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产品概述
| 名称 | MG-63 (人骨肉瘤细胞) (STR鉴定正确) |
| 别称 | M-G63; MG63 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | MG-63细胞源自14岁患有骨肉瘤的白人男性；聚次黄嘌呤核苷-聚胞嘧啶核苷酸、放线菌酮和放线菌素D可以诱导MG-63细胞产生高水平的干扰素。MG-63细胞表达TGF-β受体Ⅰ和Ⅱ。 |
| 年龄（性别） | 男性；14岁 |
| 组织来源 | 骨；骨肉瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肉瘤细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~28-38 hours |
| 受体表达情况 | transforming growth factor beta (TGF-beta) RI, expressed;transforming growth factor beta (TGF-beta) RII, expressed |
| 基因表达情况 | interferon |
| 保藏机构 | ATCC; CRL-1427 ECACC; 86051601 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,12 D2S1338 17,24 D3S1358 15 D5S818 11,12 D7S820 10 D8S1179 13 D13S317 11 D16S539 11,12 D18S51 12,16 D19S433 13,14 D21S11 30 FGA 21,25 PentaD 9,13 PentaE 11,12 TH01 9.3 TPOX 8,11 vWA 16,19 D6S1043 12,17 D12S391 15,20 D2S441 10,11 -
STR鉴定图
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参考文献
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Dipsacus Asperoides-Derived Exosomes-Like Nanoparticles Inhibit the Progression of Osteosarcoma via Activating P38/JNK Signaling Pathway (2024-02-01)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
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Revelation of Adhesive Proteins Affecting Cellular Contractility through A Reference-free Traction Force Microscopy (2024-02-28)
期刊：Journal of Materials Chemistry B
影响因子 ：7.0
引用产品： MG-63 细胞
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Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway (2024-01-08)
期刊：MOLECULAR MEDICINE
DOI：10.1186/s10020-024-00778-y
影响因子 ：5.7
引用产品： U-2 OS [U2OS] 细胞 , Saos-2 细胞 , MG-63 细胞
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Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression (2024-02-29)
期刊：CELLULAR AND MOLECULAR BIOLOGY
影响因子 ：1.6
引用产品： MNNG/HOS Cl #5 [R-1059-D] 细胞 , U-2 OS [U2OS] 细胞 , MG-63 细胞 , hFOB 1.19 细胞
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Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells (2023-09-30)
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-023-02129-1
影响因子 ：10.2
引用产品： 143B 细胞 , MG-63 细胞 , Saos-2 细胞 , U-2 OS [U2OS] 细胞 , 人骨髓间充质干细胞
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Janus-Inspired Core–Shell Structure Hydrogel Programmatically Releases Melatonin for Reconstruction of Postoperative Bone Tumor (2023-01-05)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： U-2 OS [U2OS] 细胞 , MG-63 细胞 , B16 细胞
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Anticancer and bone-enhanced nano-hydroxyapatite/gelatin/polylactic acid fibrous membrane with dual drug delivery and sequential release for osteosarcoma (2023-04-13)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2023.124406
影响因子 ：8.2
引用产品： MG-63 细胞 , MC3T3-E1 Subclone 24 细胞
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A1BG-AS1 promotes the biological functions of osteosarcoma cells via regulating the microRNA-148a-3p/USP22 axis and stabilizing the expression of SIRT1 through deubiquitinase function (2023-10-03)
期刊：EXPERT OPINION ON THERAPEUTIC TARGETS
DOI：10.1080/14728222.2023.2263908
影响因子 ：5.8
引用产品： U-2 OS [U2OS] 细胞 , Saos-2 细胞 , MG-63 细胞 , HOS 细胞 , SJSA-1 细胞 , hFOB 1.19 细胞 , McCoy's 5A 培养基 , MEM 培养基 , RPMI-1640 培养基 , DMEM/F12 培养基
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COPI Vesicle Disruption Inhibits Mineralization via mTORC1-Mediated Autophagy (2023-12-26)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
引用产品： MG-63 细胞
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Anoikis patterns exhibit distinct prognostic and immune landscapes in Osteosarcoma (2023-01-09)
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.109684
影响因子 ：5.6
引用产品： HOS 细胞 , MG-63 细胞 , hFOB 1.19 细胞
