (2023-08-22)
期刊：Nutrients
影响因子 ：5.9
引用产品： C2C12 细胞
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GSDMD Knockout Alleviates Sepsis-Associated Skeletal Muscle Atrophy by Inhibiting IL18/AMPK Signaling (2023-06-22)
期刊：iScience
影响因子 ：5.8
引用产品： C2C12 细胞
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Muscle-targeted nanoparticles strengthen the effects of small-molecule inhibitors in ameliorating sarcopenia (2023-11-01)
期刊：Nanomedicine
影响因子 ：5.5
引用产品： C2C12 细胞
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Expression and electrophysiological characteristics of VGSC during mouse myoblasts differentiation (2023-11-13)
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2023.110970
影响因子 ：4.8
引用产品： DMEM高糖 培养基 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , C2C12 细胞
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Proteoglycan Extracted from Ganoderma lucidum Ameliorated Diabetes-Induced Muscle Atrophy via the AMPK/SIRT1 Pathway In Vivo and In Vitro (2023-08-08)
期刊：ACS Omega
影响因子 ：4.1
引用产品： C2C12 细胞
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Antagonizing Effects of Chromium Against Iron-Decreased Glucose Uptake by Regulating ROS-Mediated PI3K/Akt/GLUT4 Signaling Pathway in C2C12 (2023-05-08)
期刊：BIOLOGICAL TRACE ELEMENT RESEARCH
DOI：10.1007/s12011-023-03695-z
影响因子 ：3.9
引用产品： C2C12 细胞 , 青霉素-链霉素溶液 (双抗)，100×
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Resveratrol improves palmitic acid‑induced insulin resistance via the DDIT4/mTOR pathway in C2C12 cells (2023-08-09)
期刊：Molecular Medicine Reports
影响因子 ：3.4
引用产品： C2C12 细胞
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LncRNA XLOC_015548 affects the proliferation and differentiation of myoblasts via the MAPK signaling pathway (2023-02-27)
期刊：EXPERIMENTAL BIOLOGY AND MEDICINE
影响因子 ：3.2
引用产品： C2C12 细胞
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ZnO/glass-based SAW tweezer for dexterous particle patterning and patterned cell culturing (2023-05-04)
期刊：Microfluidics and Nanofluidics
DOI：10.1007/s10404-023-02646-3
影响因子 ：2.8
引用产品： C2C12 细胞
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Epigenome-wide DNA methylation analysis of myasthenia gravis (2023-05-31)
期刊：FEBS Open Bio
影响因子 ：2.6
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Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo (2002-02-20)
期刊：Nature Biotechnology
DOI：10.1038/s41587-021-01180-3
影响因子 ：68.2
引用产品： C2C12 细胞
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Nanoparticle-Stabilized Emulsion Bioink for Digital Light Processing Based 3D Bioprinting of Porous Tissue Constructs (2003-02-20)
期刊：Advanced Healthcare Materials
影响因子 ：11.1
引用产品： NIH/3T3 细胞 , C2C12 细胞 , SK-Hep-1 细胞
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miR-34a Regulates Lipid Droplet Deposition in 3T3-L1 and C2C12 Cells by Targeting LEF1 (2022-12-30)
期刊：Cells
影响因子 ：7.7
引用产品： 3T3-L1 细胞 , C2C12 细胞 , 293 [HEK-293] 细胞
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Development of Probiotic-Fermented Black Mulberry (Morus nigra L.) Juice and Its Antioxidant Activity in C2C12 Cells (2022-12-01)
期刊：Fermentation-Basel
DOI：10.3390/fermentation8120697
影响因子 ：5.1
引用产品： C2C12 细胞
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MicroRNA transcriptome of skeletal muscle during yak development reveals that miR-652 regulates myoblasts differentiation and survival by targeting ISL1 (2022-08-27)
期刊：Journal of Integrative Agriculture
影响因子 ：4.4
引用产品： C2C12 细胞
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Spiroganodermaines A−G from Ganoderma species and their activities against insulin resistance and renal fibrosis (2022-08-02)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2022.113324
影响因子 ：4.0
引用产品： C2C12 细胞
