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产品概述
| 名称 | ZR-75-1 (人乳腺癌细胞) (STR鉴定正确) |
| 别称 | ZR751; ZR75-1; ZR75_1 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:3 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | ZR-75-1细胞产生高水平的黏液素MUC-1 mRNA，低水平的MUC-2 mRNA，但不表达MUC-3基因；ZR-75-1细胞表达雌激素受体。 |
| 年龄（性别） | 女性 |
| 组织来源 | 乳腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~50-80 hours |
| 致瘤性 | Yes, forms tumors in nude mice. |
| 受体表达情况 | estrogen receptor, expressed |
| 基因表达情况 | mucin (apomucin, MUC-1, MUC-2) |
| 保藏机构 | ATCC; CRL-1500 ECACC; 87012601 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,11 D2S1338 16,25 D3S1358 15,16 D5S818 13 D7S820 10,11 D8S1179 11,13 D13S317 9 D16S539 11 D18S51 13,14 D19S433 13,14 D21S11 31 FGA 20,22 PentaD 14 PentaE 7,14 TH01 7,9.3 TPOX 8 vWA 16,18 D6S1043 12 D12S391 21 D2S441 11,15 -
STR鉴定图
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参考文献
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TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9 (2024-03-19)
作者：Ran Hu:1.Department of Pathology, College of Basic Medical Sciences, First Affiliated Hospital of China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, 110122, China. ; 2.Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China. ; Yu Cao:1.Department of Surgical Oncology and Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, China. ; Yuanyuan Wang:1.Department of Anesthesiology, The Fourth Affiliated Hospital, China Medical University, Shenyang, China. ; Tingting Zhao:1.Department of Surgical Oncology and Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, China. ; Kaibo Yang:1.Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, China. ; 2.Department of Immunology, College of Basic Medical Sciences of China Medical University, Shenyang, China. ; Mingwei Fan:1.Department of Pathology, College of Basic Medical Scienc
期刊：TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9
DOI：10.1186/s13058-024-01802-z
影响因子 ：7.4
引用产品： ZR-75-1 细胞 , MDA-MB-468 细胞
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TP53R175H mutation promotes breast cancer cell proliferation through CORO1A–P38 MAPK pathway regulation (2024-02-07)
作者：Yali Su:1.Department of Clinical Laboratory, North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Care Hospital-Tangshan, China; Key Laboratory of Molecular Medicine for Abnormal Development and Related Diseases in Tangshan City-Tangshan, China. ; Jiaxuan Zhao:1.Department of Clinical Laboratory, North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Care Hospital-Tangshan, China; Key Laboratory of Molecular Medicine for Abnormal Development and Related Diseases in Tangshan City-Tangshan, China. ; Haoran Fu:1.Department of Clinical Laboratory, North China University of Science and Technology Affiliated Tangshan Maternal and Child Health Care Hospital-Tangshan, China; Key Laboratory of Molecular Medicine for Abnormal Development and Related Diseases in Tangshan City-Tangshan, China. ; Zeliang Liu:1.Department of Clinical Laboratory, North China University of Science and Technology Affiliated Tangshan Ma
期刊：TP53R175H mutation promotes breast cancer cell proliferation through CORO1A–P38 MAPK pathway regulation
影响因子 ：5.8
引用产品： ZR-75-1 细胞 , MCF 10A 细胞 , MCF 10A细胞专用培养基
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An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2 (2024-01-30)
作者：Yue Meng:1.Department of Clinical Laboratory, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 ZhongShan Road, Guangzhou, 51000, Guangdong, China. mengyue1990@bjmu.edu.cn. ; Dianrong Zhou:1.Department of Clinical Laboratory, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 ZhongShan Road, Guangzhou, 51000, Guangdong, China. ; 2.Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 51000, Guangdong, China. ; Ying Luo:1.Department of Clinical Laboratory, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 ZhongShan Road, Guangzhou, 51000, Guangdong, China. ; Jierong Chen:1.Department of Clinical Laboratory, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 ZhongShan Road, Guangzhou, 51000, Guangdong, China. ; Hui Li:1.Departm
期刊：An estrogen-regulated long non-coding RNA NCALD promotes luminal breast cancer proliferation by activating GRHL2