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m7G-related genes predict prognosis and affect the immune microenvironment and drug sensitivity in osteosarcoma (2023-08-16)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2023.1158775
影响因子 ：5.6
引用产品： U-2 OS [U2OS] 细胞 , MG-63 细胞
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8-Methoxyflindersine-Induced Apoptosis and Cell Cycle Disorder Involving MAPK Signaling Activation in Human Colorectal Cancer Cells (2023-04-28)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
引用产品： CA922 细胞 , Hep G2 细胞 , MCF7 [MCF-7] 细胞 , MG-63 细胞
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MicroRNA PC-3p-2869 Regulates Antler Growth and Inhibits Proliferation and Migration of Human Osteosarcoma and Chondrosarcoma Cells by Targeting CDK8, EEF1A1, and NTN1 (2023-06-29)
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.6
引用产品： 293T [HEK-293T] 细胞 , U-2 OS [U2OS] 细胞 , MG-63 细胞 , SW 1353 细胞
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ATRX loss suppresses the type I interferon response in sarcoma cells through chromatin remodeling (2023-08-15)
期刊：American Journal of Cancer Research
DOI：PMID:37693131
影响因子 ：5.3
引用产品： HOS 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞 , 293T [HEK-293T] 细胞 , MG-63 细胞
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Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling (2023-06-15)
期刊：American Journal of Cancer Research
DOI：PMID:37424831
影响因子 ：5.3
引用产品： hFOB 1.19 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞 , Saos-2 细胞 , MG-63 细胞
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Network pharmacology-based research on the effect of angelicin on osteosarcoma and the underlying mechanism (2023-06-10)
期刊：Aging-US
影响因子 ：5.2
引用产品： MG-63 细胞
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Three-dimensional-printed MPBI@β-TCP scaffold promotes bone regeneration and impedes osteosarcoma under near-infrared laser irradiation (2023-04-18)
期刊：FASEB JOURNAL
影响因子 ：4.8
引用产品： MG-63 细胞
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Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1–3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment (2023-06-08)
期刊：Frontiers in Oncology
影响因子 ：4.7
引用产品： MG-63 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞 , K7M2 wt [K7M2-WT] 细胞 , RAW 264.7 细胞
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Prognosis-related VDAC1 regulates the proliferation and apoptosis of osteosarcoma cells via the MAPK signaling pathway (2023-03-05)
期刊：GENOMICS
DOI：10.1016/j.ygeno.2023.110595
影响因子 ：4.4
引用产品： hFOB 1.19 细胞 , MNNG/HOS Cl #5 [R-1059-D] 细胞 , MG-63 细胞 , 143B 细胞 , U-2 OS [U2OS] 细胞
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RING finger gene 180 inhibits osteosarcoma progression through regulating chromobox homolog 4 ubiquitination (2023-04-24)
期刊：CELL CYCLE
DOI：10.1080/15384101.2023.2205201
影响因子 ：4.3
引用产品： 293T [HEK-293T] 细胞 , hFOB 1.19 细胞 , MNNG/HOS Cl #5 [R-1059-D] 细胞 , Saos-2 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞
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Osteoblast-derived exosomes promote osteogenic differentiation of osteosarcoma cells via URG4/Wnt signaling pathway (2023-10-11)
期刊：BONE
DOI：10.1016/j.bone.2023.116933
影响因子 ：4.1
引用产品： MG-63 细胞 , U-2 OS [U2OS] 细胞
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Polydopamine and CuS/CaCO3 nanocomposites coated titanium alloy screw as efficient antibacterial device (2023-05-18)
期刊：VACUUM
DOI：10.1016/j.vacuum.2023.112208
影响因子 ：4.0
引用产品： MG-63 细胞
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Caspase-3/GSDME-mediated pyroptosis leads to osteogenic dysfunction of osteoblast-like cells (2023-04-01)
期刊：ORAL DISEASES
影响因子 ：3.8
引用产品： MG-63 细胞
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Comprehensive landscape of TGFβ-related signature in osteosarcoma for predicting prognosis, immune characteristics, and therapeutic response (2023-05-12)