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Meroterpenoids containing benzopyran or benzofuran motif from Ganoderma cochlear (2004-02-20)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2022.113184
影响因子 ：3.8
引用产品： C2C12 细胞
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Structural characterization of minor optically pure and impure meroterpenoid-type compounds in Ganoderma lucidum and structure revision of spirolingzhine D (2022-09-17)
期刊：TETRAHEDRON
影响因子 ：2.4
引用产品： C2C12 细胞
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Polystyrene microplastics-induced ROS overproduction disrupts the skeletal muscle regeneration by converting myoblasts into adipocytes (2004-01-20)
期刊：Journal Of Hazardous Materials
DOI：10.1016/j.jhazmat.2021.125962
影响因子 ：13.6
引用产品： C2C12 细胞
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Near-infrared triggered ropivacaine liposomal gel for adjustable and prolonged local anaesthesia (2011-01-20)
期刊：International Journal Of Pharmaceutics
DOI：10.1016/j.ijpharm.2021.121315
影响因子 ：6.5
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Direct determination of E and Z configurations for double bond in bioactive meroterpenoids from Ganoderma mushrooms by diagnostic 1H NMR chemical shifts and structure revisions of previous analogues (2009-01-20)
期刊：Journal of Functional Foods
影响因子 ：5.6
引用产品： C2C12 细胞
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Meroterpenoids From Ganoderma lucidum Mushrooms and Their Biological Roles in Insulin Resistance and Triple-Negative Breast Cancer (2011-01-20)
期刊：Frontiers in Chemistry
影响因子 ：5.5
引用产品： C2C12 细胞
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Aerobic exercise and resistance exercise alleviate skeletal muscle atrophy through IGF-1/IGF-1R-PI3K/Akt pathway in mice with myocardial infarction (2012-01-20)
期刊：American Journal Of Physiology-Cell Physiology
DOI：10.1152/ajpcell.00344.2021
影响因子 ：5.5
引用产品： C2C12 细胞
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BMSC-Derived Exosomes Inhibit Dexamethasone-Induced Muscle Atrophy via the miR-486-5p/FoxO1 Axis (2010-01-20)
期刊：Frontiers in Endocrinology
影响因子 ：5.2
引用产品： C2C12 细胞
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Transcription factor EB enhances autophagy and ameliorates palmitate-induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells (2010-01-20)
期刊：Clinical And Experimental Pharmacology And Physiology
影响因子 ：2.9
引用产品： C2C12 细胞
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Aronia melanocarpa anthocyanin extracts are an effective regulator of suppressor of cytokine signaling 3-dependent insulin resistance in HepG2 and C2C12 cells (2010-00-20)
期刊：Journal of Functional Foods
影响因子 ：5.6
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Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating the Pten/Akt pathway (2009-00-20)
期刊：EXPERIMENTAL PHYSIOLOGY
DOI：10.1113/EP088894
影响因子 ：2.7
引用产品： C2C12 细胞
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脓毒症通过抑制AKT/GSK3β磷酸化导致骨骼肌细胞膜nAChRs聚集障碍 (2011-09-20)
期刊：南方医科大学学报
DOI：10.12122/j.issn.1673-4254.2019.11.11
影响因子 ：1.4
引用产品： C2C12 细胞
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Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction (2004-09-20)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.0
引用产品： C2C12 细胞
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MiR‐499 regulates myoblast proliferation and differentiation by targeting transforming growth factor β receptor 1 (2009-08-20)
期刊：Journal of Cellular Physiology
影响因子 ：5.6
引用产品： C2C12 细胞
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Low frequency pulsed electromagnetic field promotes C2C12 myoblasts proliferation via activation of MAPK/ERK pathway (2006-06-20)
期刊：Biochemical and Biophysical Research Communications
DOI：10.1016/j.bbrc.2016.09.044
影响因子 ：3.1
引用产品： C2C12 细胞
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