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| 名称 | HT-29 (人结肠癌细胞) (STR鉴定正确) |
| 别称 | HT 29; HT29 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
生长培养基:
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:6 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | HT-29细胞是由J·Fogh在1964年用移植培养方法和含15%FBS的F12培养液从原发性肿瘤分离的；近来，已建株的培养细胞用含相同血清McCoy's5A培液培养。HT-29细胞在裸鼠中致瘤，也能在类固醇处理的地鼠中致瘤。HT-29细胞合成IgA、CEA、蛋白绑定TGF-β的分泌成分和粘液素等。 |
| 年龄（性别） | 女性；44岁 |
| 组织来源 | 结直肠腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肠癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~36-60 hours |
| 致瘤性 | Yes, in nude mice; forms well differentiated adenocarcinoma consistent with colonic primary (grade I); tumors also form in steroid treated hamsters. |
| 受体表达情况 | human adrenergic alpha2A, urokinase receptor (u-PAR), vitamin D (moderate expression), urokinase receptor (u-PAR); vitamin D (moderate expression), human adrenergic alpha2A |
| 基因表达情况 | secretory component of IgA; carcinoembryonic antigen (CEA); transforming growth factor beta binding protein; mucin, myc+; ras+; myb+; fos+; sis+; p53+; abl -; ros -; src -, Blood Type A; Rh+; HLA A1, A3, B12, B17, Cw5, HT-29 cells are negative for CD4, but there is cell surface expression of galactose ceramide (a possible alternative receptor for HIV). |
| 保藏机构 | ATCC; HTB-38 BCRJ; 0111 CCLV; CCLV-RIE 0960 DSMZ; ACC-299 ECACC; 91072201 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 19,23 D3S1358 15,17 D5S818 11,12 D7S820 10 D8S1179 10,16 D13S317 11,12 D16S539 11,12 D18S51 13 D19S433 14 D21S11 29,30 FGA 20,22 PentaD 11,13 PentaE 14,16 TH01 6,9 TPOX 8,9 vWA 17,19 D6S1043 12,14 D12S391 18.3,21 D2S441 11 -
STR鉴定图
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参考文献
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Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis (2024-01-17)
期刊：Acta Pharmaceutica Sinica B
DOI：10.1016/j.apsb.2024.01.006
影响因子 ：14.5
引用产品： 特级胎牛血清 , LoVo 细胞 , HT-29 细胞 , HCT 116 细胞 , SW620 细胞 , RKO 细胞 , DLD-1 细胞 , HCT-8 [HRT-18] 细胞
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Quercetin-induced pyroptosis in colon cancer through NEK7-mediated NLRP3 inflammasome-GSDMD signaling pathway activation (2024-03-15)
期刊：American Journal of Cancer Research
影响因子 ：5.3
引用产品： HCT 116 细胞 , HT-29 细胞
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Colorectal cancer with low SLC35A3 is associated with immune infiltrates and poor prognosis (2024-01-03)
期刊：Scientific Reports
DOI：10.1038/s41598-023-51028-w
影响因子 ：4.6
引用产品： NCM460细胞 , HCT 116 细胞 , HT-29 细胞 , SW620 细胞
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10-Secocycloartane (=9,19-cyclo-9,10-secolanostane) triterpenoid saponins: Huangqiyenins M–X from Astragalus membranaceus (Fisch.) Bge (2024-03-30)
期刊：PHYTOCHEMISTRY
DOI：10.1016/j.phytochem.2024.114072
影响因子 ：3.8
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Bacteria-Induced Colloidal Encapsulation for Probiotic Oral Delivery (2023-03-22)
期刊：ACS Nano
影响因子 ：17.1
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A possible but unrecognized risk of acceptable daily intake dose triazole pesticides exposure—bile acid disturbance induced pharmacokinetic changes of oral medication (2023-02-21)
期刊：CHEMOSPHERE
DOI：10.1016/j.chemosphere.2023.138209
影响因子 ：8.8
引用产品： HT-29 细胞 , McCoy's 5A 培养基
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Targeted EpCAM-binding for the development of potent and effective anticancer proteins (2023-02-28)
期刊：BIOMEDICINE & PHARMACOTHERAPY
DOI：10.1016/j.biopha.2023.114443
影响因子 ：7.5
引用产品： HT-29 细胞 , MCF7 [MCF-7] 细胞 , Hela 细胞 , Caco-2 细胞
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Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status (2023-05-26)