期刊：Journal of Bone Oncology
影响因子 ：3.4
引用产品： HOS 细胞 , MG-63 细胞 , hFOB 1.19 细胞
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CeO2 Nanoparticle Bioactive Materials Promote MG-63 Osteogenic Differentiation and Antioxidant Activity Through NRF2 Signaling (2023-11-10)
期刊：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
DOI：10.1007/s12010-023-04766-6
影响因子 ：3.0
引用产品： MG-63 细胞 , RPMI-1640 培养基
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High Expression of PKMYT1 Predicts Poor Prognosis and Aggravates the Progression of Osteosarcoma via the NF-ΚB Pathway in MG63 Cells (2023-07-01)
期刊：CURRENT CANCER DRUG TARGETS
DOI：10.2174/1568009623666230206154944
影响因子 ：3.0
引用产品： MG-63 细胞
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LPS combined with CD47mAb enhances the anti‑osteosarcoma ability of macrophages (2023-03-28)
期刊：Oncology Letters
影响因子 ：2.9
引用产品： RAW 264.7 细胞 , K7M2 wt [K7M2-WT] 细胞 , U-2 OS [U2OS] 细胞 , MG-63 细胞
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Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression (2023-02-21)
期刊：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
影响因子 ：2.9
引用产品： HOS 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞 , 青霉素-链霉素溶液 (双抗)，100× , hFOB 1.19 细胞
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Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy (2023-11-22)
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04338-8
影响因子 ：2.6
引用产品： MG-63 细胞 , HOS 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞
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DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway (2023-02-27)
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-03572-4
影响因子 ：2.6
引用产品： hFOB 1.19 细胞 , U-2 OS [U2OS] 细胞 , Saos-2 细胞 , MG-63 细胞
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ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells (2023-11-29)
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-023-04406-z
影响因子 ：2.6
引用产品： MG-63 细胞 , HOS 细胞 , hFOB 1.19 细胞 , MEM 培养基 , DMEM高糖 培养基 , G-418溶液 (50mg/mL)
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Thorium inhibits human respiratory chain complex IV (cytochrome c oxidase) (2002-02-20)
期刊：Journal of Hazardous Materials
DOI：10.1016/j.jhazmat.2021.127546
影响因子 ：14.2
引用产品： MG-63 细胞 , Hep G2 细胞 , MEM (含NEAA) 培养基 , DMEM/F12 培养基 , 特级胎牛血清
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Chitosan based photothermal scaffold fighting against bone tumor-related complications: Recurrence, infection, and defects (2022-10-26)
期刊：CARBOHYDRATE POLYMERS
DOI：10.1016/j.carbpol.2022.120264
影响因子 ：10.7
引用产品： 小鼠骨髓间充质干细胞 , MG-63 细胞 , MNNG/HOS Cl #5 [R-1059-D] 细胞
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3D-printed magnesium-doped wollastonite/nano-hydroxyapatite bioceramic scaffolds with high strength and anti-tumor property (2022-12-06)
期刊：MATERIALS & DESIGN
DOI：10.1016/j.matdes.2022.111464
影响因子 ：9.4
引用产品： MG-63 细胞 , 特级胎牛血清 , 青霉素-链霉素溶液 (双抗)，100× , 大鼠骨髓间充质干细胞
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Verification of Ferroptosis Subcluster-Associated Genes Related to Osteosarcoma and Exploration of Immune Targeted Therapy (2022-09-28)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.3
引用产品： MG-63 细胞 , hFOB 1.19 细胞
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Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect (2022-11-17)
期刊：International Journal of Nanomedicine
影响因子 ：7.0
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RNA-Sequence Reveals the Regulatory Mechanism of miR-149 on Osteoblast Skeleton under Mechanical Tension (2022-09-23)
期刊：Stem Cells International
影响因子 ：5.1
引用产品： MG-63 细胞 , DMEM高糖 培养基
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Zinc finger Asp-His-His-Cys palmitoyl -acyltransferase 19 accelerates tumor progression through wnt/β-catenin pathway and is upregulated by miR-940 in osteosarcoma (2003-02-20)
