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产品概述
| 名称 | CT26.WT (小鼠结肠癌细胞) (STR鉴定正确) |
| 别称 | CT26WT |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | CT26细胞是以N-亚硝基-N-甲基氨基甲酸酯(NNMU)诱导形成的未分化结肠癌细胞株，它克隆形成的细胞株命名为CT26.WT。用包含编码典型肿瘤相关抗原(TAA)β-半乳糖苷酶(β-gal)的lacZ基因的逆转录病毒载体LXSN稳定转染CT26.WT细胞，得到致死的亚克隆CT26.CL25。即使CT26.CL25细胞表达了典型的TAA-β-半乳糖苷酶，在正常小鼠中CT26.CL25细胞和CT26.WT细胞的生长率与致死率也保持基本一致。CT26.WT细胞与CT26.CL25细胞一起可用作测试免疫治疗程序的模型，并用于研究宿主免疫反应。 |
| 年龄（性别） | 不详 |
| 组织来源 | 器官：结肠；品系：BALB/c；疾病：癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肠癌细胞 |
| 生物安全等级 | BSL-1 |
| 致瘤性 | Yes, in BALB/c mice. Mice inoculated, subcutaneously, developed lethal tumors at 80% frequency with 1×10^3 cells and at 100% with 1×10^4 cells. Pulmonary metastases developed when mice were inoculated, intravenously, with 1×10^4 cells. |
| 抗原表达情况 | H-2d |
| 保藏机构 | ATCC; CRL-2638 BCRC; 60447 |
STR鉴定
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STR位点信息
18-3 19 6-7 12 5-5 14 X-1 25,26 1-2 17,18 7-1 25.2 8-1 13 1-1 14,15 19-2 13 15-3 21.3,22.3 12-1 16,17 6-4 18,20 4-2 21.3 3-2 14 2-1 16,17 13-1 16.2,17.2,18.2
11-2 17 17-2 15,16,17 -
STR鉴定图
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参考文献
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Enhancing tumor-specific recognition of programmable synthetic bacterial consortium for precision therapy of colorectal cancer (2024-01-20)
期刊：npj Biofilms and Microbiomes
DOI：10.1038/s41522-024-00479-8
影响因子 ：9.2
引用产品： CT26.WT 细胞 , RKO 细胞 , SW480 [SW-480] 细胞
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The Impact of Atmospheric Cadmium Exposure on Colon Cancer and the Invasiveness of Intestinal Stents in the Cancerous Colon (2024-03-14)
期刊：Toxics
影响因子 ：4.6
引用产品： CT26.WT 细胞 , CT26.WT细胞专用培养基
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Metal-enriched HSP90 nanoinhibitor overcomes heat resistance in hyperthermic intraperitoneal chemotherapy used for peritoneal metastases (2023-06-14)
期刊：Molecular Cancer
DOI：10.1186/s12943-023-01790-2
影响因子 ：37.3
引用产品： MGC80-3 [MGC-803] 细胞 , HGC-27 细胞 , CT26.WT 细胞 , CT26.WT 细胞
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Generation of whole tumor cell vaccine for on-demand manipulation of immune responses against cancer under near-infrared laser irradiation (2023-07-26)
期刊：Nature Communications
DOI：10.1038/s41467-023-40207-y
影响因子 ：16.6
引用产品： 4T1 细胞 , CT26.WT 细胞 , LLC [LL/2; LLC1] 细胞
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Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy (2023-05-24)
期刊：Advanced Science
影响因子 ：15.1
引用产品： 4T1 细胞 , CT26.WT 细胞
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Microbubbles-assisted ultrasonication to promote tumor accumulation of therapeutics and modulation of tumor microenvironment for enhanced cancer treatments (2023-06-01)
期刊：BIOMATERIALS
DOI：10.1016/j.biomaterials.2023.122181
影响因子 ：14.0
引用产品： CT26.WT 细胞 , 人脐静脉内皮细胞 , RPMI-1640 培养基
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Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment (2023-02-09)
期刊：Biomaterials Research
DOI：10.1186/s40824-023-00350-5
影响因子 ：11.3
引用产品： RAW 264.7 细胞 , CT26.WT 细胞
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Original research: Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer (2023-08-18)
期刊：Journal for ImmunoTherapy of Cancer
影响因子 ：10.9
引用产品： CT26.WT 细胞
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner (2023-02-03)
期刊：Cancer Immunology Research
DOI：10.1158/2326-6066.CIR-22-0439
影响因子 ：10.1
引用产品： Jurkat, Clone E6-1 细胞 , RKO 细胞 , CT26.WT 细胞 , B16-F10 细胞 , MC38 细胞 , 4T1 细胞 , LLC [LL/2; LLC1] 细胞 , Hepa 1-6 细胞 , YAC-1 细胞 , 293T [HEK-293T] 细胞 , AAV-293 细胞 , STR鉴定
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Aggregation-induced emission photosensitizer/bacteria biohybrids enhance Cerenkov radiation-induced photodynamic therapy by activating anti-tumor immunity for synergistic tumor treatment (2023-06-15)
期刊：Acta Biomaterialia
DOI：10.1016/j.actbio.2023.06.009
影响因子 ：9.7
引用产品： CT26.WT 细胞
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Smart Nanosystem-Mediated Inhibition of Mitochondrial Respiration for Enhanced Phototherapy-Induced Antitumor Immunity (2023-06-25)
期刊：International Journal of Nanomedicine
影响因子 ：8.0
引用产品： CT26.WT 细胞 , RPMI-1640 培养基 , 特级胎牛血清
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Dual-inhibition of lactate metabolism and Prussian blue-mediated radical generation for enhanced chemodynamic therapy and antimetastatic effect (2023-04-18)
期刊：Nanoscale
影响因子 ：6.7
引用产品： RPMI-1640完全培养基 (含10%FBS） , NCTC clone 929 [L 细胞, L-929] 细胞 , CT26.WT 细胞