期刊：Stem Cell Research & Therapy
DOI：10.1186/s13287-023-03334-3
影响因子 ：7.5
引用产品： LS 174T [LS174T] 细胞 , HT-29 细胞 , PUMC-HUVEC-T1 细胞
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Investigation of the Effects of Glabridin on the Proliferation, Apoptosis, and Migration of the Human Colon Cancer Cell Lines SW480 and SW620 and Its Mechanism Based on Reverse Virtual Screening and Proteomics (2023-01-05)
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.3
引用产品： HT-29 细胞 , HCT 116 细胞
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USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer (2023-08-03)
期刊：CELL BIOLOGY AND TOXICOLOGY
DOI：10.1007/s10565-023-09822-9
影响因子 ：6.1
引用产品： HT-29 细胞 , HCT 116 细胞 , LoVo 细胞 , CW-2 细胞
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Identification and validation of a novel prognosis model based on m5C-related long non-coding RNAs in colorectal cancer (2023-09-05)
期刊：Cancer Cell International
DOI：10.1186/s12935-023-03025-2
影响因子 ：5.8
引用产品： NCM460 细胞 , SW620 细胞 , HCT 116 细胞 , SW480 [SW-480] 细胞 , DLD-1 细胞 , LoVo 细胞 , HT-29 细胞
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A Genetic Algorithm-Based Ensemble Learning Framework for Drug Combination Prediction (2023-06-12)
期刊：Journal of Chemical Information and Modeling
影响因子 ：5.6
引用产品： HT-29 细胞
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A Moexitecan Magnetic Liposomal Strategy for Ferroptosis-Enhanced Chemotherapy (2023-07-24)
期刊：Pharmaceutics
DOI：10.3390/pharmaceutics15072012
影响因子 ：5.4
引用产品： HT-29 细胞 , Hep G2 细胞 , PC-3 细胞 , McCoy's 5A 培养基 , MEM (含NEAA) 培养基 , Ham's F-12K 培养基
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Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells (2023-03-12)
期刊：FEBS Journal
影响因子 ：5.4
引用产品： HT-29 细胞 , HCT 116 细胞 , SW480 [SW-480] 细胞 , SW620 细胞 , NCM460 细胞
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The traditional herb Sargentodoxa cuneata alleviates DSS-induced colitis by attenuating epithelial barrier damage via blocking necroptotic signaling (2023-11-03)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
引用产品： HT-29 细胞 , HT-29细胞专用培养基
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Qingchang Wenzhong Decoction ameliorates intestinal inflammation and intestinal barrier dysfunction in ulcerative colitis via the GC-C signaling pathway (2023-12-01)
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.4
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Identification of differentially expressed HERV-K(HML-2) loci in colorectal cancer (2023-06-05)
期刊：Frontiers in Microbiology
DOI：10.3389/fmicb.2023.1192900
影响因子 ：5.2
引用产品： HT-29 细胞 , SW480 [SW-480] 细胞
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KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling (2023-09-13)
期刊：Aging-US
影响因子 ：5.2
引用产品： SW480 [SW-480] 细胞 , HT-29 细胞
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Exosomal circCOL1A2 from cancer cells accelerates colorectal cancer progression via regulating miR-665/LASP1 signal axis (2023-04-12)
期刊：EUROPEAN JOURNAL OF PHARMACOLOGY
DOI：10.1016/j.ejphar.2023.175722
影响因子 ：5.0
引用产品： HT-29 细胞 , HCT 116 细胞 , LoVo 细胞 , SW480 [SW-480] 细胞 , SW620 细胞 , 人结肠黏膜上皮细胞
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The Upregulation of GSTO2 is Associated with Colon Cancer Progression and a Poor Prognosis (2023-01-11)
期刊：Journal of Oncology
影响因子 ：4.5
引用产品： HT-29 细胞 , HCT 116 细胞 , SW480 [SW-480] 细胞 , SW620 细胞
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IL-22 promotes occludin expression by activating autophagy and treats ulcerative colitis (2023-07-13)
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-023-04806-z
影响因子 ：4.3
引用产品： HT-29 细胞