期刊：Bioengineered
DOI：10.1080/21655979.2022.2040827
影响因子 ：4.9
引用产品： U-2 OS [U2OS] 细胞 , MG-63 细胞
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The effect of resolvin D1 on bone regeneration in a rat calvarial defect model (2022-08-18)
期刊：Journal of Tissue Engineering and Regenerative Medicine
影响因子 ：4.3
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PROSER2 is a poor prognostic biomarker for patients with osteosarcoma and promotes proliferation, migration and invasion of osteosarcoma cells (2022-11-08)
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.8
引用产品： hFOB 1.19 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞
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Macroscopic Supramolecular Assembly Strategy to Construct 3D Biocompatible Microenvironments with Site-Selective Cell Adhesion (2006-01-20)
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.5
引用产品： MG-63 细胞 , PC-12 (Undifferentiated) 细胞 , 重组人胰岛素溶液 (10mg/mL) , MEM非必需氨基酸溶液 (NEAA)，100× , PUMC-HUVEC-T1 , CCC-SMC-1 细胞
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lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression (2008-01-20)
期刊：Molecular Therapy-Nucleic Acids
DOI：10.1016/j.omtn.2021.08.022
影响因子 ：8.8
引用产品： Saos-2 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞 , HOS 细胞
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Ten-gene signature reveals the significance of clinical prognosis and immuno-correlation of osteosarcoma and study on novel skeleton inhibitors regarding MMP9 (2007-01-20)
期刊：Cancer Cell International
DOI：10.1186/s12935-021-02041-4
影响因子 ：5.8
引用产品： HOS 细胞 , MG-63 细胞 , DMEM高糖完全培养基 (含10%FBS)
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Down-regulation of PRR11 affects the proliferation, migration and invasion of osteosarcoma by inhibiting the Wnt/β-catenin pathway (2009-01-20)
期刊：Journal of Cancer
影响因子 ：3.9
引用产品： Saos-2 细胞 , MG-63 细胞 , U-2 OS [U2OS] 细胞 , hFOB 1.19 细胞
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Enterococcus faecalis OG1RF induces apoptosis in MG63 cells via caspase-3/-8/-9 without activation of caspase-1/GSDMD (2008-01-20)
期刊：Oral Diseases
影响因子 ：3.8
引用产品： MG-63 细胞 , MEM (含NEAA) 培养基
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Nanoscale Au@SiO2‑drug/VEGF as an in vivo probe for osteosarcoma diagnosis and therapy (2009-01-20)
期刊：Oncology Letters
影响因子 ：2.9
引用产品： MG-63 细胞
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Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner (2012-01-20)
期刊：Journal of Orthopaedic Surgery and Research
DOI：10.1186/s13018-021-02868-7
影响因子 ：2.6
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Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells (2010-01-20)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：0.0
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Long Non-Coding RNA OIP5-AS1 Knockdown Enhances CDDP Sensitivity in Osteosarcoma via miR-377-3p/FOSL2 Axis (2005-00-20)
期刊：OncoTargets and Therapy
影响因子 ：4.0
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Sirt1 modulates H3 phosphorylation and facilitates osteosarcoma cell autophagy (2008-09-20)
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1648280
影响因子 ：5.8
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3D printed porous PLA/nHA composite scaffolds with enhanced osteogenesis and osteoconductivity in vivo for bone regeneration (2009-09-20)
期刊：Biomedical Materials
影响因子 ：4.0
引用产品： MG-63 细胞
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Lithium-incorporated deproteinized bovine bone substitute improves osteogenesis in critical-sized bone defect repair: (2004-08-20)
期刊：Journal Of Biomaterials Applications
影响因子 ：2.9
引用产品： MG-63 细胞
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