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Tumor-targeting engineered probiotic Escherichia coli Nissle 1917 inhibits colorectal tumorigenesis and modulates gut microbiota homeostasis in mice (2023-04-24)
期刊：LIFE SCIENCES
影响因子 ：6.1
引用产品： CT26.WT 细胞
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Ansofaxine hydrochloride inhibits tumor growth and enhances Anti-TNFR2 in murine colon cancer model (2023-12-14)
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2023.1286061
影响因子 ：5.6
引用产品： CT26.WT 细胞 , MCA38 细胞 , 4T1 细胞 , 特级胎牛血清
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Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment (2023-03-02)
期刊：Frontiers in Microbiology
DOI：10.3389/fmicb.2023.1111911
影响因子 ：5.2
引用产品： CT26.WT 细胞
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Ferulic Acid Induces Autophagy and Apoptosis in Colon Cancer CT26 Cells via the MAPK Pathway (2023-08-11)
期刊：MOLECULES
影响因子 ：4.6
引用产品： CT26.WT 细胞
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Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway (2023-12-27)
期刊：Pharmaceuticals
影响因子 ：4.6
引用产品： HCT 116 细胞 , SW480 [SW-480] 细胞 , CT26.WT 细胞
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Self-Assembled Amphiphilic Camptothecin Nanoparticles with Glutathione-Responsive and Tumor-Targeting Ability for Enhanced Colorectal Cancer Therapy (2023-09-21)
期刊：Advanced Therapeutics
影响因子 ：4.6
引用产品： CT26.WT 细胞
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Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression (2023-03-22)
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113565
影响因子 ：3.7
引用产品： CT26.WT 细胞
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MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+tumor-infiltrating lymphocytes of colorectal cancer (2023-11-30)
期刊：CELLULAR AND MOLECULAR BIOLOGY
DOI：10.14715/cmb/2023.69.12.37
影响因子 ：1.6
引用产品： CT26.WT 细胞
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Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments (2022-11-09)
期刊：Science Advances
影响因子 ：15.0
引用产品： Hela 细胞 , HT-29 细胞 , HCT 116 细胞 , CT26.WT 细胞 , DMEM高糖 培养基 , McCoy's 5A 培养基 , RPMI-1640 培养基
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A hybrid of lactic acid bacteria and metal-organic frameworks potentiates photodynamic immunotherapy for hypoxia-targeted tumor eradication (2022-08-12)
期刊：Science China-Materials
影响因子 ：8.6
引用产品： CT26.WT 细胞 , RAW 264.7 细胞
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CAR-T-Cell Therapy for Solid Tumors Positive for Fibronectin Extra Domain B (2022-09-14)
期刊：Cells
影响因子 ：7.7
引用产品： U-87 MG 细胞 , A549 [A-549] 细胞 , F9 细胞 , CT26.WT 细胞
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Arrangement of Indocyanine Green in a 1.5-Nanometer Channel to Achieve High-Efficiency Imaging of the Intestinal Lymphatic System (2022-12-08)
期刊：MOLECULES
影响因子 ：4.9
引用产品： 小鼠淋巴管内皮细胞 , RAW 264.7 细胞 , CT26.WT 细胞
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A serum metabolomics study based on LC-MS: Chemosensitization effects of Rauvolfia vomitoria Afzel. combined with 5- fluorouracil on colorectal cancer mice (2022-09-22)
期刊：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
DOI：10.1016/j.jpba.2022.115074
影响因子 ：3.6
引用产品： CT26.WT 细胞
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Disulfiram-loaded hollow copper sulfide nanoparticles show anti-tumor effects in preclinical models of colorectal cancer (2022-10-07)
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2022.10.027
影响因子 ：3.3
引用产品： CT26.WT 细胞
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Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation (2002-01-20)
期刊：Drug Design Development and Therapy
影响因子 ：4.3
引用产品： CT26.WT 细胞
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Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer (2001-00-20)
期刊：Aging-US
影响因子 ：5.2
引用产品： HCT 116 细胞 , SW480 [SW-480] 细胞 , RKO 细胞 , CT26.WT 细胞
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Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway (2004-00-20)
期刊：Frontiers in Microbiology
影响因子 ：5.2
引用产品： CT26.WT 细胞
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Bifunctional liposomes reduce the chemotherapy resistance of doxorubicin induced by reactive oxygen species (2008-09-20)
期刊：Biomaterials Science
影响因子 ：6.6
引用产品： CT26.WT 细胞
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A tungsten nitride-based degradable nanoplatform for dual-modal image-guided combinatorial chemo-photothermal therapy of tumors (2012-08-20)
期刊：Nanoscale
影响因子 ：6.7
引用产品： CT26.WT 细胞 , 4T1 细胞
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