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Annexin A9 promotes cell proliferation by regulating the Wnt signaling pathway in colorectal cancer (2023-06-22)
期刊：Human Cell
DOI：10.1007/s13577-023-00939-x
影响因子 ：4.3
引用产品： LoVo 细胞 , SW480 [SW-480] 细胞 , HCT 116 细胞 , HT-29 细胞 , 人结肠黏膜上皮细胞
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A deep learning approach for the detection and counting of colon cancer cells (HT-29 cells) bunches and impurities (2023-12-05)
期刊：PeerJ Computer Science
影响因子 ：3.8
引用产品： HT-29 细胞
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P300 increases CSNK2A1 expression which accelerates colorectal cancer progression through activation of the PI3K-AKT-mTOR axis (2023-06-28)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113694
影响因子 ：3.7
引用产品： HCT 116 细胞 , SW480 [SW-480] 细胞 , SW620 细胞 , LoVo 细胞 , HT-29 细胞
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PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer (2023-11-13)
期刊：DIGESTIVE DISEASES AND SCIENCES
DOI：10.1007/s10620-023-08168-w
影响因子 ：3.1
引用产品： HT-29 细胞 , HCT 116 细胞
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ELAPOR1 suppresses tumor progression in colorectal cancer and indicates favorable prognosis (2023-06-03)
期刊：Cancer Biomarkers
影响因子 ：3.1
引用产品： SW620 细胞 , RKO 细胞 , SW480 [SW-480] 细胞 , HT-29 细胞 , Caco-2 细胞 , HCT 116 细胞 , 293T [HEK-293T] 细胞
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Naringin Inhibits Colorectal Carcinogenesis by Inhibiting Viability of Colorectal Cancer Cells (2023-06-21)
期刊：Chinese Journal of Integrative Medicine
影响因子 ：2.9
引用产品： Caco-2 细胞 , HCT 116 细胞 , HT-29 细胞 , SW480 [SW-480] 细胞 , MEM 培养基 , McCoy's 5A 培养基 , Leibovitz's L-15 培养基
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Snail inhibits metastasis via regulation of E‑cadherin and is associated with prognosis in colorectal cancer (2023-05-05)
期刊：Oncology Letters
影响因子 ：2.9
引用产品： HCT 116 细胞 , HT-29 细胞
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RNF114 facilitates the proliferation, stemness, and metastasis of colorectal cancer (2023-07-27)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
引用产品： DLD-1 细胞 , HT-29 细胞 , SW480 [SW-480] 细胞
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Circ_0087862 promotes tumorigenesis and glycolysis in colorectal cancer by sponging miR-296-3p to regulate PGK1 expression (2023-07-17)
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.8
引用产品： LoVo 细胞 , SW620 细胞 , HT-29 细胞 , SW480 [SW-480] 细胞
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Development and validation of cuproptosis-related lncRNA signatures for prognosis prediction in colorectal cancer (2023-03-22)
期刊：BMC Medical Genomics
DOI：10.1186/s12920-023-01487-x
影响因子 ：2.7
引用产品： FHC 细胞 , SW480 [SW-480] 细胞 , SW620 细胞 , HCT-8 [HRT-18] 细胞 , HT-29 细胞 , LoVo 细胞
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Culturable Diversity and Biological Properties of Bacterial Endophytes Associated with the Medicinal Plants of Vernonia anthelmintica (L.) Willd (2023-08-30)
期刊：Applied Sciences-Basel
影响因子 ：2.7
引用产品： HT-29 细胞
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NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer (2023-02-27)
期刊：Journal of Gastrointestinal Oncology
影响因子 ：2.1
引用产品： HCT 116 细胞 , SW480 [SW-480] 细胞 , HT-29 细胞
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Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer (2022-08-28)
期刊：Advanced Science
影响因子 ：17.5
引用产品： SW480 [SW-480] 细胞 , HT-29 细胞 , SW620 细胞
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Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments (2022-11-09)
期刊：Science Advances
影响因子 ：15.0
引用产品： Hela 细胞 , HT-29 细胞 , HCT 116 细胞 , CT26.WT 细胞 , DMEM高糖 培养基 , McCoy's 5A 培养基 , RPMI-1640 培养基