DOI：10.1186/s12935-024-03245-0
影响因子 ：5.8
引用产品： MDA-MB-231/GFP 细胞 , MDA-MB-468 细胞 , SK-BR-3 [SKBR3] 细胞 , MCF 10A 细胞 , ZR-75-1 细胞
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A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer (2023-07-05)
作者：Runjie Song:1.State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. ; Peilan Guo:1.State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. ; Xin Ren:1.State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. ; Lijun Zhou:1.State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. ; Peng Li:1.State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. ; Nafis A Rahman:1.Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland. ; 2.Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland. ; Sławomir Wołczyński:1.Department of Reproduction a
期刊：A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer
DOI：10.1186/s12943-023-01806-x
影响因子 ：37.3
引用产品： MDA-MB-231 细胞 , MDA-MB-468 细胞 , 293T [HEK-293T] 细胞 , Hs 578T 细胞 , MCF7 [MCF-7] 细胞 , T-47D 细胞 , ZR-75-1 细胞 , MCF 10A 细胞
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Scoparone inhibits breast cancer cell viability through the NF‑κB signaling pathway (2023-05-17)
作者：Xiaoying Wu:1.Mongolian Medical College, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia Autonomous Region 028000, P.R. China. ; Xiaobo Li:1.Department of Hematology, Mongolian Medical Hospital, Fuxin Mongolian Autonomous County 123199, P.R. China. ; Jing Li:1.Department of Hematology, Mongolian Medical Hospital, Fuxin Mongolian Autonomous County 123199, P.R. China. ; Xinrui Zhao:1.Liaoning Boaotaihe Health Technology Co., Ltd., Fuxin, Liaoning 123000, P.R. China. ; Yongyuan Cui:1.Liaoning Boaotaihe Health Technology Co., Ltd., Fuxin, Liaoning 123000, P.R. China. ; Chaolu Eerdun:1.Medical Department, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia Autonomous Region 028000, P.R. China. ;
期刊：Scoparone inhibits breast cancer cell viability through the NF‑κB signaling pathway
影响因子 ：2.7
引用产品： MCF 10A 细胞 , MCF7 [MCF-7] 细胞 , MDA-MB-231 细胞 , ZR-75-1 细胞 , HCC1937 细胞 , 293 [HEK-293] 细胞
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Asiaticoside hampers epithelial–mesenchymal transition by promoting PPARG expression and suppressing P2RX7-mediated TGF-β/Smad signaling in triple-negative breast cancer (2022-11-28)
作者：Xuemei Huang:1.Department of Oncology and Hematology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China. ; Zhiqin Jia:1.Department of Obstetrics and Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China. ; Xiangyue Li:1.Department of Obstetrics and Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China. ; Zhilan Hu:1.Department of Obstetrics and Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China. ; Xiaolan Yu:1.Department of Obstetrics and Gynecology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China. ; Jiyi Xia:1.Department of Oncology and Hematology, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China. ; 2.Dazhou Vocational College of Chinese Medicine, Dazhou,
期刊：Asiaticoside hampers epithelial–mesenchymal transition by promoting PPARG expression and suppressing P2RX7-mediated TGF-β/Smad signaling in triple-negative breast cancer
DOI：10.1002/ptr.7692
影响因子 ：6.4
引用产品： 人乳腺上皮细胞 , MDA-MB-453 细胞 , MDA-MB-231细胞专用培养基 (DMEM) , MCF7 [MCF-7] 细胞 , ZR-75-1 细胞
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Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader (2006-09-20)
作者：Yue Zhao:1.Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR China. ; Chenxi Zhao:1.Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei Province, 430072, PR China. ; Jin Lu:1.Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR China. ; Jun Wu:1.Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei Province, 430072, PR China. ; Changhao Li:1.Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei Province, 430072, PR China. ; Zhiye Hu:1.Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, PR China. ; Wei Tian:1.Key Laboratory of Combinato
期刊：Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader
DOI：10.1016/j.phrs.2019.104294
影响因子 ：9.3
引用产品： ZR-75-1 细胞
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