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产品概述
| 名称 | MIA PaCa-2 (人胰腺癌细胞) (STR鉴定正确) |
| 别称 | MIA-PaCa-2; MIA-PACA-2; MIA-Pa-Ca-2; MIA Paca2; MIA PaCa2; MiaPaCa-2; MIAPACA-2; MiaPaca.2; MiaPaCa2; Miapaca2; MIAPaCa2; MIAPACA2; Mia PACA 2; MIAPaCa-2; PaCa2 |
| 种属 | 人 |
| 生长特性 | 半贴半悬 |
| 细胞形态 | 上皮样贴壁细胞，伴有圆形漂浮细胞 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:8 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | The MIA PaCa-2 cell line was established by A. Yunis, et al. in 1975 from tumor tissue of the pancreas obtained from a 65-year-old Caucasian male. |
| 年龄（性别） | 男性；65岁 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | 26 hours (PubMed=25984343); 25.7 +- 4.3 hours (PubMed=27067801); 40 hours, 18 hours, in serum-free medium (PubMed=23386380); ~40 hours (ATCC); ~30-40 hours (DSMZ) |
| 基因表达情况 | human colony stimulating factor, subclass I (CSF-I); plasminogen activator |
| 保藏机构 | ATCC; CRL-1420DSMZ; ACC-733ECACC; 85062806JCRB; JCRB0070 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10 D2S1338 25 D3S1358 16 D5S818 12,13 D7S820 12 D8S1179 16 D13S317 12,13 D16S539 10,13 D18S51 12 D19S433 15 D21S11 29,31.2 FGA 22 PentaD 12,16 PentaE 13,18 TH01 9,10 TPOX 9 vWA 15 D6S1043 12 D12S391 19 D2S441 14 -
STR鉴定图
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参考文献
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Albumin binding revitalizes NQO1 bioactivatable drugs as novel therapeutics for pancreatic cancer(2022/08/04)
作者：Lei Dou, Huiqin Liu, Kaixin Wang
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2022.07.033
影响因子 ：10.800
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HMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells(2024/03/16)
作者：Ziyang Luo, Qingfang Zheng, Shazhou Ye
期刊：Cell Death & Disease
DOI：10.1038/s41419-024-06592-y
影响因子 ：9.000
引用产品：CL-0627
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Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5′-UTR RNA G-Quadruplexes(2024/01/25)
作者：Maolin Li, Letian Dai, Zhuoyu Gao
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c01773
影响因子 ：7.300
引用产品：CL-0627
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Synthesis and anti-tumor activity of nitrogen-containing derivatives of the natural product diphyllin(2022/08/26)
作者：Yang Li, Qing Lu, Ruoxuan Xiao
期刊：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1016/j.ejmech.2022.114708
影响因子 ：6.700
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Anti‑silencing function 1B promotes the progression of pancreatic cancer by activating c‑Myc(2022/11/17)
作者：Min Zhang, Luyang Zhang, Minghe Zhou
期刊：INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子 ：5.884
引用产品：CL-0627
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Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2(2022/09/20)
作者：Meijie Chen, Xuena Li, Bulin Du
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：5.800
引用产品：CL-0027 CL-0042 CL-0059 CL-0184 CL-0448 CL-0627 CM-0059 CM-0448A
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HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones(2023/11/23)
作者：Yingcan Xu, Kehui Zhu, Jiakang Wu
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2023.2276768
影响因子 ：5.800
引用产品：CL-0627
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5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis(2023/10/12)
作者：Wenpeng Cao, Zhirui Zeng, Shan Lei
期刊：Biomolecules
影响因子 ：5.500
引用产品：CL-0627
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COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation(2023/02/26)
作者：Yao Song, Lei Wang, Kaidong Wang
期刊：Cancers
影响因子 ：5.200
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KIF2C Facilitates Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma(2023/02/27)
作者：Xing Huang, Feng Zhao, Quan Wu
期刊：Cancers
影响因子 ：5.200
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MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells(2024/02/29)
作者：Wuming Liu, Yifan Ren, Tao Wang
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2024.176462
影响因子 ：5.000
引用产品：CL-0627
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Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer(2023/10/24)
作者：Xu Chen, Qihang Yuan, Hewen Guan
期刊：Frontiers in Oncology
影响因子 ：4.700
引用产品：CL-0627
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GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma(2022/06/05)
作者：Xiaoyuan Sun, Huijun Chu, Ke Lei
期刊：PANCREATOLOGY
影响因子 ：3.977
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Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis(2023/10/30)
作者：Zemin Zhu, Bo Yi, Zikai Tang
期刊：BMC CANCER
DOI：10.1186/s12885-023-11557-z
影响因子 ：3.800
引用产品：CL-0627
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Systematic analysis of expression profiles and prognostic significance of the FGF gene family in pancreatic adenocarcinoma(2022/10/19)
作者：Yuxin Chen, Xiaojuan Liu, Ling Yang
期刊：Oncology Letters
影响因子 ：2.900
引用产品：CL-0627
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Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer(2023/02/12)
作者：Jiaxing Du, Yongsheng Chen, Genglong Liu
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
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