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Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA (2022-12-15)
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02551-7
影响因子 ：12.7
引用产品： 293T [HEK-293T] 细胞 , NCM460 细胞 , SW480 [SW-480] 细胞 , DLD-1 细胞 , HT-29 细胞 , RKO 细胞 , HCT 116 细胞
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Anti-colon cancer effects of Spirulina polysaccharide and its mechanism based on 3D models (2022-12-26)
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2022.12.244
影响因子 ：8.0
引用产品： LoVo 细胞 , HT-29 细胞 , HCT 116 细胞
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SEDDS facilitate cinnamaldehyde crossing the mucus barrier: The perspective of mucus and Caco-2/HT29 co-culture models (2001-02-20)
期刊：International Journal Of Pharmaceutics
DOI：10.1016/j.ijpharm.2022.121461
影响因子 ：5.8
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Efficient, green extraction of two biflavonoids from Selaginella uncinata with deep eutectic solvents (2022-10-28)
期刊：MICROCHEMICAL JOURNAL
DOI：10.1016/j.microc.2022.108085
影响因子 ：5.3
引用产品： A549 [A-549] 细胞 , HCT 116 细胞 , HT-29 细胞 , SW 1990 细胞 , Hep G2 细胞 , Hela 细胞
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Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF/c-Kit signaling pathway (2022-10-18)
期刊：CELL CYCLE
DOI：10.1080/15384101.2022.2112486
影响因子 ：5.2
引用产品： HT-29 细胞 , SW480 [SW-480] 细胞
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Identification of KIF21B as a Biomarker for Colorectal Cancer and Associated with Poor Prognosis (2022-11-21)
期刊：Journal of Oncology
影响因子 ：4.5
引用产品： NCM460 细胞 , HT-29 细胞 , HCT 116 细胞 , SW48 细胞 , HCT-15 细胞
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Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK/mTOR/p70S6K-mediated autophagy (2001-02-20)
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-021-00854-5
影响因子 ：3.4
引用产品： HT-29 细胞
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CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/β-catenin pathway (2022-08-15)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2022.08.036
影响因子 ：3.3
引用产品： LS180 细胞 , SW480 [SW-480] 细胞 , HT-29 细胞 , HCT 116 细胞 , DLD-1 细胞
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Tanshinone IIA May Inhibit Gastric Cancer via Affecting the Intestinal Microbiome (2022-09-26)
期刊：Computational and Mathematical Methods in Medicine
影响因子 ：2.8
引用产品： HT-29 细胞
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ISLR affects colon cancer progression by regulating the epithelial–mesenchymal transition signaling pathway (2001-02-20)
期刊：Anti-Cancer Drugs
DOI：10.1097/CAD.0000000000001233
影响因子 ：2.3
引用产品： 人结肠黏膜上皮细胞 , CX-1 细胞 , SW480 [SW-480] 细胞 , HCT 116 细胞 , HT-29 细胞 , Hs 578T 细胞
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The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation (2010-01-20)
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-04289-0
影响因子 ：9.0
引用产品： HT-29 细胞
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Insight Into Polysaccharides From Panax ginseng C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy (2007-01-20)
期刊：Frontiers in Immunology
影响因子 ：7.3
引用产品： HT-29 细胞
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MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2 (2010-01-20)
期刊：Bioengineered
DOI：10.1080/21655979.2021.1996505
影响因子 ：4.9
引用产品： HT-29 细胞 , LoVo 细胞 , SW480 [SW-480] 细胞 , HCT 116 细胞 , PUMC-HUVEC-T1
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Label-free classification of dead and live colonic adenocarcinoma cells based on 2D light scattering and deep learning analysis (2006-01-20)
期刊：Cytometry Part A
影响因子 ：3.7
引用产品： HT-29 细胞
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Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model (2002-01-20)
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-021-00796-y
影响因子 ：3.4
引用产品： HT-29 细胞
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Osthole induces apoptosis of the HT-29 cells via endoplasmic reticulum stress and autophagy (2008-01-20)
期刊：Oncology Letters
影响因子 ：2.9
引用产品： HT-29 细胞
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MicroRNA‑9‑5p increases the sensitivity of colorectal cancer cells to 5‑fluorouracil by downregulating high mobility group A2 expression (2001-01-20)
期刊：Oncology Letters
影响因子 ：2.9
引用产品： HCT 116 细胞 , HT-29 细胞 , MET-5A细胞专用培养基
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Cullin-4B promotes cell proliferation and invasion through inactivation of p53 signaling pathway in colorectal cancer (2006-01-20)
期刊：Pathology Research And Practice
影响因子 ：2.8
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The combination of lactoferrin and linolenic acid inhibits colorectal tumor growth through activating AMPK/JNK-related apoptosis pathway (2005-01-20)
期刊：PeerJ
影响因子 ：2.7
引用产品： Hep G2 细胞 , AGS 细胞 , HCT 116 细胞 , DLD-1 细胞 , HT-29 细胞
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circASS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells by regulating the miR‑1269a/VASH1 axis (2008-01-20)
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.7
引用产品： HCT 116 细胞 , Caco-2 细胞 , LoVo 细胞 , SW480 [SW-480] 细胞 , HT-29 细胞
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SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip (2012-00-20)
期刊：Science Bulletin
DOI：10.1016/j.scib.2020.11.015
影响因子 ：18.9
引用产品： HT-29 细胞
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Indole-3-propionic Acid Improved the Intestinal Barrier by Enhancing Epithelial Barrier and Mucus Barrier (2012-00-20)
期刊：Journal Of Agricultural And Food Chemistry
影响因子 ：6.1
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miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition (2003-00-20)
期刊：Drug Design Development and Therapy
影响因子 ：4.8
引用产品： HCT 116 细胞 , SW620 细胞 , HT-29 细胞 , McCoy's 5A 培养基
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Blocking NFATc3 ameliorates azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer in mice via the inhibition of inflammatory responses and epithelial-mesenchymal transition (2007-00-20)
期刊：Cellular Signalling
DOI：10.1016/j.cellsig.2020.109707
影响因子 ：4.8
引用产品： HCT 116 细胞 , LoVo 细胞 , HT-29 细胞 , Ham's F-12K 培养基
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The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway (2009-00-20)
期刊：Investigational New Drugs
DOI：10.1007/s10637-020-01014-0
影响因子 ：3.4
引用产品： HCT 116 细胞 , SW480 [SW-480] 细胞 , SW620 细胞 , HT-29 细胞 , LoVo 细胞 , RKO 细胞
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Anti-cancer effects of Porphyra haitanensis polysaccharides on human colon cancer cells via cell cycle arrest and apoptosis without causing adverse effects in vitro (2008-00-20)
期刊：3 BIOTECH
DOI：10.1007/s13205-020-02379-y
影响因子 ：2.8
引用产品： HT-29 细胞 , LoVo 细胞 , SW480 [SW-480] 细胞
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Pseudophosphatase STYX promotes tumor growth and metastasis by inhibiting FBXW7 function in colorectal cancer (2006-09-20)
期刊：Cancer Letters
DOI：10.1016/j.canlet.2019.04.014
影响因子 ：9.7
引用产品： SW480 [SW-480] 细胞 , SW620 细胞 , HCT 116 细胞 , HT-29 细胞 , RKO 细胞 , LoVo 细胞
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miRNA-101通过靶向CDK8调控结肠癌细胞侵袭和Wnt/β-catenin通路活化 (2005-08-20)
期刊：肿瘤防治研究
DOI：10.3971/j.issn.1000-8578.2018.17.1558
影响因子 ：0.7
引用产品： HCT 116 细胞 , HT-29 细胞 , LoVo 细胞 , SW620 细胞 , COLO 205 细胞
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